Filtyp
The rare but clinically important null phenotypes of the P1PK and GLOB blood group systems are due to alterations in A4GALT and B3GALNT1, respectively. A recently identified single-nucleotide polymorphism in Exon 2a of A4GALT predicts the common P1 and P2 phenotypes but rare variants have not been tested.
Dyskinesia and motor fluctuations affect up to 90% of patients with Parkinson's disease (PD) within ten years of L-DOPA pharmacotherapy, and represent a major challenge to a successful clinical management of this disorder. There are currently two main treatment options for these complications, namely, deep brain electrical stimulation or continuous infusion of dopaminergic agents. The latter is ac
Manual corpus annotation facilitates exhaustive and detailed corpus-based analyses of evaluation that would not be possible with purely automatic techniques. However, manual annotation is a complex and subjective process. Most studies adopting this approach have paid insufficient attention to the methodological challenges involved in manually annotating evaluation - especially concerning transpare
Although effective therapies for haemophilia have been available for decades, the prevention and treatment of joint disease remain major clinical concerns for all haemophilia patients. Early identification of joint disease is vital to initiate or modify treatment, and prevent arthropathy. However, there remains a need for more sensitive and accurate methods, which may also detect improvement in pa
Maternal diet during pregnancy has been proposed to increase the risk of autoimmune diseases.
The Fifth Assessment Report (AR5) of the Intergovernmental Panel on Climate Change (IPCC) in 2013–2014 was the most comprehensive analysis of anthropogenic climate change, its impacts, and potential responses. It concluded that climate change is “unequivocal” and human activities are the dominant cause. Avoidance of “dangerous” climate change will require sustained substantial reductions of emissi
Objective The theory behind the Job Content Questionnaire (JCQ) presumes that the "objective" social environment is measurable via self-report inventories such as the JCQ. Hence, it is expected that workers in identical work will respond highly similar. However, since no studies have evaluated this basic assumption, we decided to investigate whether workers performing highly similar work also resp
To investigate the role of P2Y1 and P2Y12 receptors in hypoxia- and adenosine diphosphate (ADP)-induced pulmonary vasoconstriction.
By examining the reception of Edme Boursault’s first fable comedy, Ésope (1690), the paper discusses the historical prerequisites of an interlacing of fable and comedy. The several 18th century translations of Boursault’s drama often have been taken as a pretext for the success of his genre experiment. The fusion of fable and comedy was, however, not in all respects in line with literary horizons
Swedish Red (SR) dairy cattle is the second most common breed in Sweden and hence SR milk quality is crucial for the nutritional value and the processability of the milk delivered to the Swedish dairies. This thesis will give an insight into the quality of milk from SR cows and it will illuminate the possibilities for improvements of both breeding programs and the quality of different dairy produc
Popular Abstract in Swedish Allteftersom kraven på kvalité och prestanda hos dagens produkter ökar används alltmer avancerade material som en del av modern produktion. Problemet som uppstår är dock att dessa material ställer nya krav på tillverkningsprocessen och då inte minst vid skärande bearbetning. Trots att en betydande mängd forskning redan har publicerats vad gäller skärande bearbetning av As quality and performance demands on today’s products increases, more and more advanced materials are being used during modern production. The problem is however that this in turn place new demands on the machining processes utilized. Even though a significant amount of research has been published on the machining of these materials knowledge is still limited in several crucial areas. A problem w
Desalination can be a cost-effective way to produce fresh water and possibly electricity. The Gaza Strip has had a complex hydro-political situation for many years. Gaza is bordered by the Mediterranean in the west, by Israel in the north and east and by Egypt in the south. Water and electricity consumption in the Gaza Strip is expected to increase in the future due to the increasing population.
Popular Abstract in Swedish Transplantation av nervvävnad till hjärnan är inte en ny idé. Redan 1890, publiserade Thompson de första försöken att transplantera vuxen hjärnvävnad till det vuxna centrala nervsystemet och han rapporterade att vävnaden överlevde i sju veckor "without wholly losing its identity". Trots detta var det först under 1970-talet som metoderna för intracerebral nervcellstranspIntracerebral neuronal transplantation have been shown to ameliorate symptoms of brain dysfunction in both animals models and Parkinson's disease, although problems still remain. The newly introduced technique of ex vivo gene transfer could serve as an alternative approach, possible avoiding some of the draw-backs of the embryonal tissue used in neuronal grafting. We have investigated the feasibli
