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The interaction between mycobacteria and epithelium is unexplored, but may determine the outcome of the infection. We have analyzed the role of two G protein-coupled receptors, CXCR1 and CXCR2 that are important regulators of many pulmonary diseases. We found that mycobacteria significantly increased the expression of both CXCR1 and CXCR2 on alveolar epithelial cells and both receptors were found

In the past, ABO incompatibility was considered an absolute contraindication to heart transplantation (HT) in adults. Advances in ABO-incompatible HT in pediatric patients and ABO-incompatible abdominal transplantation in adult patients have led to clinical exploration of intentional ABO-incompatible HT in adults. However, it is not well known how outcomes in ABO-incompatible adult heart transplan

Qualitative description of spray structure and geometry in the near-field region of atomizing sprays is particularly challenging due to the lack of visibility through such optically dense media. Similarly, quantitative determination of the optical depth can be particularly underestimated as a result of detecting photons which have experienced a number of scattering events. In this paper we demonst

Under konferensen TED-Global 2009 uppträdde författarinnan Chimamanda Adichie med The Danger of a single story som vill varna för det ensidiga berättandets stigmatiserande konsekvenser. Då talet är uppbyggt av berättelser förenas det litterära och det retoriska. Med analysmetoden Narrative Criticism ville jag undersöka hur några narrativa strategier rörande berättelsens karaktärer, dess sceniska p

With this essay I have examined the view of the saints during different epochs of the Middle Ages and what they considered distinguised a saint. The sources I have used in my examination are three different hagiographies: Dialogi de vita et miraculis patrum Italicorum part 2 by Pope Gregory the Great in the 6th century, Vita Ansgarii by Rimbert in the 9th century and Vita Anselmi archiepiscopi Can

Background:Aseptic loosening remains a main complication following total knee arthroplasty (TKA), requiring revision surgery. Radiostereometric analysis (RSA) can assess the risk of aseptic loosening. This study evaluated the migration and segmental motion of cemented and uncemented femoral and asymmetrical tibial Persona components (Zimmer Biomet) with model-based RSA.Methods:We conducted a rando

BACKGROUND: Recent research using a data-driven cluster approach has identified five discordant subclassifying body mass index (BMI) subgroups, characterized by cardiometabolic biomarkers deviated from those predicted by BMI.OBJECTIVE: This study aimed to investigate the associations of these subgroups with risks of metabolic dysfunction-associated steatotic liver disease (MASLD) and liver-related

Proposals that gesture played a pivotal role in the evolution of language have been highly influential. However, there are many differences between gestural origin theories, including different definitions of 'gesture' itself. We use a cognitive semiotic approach in order to categorize and review these theories. A semiotic system is a combination of signs or signals of particular type, defined by

Digitalization poses significant challenges to the EU VAT system, as it does in other areas of law. These challenges can be broadly divided into two main categories: those stemming from transformations in the economy, and those related to the legislative responses to these changes. In the VAT context, the first category includes the growing volume of transactions—particularly cross-border transact

In this chapter, I describe how technological progress triggers and shapes structural change within the economy and society, which in turn—if the resulting changes are significant enough—may shift the scope and outcome of established legislation and regulatory frameworks. The argument presented focuses on the ongoing digitalization, using its common technological characteristics to identify and de

The lung may be the organ whose mechanical environment needs to be most finely tuned to achieve optimal function. These needs have to be fulfilled at multiple scales, from proper force transmission between the chest wall and the parenchyma to reduction of surface tension by surfactants inside the alveoli. In addition, a plethora of mechanical loads and forces takes place within the lung, from the

Background: Sedation is often provided to resuscitated out-of-hospital cardiac arrest (OHCA) patients to tolerate post-cardiac arrest care, including temperature management. However, the evidence of benefit or harm from routinely administered deep sedation after cardiac arrest is limited. The aim of this trial is to investigate the effects of continuous deep sedation compared to minimal sedation o

Contributing to global urban history, planning theory and the geography of ideas, this article discusses the travels of Henri Lefebvre’s The Right to the City in the wake of May 1968, in France. That year, under the direction of Mario González and Max Baquero, a small team including the Italian architect Vittorio Garatti, French planner Jean-Pierre Garnier and Spanish architect Eusebio Azcue, at t

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesis is shaped not only by viral entry mechanisms but also by interactions with host and microbial factors. The viral spike (S) protein can bind Gram-negative bacterial lipopolysaccharide (LPS), a driver of hyperinflammation in severe COVID-19. How viral evolution over the years alters this interaction remains unclear. Here, we i

Accessible design enables participation in the digital society for everyone. However, cognitive accessibility is not well established within the field of web design. The International Classification of Functioning, Disability and Health (ICF) provides a descriptive framework that relates health conditions to functioning and participation. ICF Core Sets are purposefully tailored shortlists of ICF c

Gut-associated lymphoid tissues (GALT) represent major sites of adaptive immune priming in the intestine, yet our understanding of human GALT diversity and function remains limited. Here, we used single-cell RNA sequencing, flow cytometry, and confocal laser microscopy to map the fibroblast (FB) landscape of human GALT, including that of Peyer's patches (PP), mucosal isolated lymphoid follicles (M

The (African) COP27: From Blame Game to Building Bridges - The Raoul Wallenberg Institute of Human Rights and Humanitarian Law Skip to content Search for: Search Button Home About Us Who We Are Our History About Raoul Wallenberg Our Theory of Change Staff Opportunities Annual Reports Whistleblower Our work What we do Multi-Disciplinary Research Higher Education Strategic Advice and Analysis Outrea

https://rwi.lu.se/blog/the-african-cop27-from-blame-game-to-building-bridges/ - 2026-05-31