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Recent comparative observations of long-duration gamma-ray bursts (LGRBs) and core collapse supernova (cc SN) host galaxies demonstrate that these two, highly energetic transient events are distributed very differently upon their hosts. LGRBs are much more concentrated on their host galaxy light than cc SN. Here we explore the suggestion that this differing distribution reflects different progenit
Limb-girdle muscular dystrophy types 2E and F are characterized by skeletal muscle weakness and often cardiomyopathy and are due to mutations in the genes encoding beta- and delta-sarcoglycan. We previously demonstrated that loss of sarcoglycans in smooth muscle leads to constrictions of the microvasculature that contributes to the cardiac phenotype. It is unclear how vasculature abnormalities aff
Collagen induced arthritis (CIA) is a common mouse model for rheumatoid arthritis. Two sets of truncated peptides derived from type II collagen have been prepared and tested for binding to A(q), a MHC-II molecule associated with development of CIA. Binding to A(q) correlated well with predictions from a computer-based model. T-cell hybridomas, obtained in CIA, were also used to study the ability o
The dendritic cell (DC) lineage encompasses a diverse population of cells with unique subtype-specific functions. In peripheral blood, four DC subsets have been identified based on their distinct expression of CD1c, CD141, CD16, and CD123, and these subpopulations exhibit functional properties in immune responses. However, their respective roles in allergic diseases, such as rhinitis, are unclear.
To address the hotly debated question of motor system involvement in language comprehension, we recorded neuromagnetic responses elicited in the human brain by unattended action-related spoken verbs and nouns and scrutinized their timecourse and neuroanatomical substrates. We found that already very early on, from similar to 80 ms after disambiguation point when the words could be identified from
We have determined how the bulk behavior of mixtures of small cationic poly(amidoamine) dendrimers (generation 2, PAMAM-G2) and sodium dodecyl sulfate (SDS) affects the structure and composition of the adsorbed layers at the air-water interface. The aim is to reveal how the size of a well-defined hyperbranched polyelectrolyte affects the interfacial and bulk solution behavior of mixtures with oppo
The interaction between mycobacteria and epithelium is unexplored, but may determine the outcome of the infection. We have analyzed the role of two G protein-coupled receptors, CXCR1 and CXCR2 that are important regulators of many pulmonary diseases. We found that mycobacteria significantly increased the expression of both CXCR1 and CXCR2 on alveolar epithelial cells and both receptors were found
In the past, ABO incompatibility was considered an absolute contraindication to heart transplantation (HT) in adults. Advances in ABO-incompatible HT in pediatric patients and ABO-incompatible abdominal transplantation in adult patients have led to clinical exploration of intentional ABO-incompatible HT in adults. However, it is not well known how outcomes in ABO-incompatible adult heart transplan
Qualitative description of spray structure and geometry in the near-field region of atomizing sprays is particularly challenging due to the lack of visibility through such optically dense media. Similarly, quantitative determination of the optical depth can be particularly underestimated as a result of detecting photons which have experienced a number of scattering events. In this paper we demonst
Under konferensen TED-Global 2009 uppträdde författarinnan Chimamanda Adichie med The Danger of a single story som vill varna för det ensidiga berättandets stigmatiserande konsekvenser. Då talet är uppbyggt av berättelser förenas det litterära och det retoriska. Med analysmetoden Narrative Criticism ville jag undersöka hur några narrativa strategier rörande berättelsens karaktärer, dess sceniska p
With this essay I have examined the view of the saints during different epochs of the Middle Ages and what they considered distinguised a saint. The sources I have used in my examination are three different hagiographies: Dialogi de vita et miraculis patrum Italicorum part 2 by Pope Gregory the Great in the 6th century, Vita Ansgarii by Rimbert in the 9th century and Vita Anselmi archiepiscopi Can
Background:Aseptic loosening remains a main complication following total knee arthroplasty (TKA), requiring revision surgery. Radiostereometric analysis (RSA) can assess the risk of aseptic loosening. This study evaluated the migration and segmental motion of cemented and uncemented femoral and asymmetrical tibial Persona components (Zimmer Biomet) with model-based RSA.Methods:We conducted a rando
BACKGROUND: Recent research using a data-driven cluster approach has identified five discordant subclassifying body mass index (BMI) subgroups, characterized by cardiometabolic biomarkers deviated from those predicted by BMI.OBJECTIVE: This study aimed to investigate the associations of these subgroups with risks of metabolic dysfunction-associated steatotic liver disease (MASLD) and liver-related
Proposals that gesture played a pivotal role in the evolution of language have been highly influential. However, there are many differences between gestural origin theories, including different definitions of 'gesture' itself. We use a cognitive semiotic approach in order to categorize and review these theories. A semiotic system is a combination of signs or signals of particular type, defined by
Digitalization poses significant challenges to the EU VAT system, as it does in other areas of law. These challenges can be broadly divided into two main categories: those stemming from transformations in the economy, and those related to the legislative responses to these changes. In the VAT context, the first category includes the growing volume of transactions—particularly cross-border transact
In this chapter, I describe how technological progress triggers and shapes structural change within the economy and society, which in turn—if the resulting changes are significant enough—may shift the scope and outcome of established legislation and regulatory frameworks. The argument presented focuses on the ongoing digitalization, using its common technological characteristics to identify and de
