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Summary Inherited deficiencies in components of the classical complement pathway are strong disease susceptibility factors for the development of systemic lupus erythematosus (SLE) and there is a hierarchy among deficiency states, the strongest association being with C1q deficiency. We investigated the relative importance of the different complement pathways regarding clearance of apoptotic cells.

Context: Both leukocyte telomere length and IGF-I are associated with the aging process. A previous in vitro study suggested that IGF-I may modulate telomerase activity in white blood cells, but little is known whether these two systems interact in vivo. Patients and Methods: Leukocyte telomere length was determined using a quantitative PCR assay in 2744 elderly men (mean age 75.5 yr, range 69-81

Context: Long-term data are missing in GH-treated acute lymphoblastic leukemia (ALL) patients. GH therapy may result in poorer outcome regarding cardiovascular (CV) and particularly cardiac effects than in patients with hypothalamic-pituitary disease. Objective: Our objective was to evaluate GH therapy on CV risk, cardiac function, physical activity, and quality of life in ALL patients treated wit

An electrochemiluminescence technique was used to develop versatile and sensitive assay strategies for determination of seroreactivities against biologically important cytomegalovirus neutralization epitopes expressed on glycoprotein B. Indirect binding assays showed wide linear assay ranges and revealed that serum samples diluted in parallel with a monoclonal antibody-based standard, simplifying

Immunization strategies against commensal bacterial pathogens have long focused on eradicating asymptomatic carriage as well as disease, resulting in changes in the colonizing microflora with unknown future consequences. Additionally, current vaccines are not easily adaptable to sequence diversity and immune evasion. Here, we present a "smart" vaccine that leverages our current understanding of di

Popular Abstract in Swedish Komplementsystemet ingår i vårt naturliga immunförsvar och bidrar till det förvärvade immunförsvaret bl. a. genom att aktiveras av specifika antikroppar. Komplementsystemets viktigaste skyddsfunktioner är att försvara oss mot bakteriella infektioner, förhindra uppkomst av autoimmuna sjukdomar genom att eliminera immunkomplex och döende celler samt att fungera som en förThe complement system is critically involved in defence against bacterial infection. C2 deficiency is, apart from mannan-binding lectin (MBL) deficiency, the most common homozygous complement deficiency among Caucasians. The classical pathway of complement activation is not functional in C2 deficiency and the condition is associated with invasive infections caused by the encapsulated bacteria Stre

The Swedish Air Navigation Services Provider (LFV ANS) are undergoing major organizational changes in order to adapt to changing demands on efficiency and technical development in air traffic control. In these change processes the foundations of the safety work can be affected and changes in the existing safety culture can be introduced. In a joint research project – Human Factors in Air Navigatio

Based on recent advances in control theory, we propose the notion of jitter margin for periodic control tasks. The jitter margin isdefined as a function of the amount of constant delay in the controlloop, and it describes how much additional time-varying delay can betolerated before the loop goes unstable. Combined with schedulingtheory, the jitter margin can be used to guarantee the stability and

A technique for extracorporeal immunoadsorption of circulating specific antibodies from the plasma of rats is described. Catheterization of rats was performed using the carotid and the jugular blood vessels. The rats were treated non-anaesthetized. Blood was pumped continuously through a hollow-fibre plasma filter at a rate of 1.5 ml/min and plasma was separated and passed through an adsorbent col

A strategy for generating potential galectin inhibitors was devised based on derivatization at the C-3′ atom in 3′-amino-N-acetyllactosamine by using structural knowledge of the galectin carbohydrate recognition site. A collection of 12 compounds was prepared by N-acylations or N-sulfonylations. Hydrophobic tagging of the O-3 atom in the N-acetylglucosamine residue with a stearic ester allowed rap

Cooperative effects between molecular wires affect conduction through the wires, and studies have yet to clarify the conditions under which these effects enhance (diminish) conduction. Using a simple but general model, we attribute this crosstalk to the duality of energetic splitting and phase interference between the wires' conduction channels. In most cases, crosstalk increases (decreases) condu