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This thesis, which is based on four original papers, covers different aspects of antibody development. The overall goal of my work has been to obtain an increased understanding of antibody repertoires as they develop in vivo and in vitro. In Paper I-III antibody repertoires was evaluated and used to dissect virus-induced antibody responses and characterize such antibodies. Furthermore, tools for m

A model for foot skin temperature prediction was evaluated on the basis of an experiment on subjects at -10.7 °C (light seated manual work) with winter boots. Insulation of the footwear was measured on a thermal foot model. The predicted temperature stayed higher for the whole exposure period and the difference between the predicted and the measured foot skin temperatures grew proportionally with

In this paper, we cast the idea of antithetic sampling, widely used in standard Monte Carlo simulation, into the framework of sequential Monte Carlo methods. We propose a version of the standard auxiliary particle filter where the particles are mutated blockwise in such a way that all particles within each block are, first, offspring of a common ancestor and, second, negatively correlated conditio

In almost all countries in the Middle East and North Africa (MENA) region, power sectors are characterized by a high degree of vertical integration and state control. However, several countries have undertaken reforms in order to open up the power market for private sector involvement particularly in relation to renewable energy (RE) sourced electricity generation. The majority of the MENA countri

We present an iterative retrieval algorithm based on data constraint for ultrashort pulse characterization using dispersion scan (d-scan). The proposed algorithm is much faster and leads to a drastic reduction of retrieval times, but, compared to the standard algorithm, it performs less robustly in the retrieval of noisy d-scan traces. The algorithm is tested on several simulated cases and in two

The article is an introduction to the festival 'Visioner av Nuet' Stockholm, 1966. The article focuses on the historical event, and contextualizes it to both the discussions on art and technology at the time, and to the planned collaborations with the prominent artists from the American group E.A.T. such as Billy Klüver, John Cage, Robert Rauchenberg and Öyvind Fahlström, - collaborations that nev

We performed high-resolution simulations of two stellar collisions relevant for stars in globular clusters. We considered one head-on collision and one off-axis collision between two 0.6-Msolar main-sequence stars. We show that a resolution of about 100000 particles is sufficient for most studies of the structure and evolution of blue stragglers. We demonstrate conclusively that collision products

A quarter of DA white dwarfs are metal polluted, yet elements heavier than helium sink down through the stellar atmosphere on time-scales of days. Hence, these white dwarfs must be the currently accreting material containing heavy elements. Here we consider whether the scattering of comets or asteroids from an outer planetary system, following stellar mass-loss on the asymptotic giant branch, can

Individuals with autism spectrum disorder (ASD) experience high levels of anxiety symptomatology with an estimated prevalence rate of anxiety disorders as high as 40 %. It is likely that anxiety is prominent in individuals with ASD throughout the life-span and that factors such as age, IQ, and ASD symptoms may influence the rates, symptoms, or anxiety subtypes. The high comorbidity rate of anxiety

This paper addresses the design of self-timed energy minimum circuits, operating in the sub-VT domain. The paper presents a generic implementation template using bundled-data circuitry and current sensing completion detection. To support this, a fully-decoupled latch controller has been developed, which integrates the current sensing circuitry. The paper outlines a corresponding design flow, which

This study presents evidence from event-related potentials for the use of both right- and left-edge boundary tones as cues for syntactic structure during online speech processing. A temporal model for the neurophysiological processing of prosodic features is outlined.

‘Transition’ was a concept used to denote that the former communist states in Europe were on the track towards establishment of a market economy in the wake of the collapsed planned economy. Another connotation of the concept was democracy – or democratisation – and a third, which was introduced when it became obvious that institutions were important for the transition to succeed, the Rechtsstaat,