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Diversity and functions of intestinal mononuclear phagocytes

The intestinal lamina propria (LP) contains a diverse array of mononuclear phagocyte (MNP) subsets, including conventional dendritic cells (cDC), monocytes and tissue-resident macrophages (mÏ †) that collectively play an essential role in mucosal homeostasis, infection and inflammation. In the current review we discuss the function of intestinal cDC and monocyte-derived MNP, highlighting how these

Broad Th2 neutralization and anti-inflammatory action of pentosan polysulfate sodium in experimental allergic rhinitis

Th2 cytokines like interleukin-4, -5, and -13 are regarded as important drivers of the immunopathology underlying allergic rhinitis (AR) and asthma. The present study explores the capacity of pentosan polysulfate sodium (PPS), a semi-synthetic heparin-like macromolecular carbohydrate, to bind Th2 cytokines and exert biological neutralization in vitro, as well as anti-inflammatory actions in vivo.

Personnel resistance in public sector reform

Observations from three case studies of public sector reforms are reported. These observations concern managerial attitudes to personnel resistance, and they reveal how management talks of resistance either as an emotional reaction or as a personality trait with certain employees. Based on these assumptions it is considered legitimate to disregard employee objections. Personnel were invited to the

Experience of furniture in homes: Creating conditions for the design with consideration to people in the third age

This licentiate thesis in industrial design concerns the challenge and opportunity to meet the demographic changes and the future senior market. The aim is to explore how various user-centered design methods can be combined, modified and practiced to create conditions for the design of totally new or improved products. Design is understood as a process to develop solutions with the starting point

Simulation of Dynamic Discontinuous Recrystallization During Hot Deformation of Pure Copper

A probabilistic cellular automaton technique is employed in the simulation of dynamic discontinuous recrystallization (DDRX) in pure copper under hot deformation conditions. Important features of the present model are calibration of grain growth kinetics against the analytical solution and also the description of a misorientation-dependent grain boundary energy, valid in the entire range of misori

Quadratic Optimization of Impedance Control

This paper presents algorithms for continuous-time quadratic optimization of impedance control. Explicit solutions to the Hamilton-Jacobi equation for optimal control of rigid-body motion are found by solving an algebraic matrix equation. System stability is investigated according to Lyapunov function theory, and it is shown that global asymptotic stability holds. The solution results in design pa