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Objective: To investigate the ability of statins to activate the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-γ) in primary human monocytes in culture. Materials and methods: Human peripheral monocytes were incubated with atorvastatin (0.1-10 μmol/1) for up to 24 hours. PPAR-γ expression was analysed by electrophoretic mobility shift assay. Pro-inflammatory cytokines wer

Classical dendritic cells (cDC) can be classified into two major subsets: Irf8-dependent cDC1 and Irf4-expressing cDC2. Although these subsets play distinct roles in intestinal immune homeostasis, their functions in T cell-driven colitis remain unknown. To assess the role of IRF4 expression in cDC2 in T cell-driven colitis, CD11c-Cre.Irf4fl/fl and Irf4fl/fl mice were backcrossed onto a Rag-1-/- ba

Colour–magnitude diagrams (CMDs) are powerful tools that might be used to infer stellar properties in globular clusters (GCs), for example, the binary fraction and their mass ratio (q) distribution. In the past few years, observations have revealed that q distributions of GC main-sequence binaries are generally flat, and a distribution characterized by a strong increase towards q ≈ 1 is not typica

Vi redogör för ett patientfall med covid-19-associerad myokardit.Patienten hade förhöjda hjärtskademarkörer, men inte avsevärt stegrade inflammationsmarkörer såsom D-dimer och interleukin-6. Tidigare fallrapporter indikerar att en myokarditbild kan uppträda vid covid-19, både genom förekomst av sars-cov-2 i myokardiet och immunologisk aktivering. I detta fall var orsaken sannolikt infektion i myok

BACKGROUND: Phaeochromocytoma is sometimes not diagnosed before surgery and may present as an adrenal incidentaloma. The aim of this study was to investigate differences in clinical presentation and perioperative outcome in patients with subclinical and symptomatic phaeochromocytoma, and in patients operated with and without preoperative α-blockade. METHODS: This was a retrospective observational

Males should invest in mate attraction, mate guarding and paternal care in relation to the marginal fitness value of each of those behaviours. Since time and energy are limited, trade-offs between these activities are expected. This study demonstrates that monogamous male European starlings (Sturnus vulgaris) decrease their paternal effort in response to increased opportunities to attract addition

Bergh considers the relationship between migration and interpersonal trust in the European Union. Interpersonal trust, Bergh avers, is an important foundation for a well-functioning society. The question is how interpersonal trust is affected by increased migration in countries with differing levels of trust. Bergh shows that migrants from low-trust countries who move to high-trust ones show highe

The power of the informal settlements– The case of Dar es SalaamMaria Isabel RasmussenHousing Development & Management – HDMLund University, Swedenmaria.rasmussen@hdm.lth.seAbstractThis paper discusses the importance of the maps in urban planning and the consequences for the cities planned within a non existence of maps context, when the power decision is derived to the dwellers. Although map

Background: Sex hormones in serum have been hypothesized to influence the risk of prostate cancer. We performed a collaborative analysis of the existing worldwide epidemiologic data to examine these associations in a uniform manner and to provide more precise estimates of risks. Methods: Data on serum concentrations of sex hormones from 18 prospective studies that included 3886 men with incident p

The use of Alcohol-based antiseptics is efficient and approved, however it has some limitations. This paper examined the possibility of using hypochlorite water as a chlorine-based antiseptic for handwashing in public buildings and healthcare facilities. The electrolysis method was used, which produces Hypochlorous acid (HOCl) from mixing drinking water with small amounts of sodium hydroxide. Hypo