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The intact SP6 χ promoter stimulated transcription 30 times more efficiently than did a control promoter consisting of a TATA motif as the only promoter element. Mutation of the SP6 χ promoter decamer in two positions reduced the transcriptional stimulation activity by over 90%. Promoters containing the SP6 χ promoter octamer or a consensus octamer in front of a TATA box were ineffective immunoglo
The purpose of this thesis is to investigate what measures Baltic coastal States may take under international law to respond to the Russian shadow fleet and to the deliberate damage to submarine cables and pipelines in the Baltic Sea. The thesis addresses three research questions concerning the available legal measures and the extent to which existing international legal frameworks are sufficient
This chapter summarizes current knowledge and diagnostic criteria for T-cell prolymphocytic leukemia (T-PLL). T-PLL is an aggressive disease characterized by a proliferation of small to medium-sized lymphocytes with a postthymic phenotype usually involving the blood, bone marrow, lymph nodes, spleen, and skin. The leukemic cells are usually positive for CD2, CD3 CD5, CD7, CD43, CD52, and CD26, but
It is apparent that climate change is progressing, increasing the frequency of heavy rainfall events. In coastal areas, halocline formation caused by increased freshwater inflow can inhibit vertical mixing, reducing oxygen concentration in the bottom layer. The Ariake Sea, an inner bay in Japan with a large tidal range, has faced serious issues such as red tides and hypoxia. Previous studies
This paper firstly proposes a simple yet efficient generalized approach to apply differential privacy to text representation (i.e., word embedding). Based on it, we propose a user-level approach to learn personalized differentially private word embedding model on user generated contents (UGC). To our best knowledge, this is the first work of learning user-level differentially private word embeddin
En diskussion rörande 2 Piers och The Glass Bubble av konstnären och landskapsarkitekten Monika Gora. Verken diskuteras i förhållande till platsbegreppet och mot en bakgrund av teoretiker och konstnärer som Miwon Kwon, Maurice Merleau-Ponty, Rosalind Krauss, Robert Smithson och Ana Mendieta.
Fouling is one the most important challenges to apply membrane technology on industrial scale in the food industry. Despite significant progress in understanding and preventing fouling and in developing appropriate membrane cleaning protocols, both fouling and cleaning remain key challenges in membrane plant operation in the food industry with a significant impact on membrane plants capital (CAPEX
In the media and communications field, research investigating the digital media engagements of very young children at home has largely been restricted to survey methods relying on parental self-reports. Recognizing that qualitative approaches can provide insights in families’ practices, values, and attitudes, we argue for the fruitfulness of an ethnographic perspective, drawing on three cases from
Introduction of exogenous genetic material into primary stem cells is essential for studying biological function and for clinical applications. Traditional delivery methods for nucleic acids, such as electroporation, have advanced the field, but have negative effects on stem cell function and viability. We introduce nanostraw-assisted transfection as an alternative method for RNA delivery to human
Vad är problemet? (What is the problem?) is about human right defenders protecting the land, territorial and environment and the situation about the ongoing criminalization in Guatemala. The purpose of this essay is to highlight and understand how the State of Guatemala is talking about the represented problem (criminalization) by studying the discourse about the implementation from presented poli
T cell recognition of the type II collagen (CII) 260-270 peptide is a bottleneck for the development of collagen-induced arthritis (CIA), an animal model of rheumatoid arthritis. We have earlier made C3H.Q mice expressing CII with glutamic acid instead of aspartic acid at position 266 (the MMC-C3H.Q mouse), similar to the rat and human CII epitope, which increases binding to MHC class II and leads
Ozonization reaction of ethene in neat film at 77 K was performed. Separation of ethene secondary ozonide from the other products of the reaction was performed by continuous pumping of the reactor. Only the products, which evaporated from the walls of the reactor at 185 K, were transferred to the gas cell. The high-resolution infrared absorption spectrum of gaseous ethene secondary ozonide (C2H4O3
Peripheral blood lymphocytes from healthy, HIV sero-negative blood donors have been in vitro immunized using penv9, a recombinant fragment of the envelope of HIV-1. This primary in vitro immunization followed by Epstein-Barr virus (EBV) transformation and somatic cell fusion subsequently gave rise to several specific anti-penv9 monoclonal antibodies (MO28, MO30 and MO43) of μ isotype. The hybridom
Surface plasmon resonance, i.e. detection of changes in refractive index on a surface, was used in a biosensor to evaluate the dissociation/association rate and affinity constants of human monoclonal IgG and IgM antibodies and Tab fragments. The results showed that an observed difference in affinity constants between intact and fragmented IgG anti-tetanus antibody was related to approximately 10-f
