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Fluorescence blinking, exciton dynamics, and energy transfer domains in single conjugated polymer chains.

In order to understand exciton migration and fluorescence intensity fluctuation mechanisms in conjugated polymer single molecules, we studied fluorescence decay dynamics at "on" and "off" fluorescence intensity levels with 20 ps time resolution using MEH-PPV [poly(2-methoxy-5-(2'-ethylhexyloxy)-1,4-phenylenevinylene] dispersed in PMMA. Two types of intensity fluctuations were distinguished for sin

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A moral Historiography without Moralism. Critical views on modern Church History Efforts for realism without moral judgments have identified morals with present law. This leads to positivistic positions, where moral questions are being answered with references to historical legal situations only, without moral implications. With the political changes 1989–1990 a change in historiography followed.

Perinatal and Family Risk Factors for Non-Hodgkin Lymphoma in Early Life: A Swedish National Cohort Study.

Background: The incidence of non-Hodgkin lymphoma (NHL) in early life has increased in recent decades, but the relevant risk factors remain largely unknown. We examined perinatal and family risk factors for NHL in childhood through young adulthood. Methods: We conducted a national cohort study of 3 571 574 individuals born in Sweden in 1973-2008 who were followed for incidence of NHL through 2009

Directed Energy Transfer in Films of CdSe Quantum Dots: Beyond the Point Dipole Approximation

Understanding of Forster resonance energy transfer (FRET) in thin films composed of quantum dots (QDs) is of fundamental and technological significance in optimal design of QD based optoelectronic devices. The separation between QDs in the densely packed films is usually smaller than the size of QDs, so that the simple point dipole approximation, widely used in the conventional approach, can no lo

Computer simulation of molecular exchange in colloidal systems

In this paper, we introduce two computer simulation models to study molecular exchange between aggregates in a colloidal dispersion. The Brownian motion of the colloidal aggregates is simulated as a random walk with a Gaussian distributed step length. In model I, the exchanging molecules are simulated as discrete particles with the exchange process characterized by desorption, molecular diffusion,

SPI-C, a PU-box binding ETS protein expressed temporarily during B-cell development and in macrophages, contains an acidic transactivation domain located to the N-terminus.

Mice deficient for SPI-group ETS transcription factors PU.1 or SPI-B fail to generate lymphocytes or do not mount normal antibody mediated immune responses, respectively. PU.1 expression is restricted to B-, T-lymphocytes and macrophages, while SPI-B is expressed in B- and T-lymphocytes. SPI-C is an ETS transcription factor closely related to PU.1 and SPI-B, and expressed temporarily during B-cell

Approximate solution of boundary integral equations for biharmonic problems in non-smooth domains

This paper deals with approximate solutions to integral equations arising in boundary value problems for the biharmonic equation in simply connected piecewise smooth domains. The approximation method considered demonstrates excellent convergence even in the case of boundary conditions discontinuous at corner points. In an application we obtain very accurate approximations for some characteristics

Quantitative disease resistance: to better understand parasite-mediated selection on major histocompatibility complex.

We outline a descriptive framework of how candidate alleles of the immune system associate with infectious diseases in natural populations of animals. Three kinds of alleles can be separated when both prevalence of infection and infection intensity are measured-qualitative disease resistance, quantitative disease resistance and susceptibility alleles. Our descriptive framework demonstrates why all

Reevaluation of the Critical Concentration for Drug Susceptibility Testing of Mycobacterium tuberculosis against Pyrazinamide Using Wild-Type MIC Distributions and pncA Gene Sequencing

Pyrazinamide (PZA) is a potent first-line agent for the treatment of tuberculosis (TB) with activity also against a significant part of drug-resistant Mycobacterium tuberculosis strains. Since PZA is active only at acid pH, testing for susceptibility to PZA is difficult and insufficiently reproducible. The recommended critical concentration for PZA susceptibility (MIC, 100 mg/liter) used in the Ba

Places to Think With, Books to Think About: Words, Experience and the Decolonization of Knowledge in the Bolivian Andes

Drawing on his anthropological field work in Bolivia in the midst of profound social and political change, the author examines the attitudes of various interlocutors toward knowledge, and in particular the important differences between “hegemonic theories of knowledge and indigenous epistemologies, between propositional and non-propositional knowledge, between knowledge of the world and knowledge

Nematic Ordering of Polymers in Confined Geometry Applied to DNA Packaging in Viral Capsids.

A density functional theory of the spatial distribution and biaxial nematic order of polymers of arbitrary length and rigidity inside a spherical cavity is proposed. The local order of different chain segments is considered as an alignment to a spatially varying director field of cylindrical symmetry. The steric interactions are taken into account in the second virial approximation. Polymer densit

Structural Characterization of Nonionic Mixed Micelles Formed by C(12)EO(6) Surfactant and P123 Triblock Copolymer.

A structural characterization of mixed micelles formed in aqueous solution by the PEO-PPO-PEO triblock copolymer P123 and the nonionic surfactant C(12)EO(6) was carried out using various techniques, including ultralow shear viscosimetry, depolarized dynamic light scattering (VH-DLS), depolarized static light scattering (VH-SLS), and small-angle X-ray scattering (SAXS). The sphere-to-rod transition

Haemophilus influenzae Uses the Surface Protein E To Acquire Human Plasminogen and To Evade Innate Immunity

Pathogenic microbes acquire the human plasma protein plasminogen to their surface. In this article, we characterize binding of this important coagulation regulator to the respiratory pathogen nontypeable Haemophilus influenzae and identify the Haemophilus surface protein E (PE) as a new plasminogen-binding protein. Plasminogen binds dose dependently to intact bacteria and to purified PE. The plasm

How should antibodies against P. falciparum merozoite antigens be measured?

Immunity against malaria develops slowly and only after repeated exposure to the parasite. Many of those that die of the disease are children under five years of age. Antibodies are an important part of immunity, but which antibodies that are protective and how these should be measured are still unclear. We discuss the pros and cons of ELISA, invasion inhibition assays/ADCI, and measurement of aff

Role of arachidonic acid metabolites in airway responses induced by trimellitic anhydride in actively sensitized guinea pigs

We studied the role of arachidonic acid metabolites, histamine, and 5-HT in airway responses to trimellitic anhydride (TMA) in actively sensitized guinea pigs. Sensitization was produced by two intradermal injections of free TMA (0.1 ml of 0.3% TMA in corn oil). After 21 to 28 days, guinea pigs were anesthetized and challenged with intratracheal instillation of 0.5% TMA conjugated to guinea pig se