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Organ-on-a-chip devices are predominately made of the polymer polymethylsiloxane (PDMS), exhibiting several attractive properties e.g., transparency, gas permeability, and biocompatibility. However, the attachment of cells to this polymer has proven challenging, especially for delicate primary cells e.g., small intestinal organoid-derived epithelial cells. Hence, a need to functionalize and coat t

Chromosomal translocations are key events in cancer, driving oncogenesis by disrupting and deregulating critical genes. While specific tumor-associated translocations are well studied, the frequencies and distributions of most remain unknown. Additionally, the role of chromosomal reshuffling in translocations has received little attention. This study presents data on the chromosomal involvement in

In recent years, the empirical literature on cross-national unions—marriages between migrants and members of the majority population—has experienced a shift in focus, with an increasing number of studies examining assortative mating patterns within these unions. This shift marks a significant development, indicating that the classic assimilation theory is no longer considered the sole explanation

Voice problems are common among workers in occupations with high demands on oral communication. For sustaining vocal health, it is important to find efficient ways for how to reduce strain on the voice at work, and one way to do so is optimizing the room acoustics for communication. However, to date we do not know enough about what kind of room acoustic conditions that support voice and speech mos

Frihamnen i Stockholm står inför en omfattande omvandling. Området, som under lång tid har fungerat som en central plats för hamn- och industriverksamhet, planeras att utvecklas till en ny stadsdel med bostäder, kontor och service. I denna process riskerar flera befintliga industribyggnader att rivas för att ge plats åt ny bebyggelse. Samtidigt innebär detta att viktiga delar av platsens historia,

Climate change is recognized as one of the greatest environmental threats facing the world today. To tackle this problem, a protocol was adopted in Kyoto in 1997 which establishes legally binding commitments to developed countries to bring down the emissions of six major greenhouse gases by 5.2% compared to the year 1990. Three flexibility mechanisms have been provided to developed countries to ac

Purpose – The rate of turnover of hospital managers has been high in Sweden. Hospitals are regarded to be difficult to manage, which is connected with different discourses and action logics such as politics, medicine, care and management creating complex conditions for hospital management. The purpose of this paper is to analyse hospital managers' management conditions in conjunction with hospital

The present article reports on static and dynamic light scattering (SLS and DLS) studies of aqueous solutions of the nonionic surfactant C12EO6 and the poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer EO20PO68EO20 (P123) at temperatures between 25 and 45 degrees C. In water, P123 self-assembles into spherical micelles with a hydrodynamic radius of 10 nm, and at 40

We study agents situated in partially observable environments, who do not have sufficient resources to create conformant (complete) plans. Instead, they create plans which are conditional and partial, execute or simulate them, and learn from experience to evaluate their quality. Our agents employ an incomplete symbolic deduction system based on Active Logic and Situation Calculus for reasoning abo

Popular Abstract in Swedish POPULÄRVETENSKAPLIG SAMMANFATTNING Halsbränna och sura uppstötningar är vanliga åkommor i den svenska befolkningen där upp till 20 procent av de tillfrågade uppger sig ha besvär av dessa symtom varje vecka. Både halsbränna och sura uppstötningar anses vara symtom på att magsäcksinnehåll flödar tillbaka upp genom övre magmunnen till matstrupen sk gastroesofageal reflux.This thesis investigates several aspects on gastroesophageal reflux disease (GERD) and associated complications as Barrett’s esophagus and esophageal adenocarcinoma. I. To clarify the natural course of GERD, a pH-metry verified cohort was re-evaluated after 20 years. The course of GERD may well be progressive. A statement based on the evidence that reflux induced complications as esophagitis and

Brain machine interfaces with chronically implanted microelectrode arrays for signal acquisition require algorithms for successful detection and classification of neural spikes. During the design of such algorithms, signals with a priori known characteristics need to be present. A common way to establish such signals is to model the recording environment, simulate the recordings and store ground t

Background Despite recent successes with biological agents as therapy for autoimmune inflammatory diseases such as rheumatoid arthritis ( RA), many patients fail to respond adequately to these treatments, making a continued search for new therapies extremely important. Recently, the prevailing hypothesis that reactive oxygen species (ROS) promote inflammation was challenged when polymorphisms in N

The variability in the morphology, modal number of chromosomes, TCR expression and functional reactivity of a CII-specific T-cell hybridoma at continuous subcultivation have been investigated. As the number of passages increased, besides the oval semiadherent cells (normal phenotype), fibroblast-like cells (transformed phenotype) were also observed. The two cell subpopulations differed in their ka

The role of fluid-phase regulators of complement is to inhibit excessive complement activation and maintain homeostasis in blood. By binding to and inactivating complement components on cell surfaces, they can also protect autologous cells from complement-mediated cytotoxicity and phagocytosis. In this study, we wanted to find out whether C4b-binding protein (C4bp), a fluid-phase regulator of the

Anionic DNA and cationic surfactants form charge neutral complexes that contain finite amounts of water. There is a strong electrostatic attraction between the oppositely charged species, and the finite swelling is caused by an opposing repulsive force. Adding NaCl to the complexes provides an opportunity to modulate the strength of the electrostatic attraction. The thermodynamics of the isotherma

The structures of the hydrated thallium(III) halide and pseudohalide complexes, [TlX(n)(OH2)(m)]((3-n)+), X = Cl, Br, CN, in aqueous solution have been studied by a combination of X-ray absorption fine structure spectroscopy (XAFS), large-angle X-ray scattering (LAXS), and vibrational spectroscopic (Raman and IR) techniques including far-infrared studies of aqueous solutions and some solid phases

Through several decades of research, absolute paleointensity estimates have been obtained from a wide range of rocks with varying ages, covering the last 3.45 Ga years. These paleointensity data are crucial to study the past geodynamo and the geological evolution of the Earth's deep interior. However, paleointensity data are often difficult to interpret, and on-going discussions concerning the pas