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OBJECTIVE: To examine the mortality risk of blood transfusions when donor information, postdonation treatment, and a wide selection of risk factors are taken into account. METHODS: A retrospective study was performed on 9907 patients who underwent coronary artery bypass grafting and/or aortic valve replacement. Several transfusion-related risk factors, including age of blood products, sex of don

Popular Abstract in Swedish Avhandlingen syftar till att bidra till förståelsen av hur det kan komma sig att kristendomen i början av det andra århundradet utvecklas till en icke-judisk religion. Att de judendom och kristendom idag uppfattas som två olika religioner är inte så märkligt. Dock, om man betänker att kristendomen ursprungligen var en del av det första århundradets judendom så är det egThis book attempts to answer the question of how it is possible that Christianity in the beginning of the second century C.E. had developed into a non-Jewish, Gentile religion. Since Christianity was originally one of many Jewish factions within the diversified Judaism of the period, and one that even primarily seems to have directed its attention to the people of Israel, the problem of its separa

Tumor cells often carry mutations in genes that control cell survival, and become resistant to signals that trigger cell death. Yet, some cell death pathways remain intact in tumor cells. If identified, these pathways might be exploited to selectively remove tumor cells. HAMLET (human α-lactalbumin made lethal to tumor cells) is a protein-lipid complex derived from human milk that activates cell d

Herpes simplex virus type 1 (HSV-1) expresses a receptor that binds the Fc portion of IgG. This HSV-1 Fc gamma-binding protein is, like protein A of Staphylococcus aureus, known to bind human IgG1, IgG2 and IgG4 but not IgG3 subclasses. However, IgG3 with the allotype Gm(s+)(t+), prominent in the Oriental population, reacts with protein A. This prompted us to investigate the reactivity of Oriental

We have used combined quantum mechanical and molecular mechanical free-energy perturbation methods in combination with explicit solvent simulations to study the reaction mechanism of the multicopper oxidases, in particular, the regeneration of the reduced state from the native intermediate. For 52 putative states of the trinuclear copper cluster, differing in the oxidation states of the copper ion

Galectins are defined by a conserved beta-galactoside binding site, which has been linked to many of their important functions in e.g. cell adhesion, signaling and intracellular trafficking. Weak adjacent sites may enhance or decrease affinity for natural beta-galactoside containing glycoconjugates, but little is known about the biological role of this modulation of affinity (fine specificity). We

Diffuse reflectance spectroscopy (DRS) is a rapid, non-invasive optical method widely adopted to gain diagnostic information of tissue. The most flexible approach to this method is a fiber-optic contact-probe used with a spectroscopy system. A challenge of this method is that the external pressure brought by the probe can significantly affect the tissue optical properties as well as the light coup

Abstract in UndeterminedThis paper examines vowel production in Swedish adolescents with cochlear implants. Twelve adolescents with cochlear implants and 11 adolescents with normal hearing participated. Measurements were made of the first and second formants in all the nine long Swedish vowels. The values in hertz were bark-transformed, and two measures of the size of the vowel space were obtained

Crayfish spermatophores are deposited on the body surface of the female during mating and remain there for a period of time before fertilization ensues. Post-mating changes in protein expression level in the noble crayfish Astacus astacus spermatophore were quantified. In-gel digestion and high resolution mass spectrometry were used for label-free protein quantification. One hundred twelve protein

Contemporary cognitive psychology is dominated by an individualistic and mentalistic approach to the mind. This Cartesian heritage is evident in studies of social understanding, that is, how we understand others. It is argued that this approach and metaphors like reading minds have failed, and should be replaced with a discursive approach, where public and shared socio-linguistic intenand normativ

The goal of this paper is to combine corpus methodology with experimental methods to gain insights into the nature of antonymy as a lexico-semantic relation and the degree of antonymic canonicity of word pairs in language and in memory. Two approaches to antonymy in language are contrasted, the lexical categorical model and the cognitive prototype model. The results of the investigation support th