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Objective: To determine the frequency, characteristics, and outcomes of cerebrovascular events (CerVEs), as well as clinical and autoantibody associations in a multiethnic/racial inception cohort of patients with systemic lupus erythematosus (SLE). Methods: A total of 1,826 patients were assessed annually for 19 neuropsychiatric (NP) events, including 5 types of CerVEs: 1) stroke, 2) transient isc
Most sectors of modern society are currently undergoing rapid digitalization. With the progress of this development IT networks are becoming an ever more crucial asset whose failure are prone to cause economic losses and risks to health and safety of the population. Due to this development, it is increasingly important that IT networks are designed to be resilient, meaning that they either maintai
BACKGROUND: Iron deficiency is the most common micronutrient deficiency worldwide, negatively affecting quality of life and health. Young women are at particularly high risk due to increased iron demands during growth, menstrual blood losses, and dietary habits. There are no official guidelines recommending screening for iron deficiency in healthy young women. This study aimed to develop a screeni
Measuring the number concentration of colloidal nanoparticles (NPs) is critical for assessing reproducibility, enabling compliance with regulation, and performing risk assessments of NP-enabled products. For nanomedicines, their number concentration directly relates to their dose. However, the lack of relevant reference materials and established traceable measurement approaches make the validation
Robots used in manufacturing today are tailored to their tasks by system integration based on expert knowledge concerning both production and machine control. For upcoming new generations of even more flexible robot solutions, in applications such as dexterous assembly, the robot setup and programming gets even more challenging. Reuse of solutions in terms of parameters, controls, process tuning,
BACKGROUND: Immunohistochemical staining for tumor-associated proteins is widely used for the identification of novel prognostic markers. Recently, a tissue-conserving, high-throughput technique, tissue microarray, has been introduced. This technique uses 0.6-mm tissue core biopsy specimens, 500 to 1000 of which are brought into a new paraffin array block, which can be sectioned up to 100 times. M
Background: The 39 item Parkinson's disease questionnaire (PDQ-39) is the most widely used patient reported rating scale in Parkinson's disease. However, several fundamental measurement assumptions necessary for confident use and interpretation of the eight PDQ-39 scales have not been fully addressed. Methods: Postal survey PDQ-39 data from 202 people with Parkinson's disease (54% men; mean age 70
Genetic factors appear to contribute to the severity and progression of diabetic retinopathy. We assessed the associations of the C807T and Glu505Lys variants of the glycoprotein Ia (alpha(2) integrin) subunit of the platelet/endothelial collagen receptor and risk of retinopathy in a population-based survey of 288 diabetic patients in one Swedish community. Neither variant was associated with reti
Summary This report presents results from the project ”Converting direct resistive electric heating into district heating - customer related aspects” conducted at the division of Efficient Energy Systems, Department of Energy Sciences, Lund University. The main objective of this study was to investigate how specific households within one housing area (Sandsbro in Växjö with 110 one-family houses)
Hormonal cancers such as breast and prostate cancer arise from steroid hormone-regulated tissues. In addition to breast and prostate cancer hormonal regulation has also a role in endometrial, ovarian, testis and thyroid carcinomas. The effects of estrogens, androgens and progestagens on tumor growth are largely mediated by paracrine and autocrine target molecules which include growth factors and g
Kinins are proinflammatory peptides that mediate numerous vascular and pain responses to tissue injury. Two pharmacologically distinct kinin receptor subtypes have been identified and characterized for these peptides, which are named B1 and B2 and belong to the rhodopsin family of G protein-coupled receptors. The B2 receptor mediates the action of bradykinin (BK) and lysyl-bradykinin (Lys-BK), the
Popular Abstract in Swedish Syftet med denna avhandling är att utforska fenomenet vetenskapligt kritiskt tänkande, när det gäller dess olika innebörder, villkor och utveckling. Kritiskt tänkande studeras genom att analysera olika filosofiska och pedagogiska texter, utifrån ett hermeneutiskt-fenomenologiskt perspektiv. Avhandlingen som är skriven på engelska erbjuder läsaren en inblick i hur min egThe purpose of this thesis is to explore the phenomenon of critical thinking in scholarship as regards its meanings, conditions, and development using a hermeneutic-phenomenological approach. This exploration takes its departure in ancient Greece, following a historical movement of the phenomenon up to present day perspectives on critical thinking, revealing a range of different meanings and condi
Popular Abstract in Swedish Gel-dosmätningar för kontroll av strålbehandling av cancertumörer När en patient strålbehandlas avser man att bestråla sjuka områden i kroppen. Det är dock omöjligt att göra detta utan att därmed även till viss del stråla på omkringliggande organ och komplikationer kan då uppstå. För att minimera dessa bieffekter och optimera behandlingen används ofta en så kallad dospGel dosimetry was used together with magnetic resonance imaging (MRI) to measure three-dimensional absorbed dose distributions in radiation therapy. Two different dosimeters were studied: ferrous- and monomer gel, based on the principles of radiation-induced oxidation and polymerisation, respectively. Single clinical electron and photon beams were evaluated and gel dose distributions were mainly w
The purpose of the study was to evaluate patient relevant outcome after total hip replacement (THR) in patients with primary osteoarthritis (OA). 247 patients >50 years of age with primary hip OA, operated on with THR (Sept1995—Oct1998), were investigated consecutively and prospectively. 68 of the THR were made with hybrid technique. A preoperative radiographic classification was made. Evaluation
High performance requirements increased the popularity of unconventional architectures. While providing better performance, such architectures are generally harder to program and generate code for. In this paper, we present our approach to ease programmability and code generation for such architectures. We present a domain specific language (DSL) for the programming part, and a constraint programm
Robotic force control refers to the control and programmable specification of the interaction forces between a robot end effector and the work object, where either the end effector or the work object is attached to the robot manipulator. A rudimentary approach is to consider the joint torques and controlled variables, and then to compute those torques such that a presumably rigid manipulator effec
Background Evaluating the external validity of clinical trials requires knowledge not only of the study population but also of a relevant reference population. The main aim of this study was to present data from a large, contemporary, population-based cohort of patients with colonic cancer. Methods Data on patients diagnosed between 2007 and 2011 were extracted from the Swedish Colon Cancer Regist
This paper presents a flexible architecture suitable for concurrent processing of multiple radio standards. The proposed architecture is based on a coarse-grained reconfigurable cell array, consisting of distinct processing and memory cells. Flexibility of the architecture is demonstrated by performing a coarse time synchronization and fractional frequency offset estimation for multiple OFDM stand
CONTEXT: High-quality fatigue rating scales are needed to advance the understanding of fatigue and determine the efficacy of interventions. Several fatigue scales are used in Parkinson's disease, but few have been tested using modern psychometric methodology (Rasch analysis). OBJECTIVES: To examine the measurement properties of the generic Functional Assessment of Chronic Illness Therapy-Fatigue (
In the Bas-Draa Inlier (Anti-Atlas, Morocco), the Paleoproterozoic basement which is cut by the Ediacaran Taourgha granite is also crosscut by numerous dykes of a variety of trends, mostly of uncertain age. Two doleritic dykes are dated by the ID-TIMS U-Pb method on baddeleyite and yield emplacement ages of 1381 +/- 8 Ma (MSWD = 0.84) and 1384 +/- 6 Ma (MSWD = 1.4) determined for a N135 degrees E
