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If a tree falls in a forest and no one is around to hear it, does it make a sound? - A study of the democratic obligations of DR

This thesis investigates the Danish public service station DR and the national structure of the media. As the democratic process has increasingly moved from the national level to the EU and as Danes rely on television as the main source of information on European political matters, it is only reasonable to expect the national public service station, DR, to fulfil that role, nonetheless previous st

Old Methods, New Means: Persuasive Technology in a Social Platform

Persuasive Technology, technology that is designed to change users’ attitudes or behaviors, has been exercised for a long time. Designing a technology that can change users’ attitudes or behaviors is a process that needs to be carefully thought through. Captology makes this process easier by defining the most important factors that technology needs to contain in order to be classified as Persuasiv

Optimized density gradient separation of leukocyte fractions from whole blood by adjustment of osmolarity

Some of the compounds used for density gradient separation of blood cells have high osmolarities at the concentrations needed to create the required specific densities. Several mixed media use a combination of hyperosmolar shrinkage and red cell aggregation to improve cell separation. Due to the characteristics of Percoll density gradient medium the density and osmolarity of the gradient can be co

Backcross and partial advanced intercross analysis of nonobese diabetic gene-mediated effects on collagen-induced arthritis reveals an interactive effect by two major loci.

Genetic segregation analysis between NOD and C57BL strains have been used to identify loci associated with autoimmune disease. Only two loci (Cia2 and Cia9) had earlier been found to control development of arthritis, whereas none of the previously identified diabetes loci was of significance for arthritis. We have now made a high-powered analysis of a backcross of NOD genes on to the B10.Q strain

Computational and experimental methods for deciphering the epigenetic code in hematopoietic stem cell lineage commitment

The emergence of post-genomic approaches that couple chromatin immunoprecipitation (ChIP) assays to high-throughput technique has greatly advanced our ability to investigate epigenetic features associated with normal cell development and disease. Nevertheless, these techniques exhibit some limitations. Firstly, standard protocols usually require millions of cells, thus limiting their application t

Linear dsDNA Partitions Spontaneously into the Inverse Hexagonal Lyotropic Liquid Crystalline Phases of Phospholipids.

Recently, we reported that DNA associated with inverse hexagonal (H(II)) lyotropic liquid crystal phases of the lipid 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) was actively transcribed by T7 RNA polymerase. (1) Our findings suggested that key components of the transcription process, probably the T7 RNA polymerase and the DNA, remained associated with the monolithic H(II) phase throughou

Association of a hydrophobically modified polyelectrolyte and a block copolymer followed by fluorescence techniques

By using absorption and fluorescence (steady-state and time-resolved) techniques the interaction between a poly(acrylic acid) PAA, randomly grafted with pyrene (Py) units (PAAMePy55) and a triblock copolymer of poly(ethylene oxide) and poly(propylene oxide) (EO20PO68EO20, P123) was investigated. From the fluorescence data it is shown that upon addition of P123 a decrease of the (pyrene-pyrene, Py-

Dynamic Phase Diagram of a Nonionic Surfactant Lamellar Phase

The dynamic phase diagram of triethylene glycol dodecyl ether (C12E3) in D2O was determined for 40, 50, and 60 wt % of surfactant. The shear flow effect on the nonionic lamellar phase was investigated as a function of temperature and concentration. The transition from planar lamellae (L-alpha)-to-multilamellar vesicles (MLVs) was characterized by means of rheology, rheo-small-angle neutron and lig

HMGB1 in severe soft tissue infections caused by Streptococcus pyogenes.

Extracellular High Mobility Group Box 1 (HMGB1) has been associated with acute and chronic inflammatory conditions. However, little is known about HMGB1 in necrotizing bacterial infections. We hypothesized that the local HMGB1 response is excessive in severe soft tissue infections (STIs), which are characterized by necrosis and hyperinflammation. To explore this, tissue biopsies were collected fro

Complex Formation between a Fluorescently-Labeled Polyelectrolyte and a Triblock Copolymer

The association between a randomly pyrene labeled PAA polymer (PAAMePy55) and a PEO-PPO-PEO triblock copolymer (P123) in aqueous solutions of different NaCl concentrations and pHs has been studied by means of dynamic light scattering (DLS) and steady-state fluorescence spectroscopy at 40 °C. At acidic pH values, in the low P123/PAAMePy55 molar ratio regime (i.e., at low P123 concentrations), the r

Identification of conformational epitopes for human IgG on chemotaxis inhibitory protein of Staphylococcus aureus

Background The Chemotaxis inhibitory protein of Staphylococcus aureus (CHIPS) blocks the Complement fragment C5a receptor (C5aR) and formylated peptide receptor (FPR) and is thereby a potent inhibitor of neutrophil chemotaxis and activation of inflammatory responses. The majority of the healthy human population has antibodies against CHIPS that have been shown to interfere with its function in vit

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We investigate the properties of multifractal products of the exponential of stationary diffusion processes defined by stochastic differential equations with linear drift and certain form of the diffusion coefficient corresponding to a variety of marginal distribution.

Economics of Migration

Popular Abstract in Swedish Den här avhandlingen innehåller fyra uppsatser som på ett eller annat sätt relaterar till befolkningsströmningar såsom dess ekonomiska konsekvenser och orsaker. I den första uppsatsen används en hushållsundersökning från Kina för att undersöka huruvida utbildning bidrar till att höja inkomsterna hos hushåll i jordbrukssektorn. Genom regressionsanalys uppmäts korrelatioAbstract Population movements are more substantial today than at any other point in human history. If managed effectively, migration can be beneficial for all aspects of social and economic life. This thesis contains four papers, all of which are related to the economic consequences and determinants of migration, within and across countries. The first paper employs a household survey to explore

Platelet Function During Extended Prasugrel and Clopidogrel Therapy for Patients With ACS Treated Without Revascularization The TRILOGY ACS Platelet Function Substudy

Context The relationship of platelet function testing measurements with outcomes in patients with acute coronary syndromes (ACS) initially managed medically without revascularization is unknown. Objective To characterize the differences and evaluate clinical outcomes associated with platelet reactivity among patients with ACS treated with clopidogrel or prasugrel. Design, Setting, and Patients Pat

Effects of galectins and antibodies in HIV infection; Novel Assays

The high variability of the HIV envelope glycoproteins (Env), and their heavy glycan coating, contributes to the limited host immune control. Still, broadly neutralizing antibodies (bnAbs) are found in some chronically infected HIV-infected individuals, which has spurred the research on antibody-based vaccines. An important tool in detecting and studying bnAbs, are neutralization assays. Here we d

Global effects of albedo change due to urbanization

Hur många gånger har du tagit på dig en svart tröja och sedan upptäckt hur varmt det blir när solen tittar fram? Med hjälp av den erfarenheten är det säkert tydligt att mörka material värms upp mer av solens strålar än ljusa material. Man säger att mörka material ”tar till sig”, eller absorberar, en större andel av den strålning som solen sänder ut i form av ljus. Det som inte absorberas kan istälHuman population on Earth is increasing and is projected to continue increasing for many years to come. Most of the increase will probably occur in cities and the extent of urban areas will increase with it. As cities grow larger and new cities are built, the many and diverse climatic effects of urbanization will become more evident. A specific climatic effect of urbanization which has not receive

A Strategic Decision-Making Model for Supply Chain - A Void to be Filled

Many researchers emphasize the increasing strategic importance of supply chain management, but there is still a lack of concrete guidance for managers faced with strategic decisions in supply chain. Within decision-making theories, the rational decision-making model is the most commonly used. This because of its suitable foundation, enabling a structure to the complex decision process. The rationa