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Human PBL from vaccinated healthy blood donors, which was transplanted i.p. into mice with severe combined immunodeficiency (SCID), exhibited an Ag-dependent humoral Ir against tetanus toxoid. This Ir was dose dependent and was completely abrogated by immunizing with large amounts of Ag, suggesting a high dose tolerization of the B cells. A dose-dependent selection of specific, high affinity B clo

While the economic impact of China’s ‘Belt and Road’ Initiative (BRI) in Sri Lanka has been closely monitored in recent years, few studies have focused on the role of China’s Buddhist narratives in furthering the countries’ interests. By analyzing the Buddhist strategic narratives used in official Chinese and Sri Lankan statements, this article argues that under the BRI’s ‘people-to-people’ bonds,

Oral direct inhibitors (ODIs) of thrombin and factor Xa are now approved as anticoagulant drugs. The first two drugs to complete phase III clinical trials for thromboprophylaxis in orthopaedic surgery and treatment of patients with atrial fibrillation or venous thromboembolism were dabigatran and rivaroxaban. These small molecules are given at fixed dose with no requirement for monitoring as pharm

In The Act of Documenting (2016), Winston, Vanstone and Chi connect production studies with reception studies in docmedia. This work signals how the act of documenting, a performative practice within the media industries, is intrinsically connected with the act of watching, a performative practice within cultures of viewing. There are challenges in conducting documentary audience research, in part

The human host defense peptide LL-37 influences double-stranded RNA signaling, but this process is not well understood. Here, we investigate synergistic actions of LL-37 and synthetic double-stranded RNA (poly I:C) on toll-like receptor 3 (TLR3) expression and signaling, and examine underlying mechanisms. In bronchial epithelial BEAS-2B cells, LL-37 potentiated poly I:C-induced TLR3 mRNA and prote

Metabolic reprogramming is critical during clear cell renal cell carcinoma (ccRCC) tumorigenesis, manifested by accumulation of lipid droplets (LDs), organelles that have emerged as new hallmarks of cancer. Yet, regulation of their biogenesis is still poorly understood. Here, we demonstrate that MYC inhibition in ccRCC cells lacking the von Hippel Lindau (VHL) gene leads to increased triglyceride

The diverse gut microbiota, which is associated with mucosal health and general wellbeing, maintains gut-associated lymphoid tissues (GALT) in a chronically activated state, including sustainment of germinal centers in a context of high antigenic load. This influences the rules for B cell engagement with antigen and the potential consequences. Recent data have highlighted differences between GALT

This article argues, based on the work of Bakhtin and de Certeau, that there is no aesthetics without politics and that all academic discourse and practices are enacted through aesthetic forms with inherently political and ethical effects. The article is written in a script-form with indications on how to perform it, acting out or ‘performing’ in a direct way rather than adding to the arguments al

This chapter describes the long-term social, economic, demographic, and political development of Landskrona, a mid-sized industrial city in southern Sweden. Around 1910, the population was about 15,000 and the demographic structure of the city was in line with other emerging industrial cities in Sweden. Industrial activity expanded, with some shorter periods of crisis, until the late 1960s. In mos

This chapter analyzes the long-term development of income inequality and social mobility. During the twentieth century Landskrona experienced a dramatic socioeconomic transformation that shaped economic inequality and social mobility. There were three main phases in the development of socioeconomic disparities, which reflect development at the national level. The first phase (1905–1930) saw high a