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Signaling mechanisms in L-DOPA-induced dyskinesia
Neutron stars in the galactic center
The Galactic Center is one of the most dense stellar environments in the Galaxy and is considered to be a plausible place to harbor many neutron stars. In this brief review, we summarize observational efforts in search of neutron stars within a few degrees about the Galactic Center. Up to 10% of Galactic neutron stars may reside in this central region and it is possible that more than a thousand n
T-cell cytotoxicity assays for studying the functional interaction between the superantigen staphylococcal enterotoxin A and T-cell receptors.
Cross-Linguistic Influence in Early Word Learning
It has often been the presumption that reverse cross-linguistic influence requires an advanced fluency in the second language. This assumption has led to much of the research focusing on the impact of the speaker’s existing languages towards their second or third language. Our mental lexicons are, however, in a constant state of change through learning, forgetting, and consolidation, and we should
A novel fungal pathogen under the spotlight--Acremonium spp. associated fungaemia in an immunocompetent host.
Joint effects of genes, body constitution, and lifestyle: exploring novel pathways to predict prognosis and response to therapy in breast cancer
Breast cancer is the most common cancer among women in the Western world. In Sweden, 1 in 9 women will be diagnosed during their lifetime, amounting to >8,000 new breast cancers per year. Each year around 1,400 patients die from their disease. A comprehensive report entitled "highlighted several areas in need of more research", including how weight, alcohol consumption, smoking, host metabolism an
The Extracellular Matrix : Reloaded Revolutions
Dendritic Cells in Bone Marrow at Diagnosis and after Chemotherapy in Adult Patients with Acute Myeloid Leukaemia
Dendritic cells (DCs) develop in the bone marrow from haematopoietic progenitor cells. Two subsets, plasmacytoid DCs (pDCs) and myeloid DCs (mDCs), have been identified. Little is known regarding DC levels in bone marrow of patients with acute myeloid leukaemia (AML) before and after chemotherapy. We investigated relative pDC and mDC levels in bone marrow from 37 hospital controls and 60 patients
Alpha1-microglobulin is found both in blood and in most tissues
In this study we demonstrate that, in addition to blood, alpha1-microglobulin (alpha1m) is present in most tissues, including liver, heart, eye, kidney, lung, pancreas, and skeletal muscle. Western blotting of perfused and homogenized rat tissue supernatants revealed alpha1m in its free, monomeric form and in high molecular weight forms, corresponding to the complexes fibronectin-alpha1m and alpha
Control of water activity in organic medium
Lipase-catalyzed transesterification of phosphatidylcholine at controlled water activity
The incorporation of a free fatty acid into the sn-1 position of phosphatidylcholine by lipase-catalyzed transesterification was investigated. The thermodynamic water activity of both the enzyme preparation and the substrate solution was adjusted to the same value prior to the reaction. The reaction rate increased with increasing water activity but the yield of modified phosphatidylcholine decreas
Excretion Rate and Distribution Volumes in Common Marmoset Monkeys After Slow and Fast Injection of Gadobutrol
Common marmoset monkeys (Callithrix jacchus) are increasingly used in models of neurodegenerative diseases. Serial measurements of gadolinium excretion were performed using the dual flip angle method to map R1 on three animals in the wrist coil of a 3T whole-body system. R1 values were analyzed in a ROI in the straight sinus and fitted with a single compartment model. Slow injection of 0.3 mmol Ga
Evaluation of polyurethane samplers as a tool for occupational PAH measurements.
Chelation-controlled regioselective endo cleavage and stereoselective C-1 alkylation of pentofuranosides
Combinations of Lewis acids and nucleophilic reagents trigger endo-opening of the furanoside ring of methyl furanosides 1, 10 and 13, resulting in the attachment of the nucleophilic group at C-1 of the carbohydrate. The stereoselectivity in the C-C bond-forming step is low for the 2-deoxyfuranosides but very high (dr 1:99) for the furanosides carrying a methoxy group in the 2-position when a combi
(When) Is it Worth Investing in the Personal Service Encounter?
Thoughts on the end of life in patients with oxygen-dependent chronic obstructive pulmonary disease : A qualitative interview study
Aim: The aim of the study was to deepen the current knowledge of how patients with chronic obstructive pulmonary disease and long-term oxygen treatment think about and expect end-of-life. Design: A qualitative design was used. Methods: A purposeful sample of 19 patients with oxygen-dependent chronic obstructive pulmonary disease was obtained from the Swedish National Registry on Respiratory Failur
“Brown Babies” in post-WWII Denmark : A Case Study of the Vulnerabilities of Adopted Children Born of War
Children born to occupying soldiers during or after conflicts are in many ways an extraordinarily vulnerable population. These so-called children born of war (CBOW) commonly inherit the stigma of transgression and foreignness from their respective parents and face discrimination in post-conflict societies. Their specific vulnerabilities, though, emerge from multiple overlapping factors: the needs
Human peripheral blood lymphocytes transplanted into SCID mice constitute an in vivo culture system exhibiting several parameters found in a normal humoral immune response and are a source of immunocytes for the production of human monoclonal antibodies.
Human PBL from vaccinated healthy blood donors, which was transplanted i.p. into mice with severe combined immunodeficiency (SCID), exhibited an Ag-dependent humoral Ir against tetanus toxoid. This Ir was dose dependent and was completely abrogated by immunizing with large amounts of Ag, suggesting a high dose tolerization of the B cells. A dose-dependent selection of specific, high affinity B clo
China’s Buddhist strategic narratives in Sri Lanka—benefits and Buddhism?
While the economic impact of China’s ‘Belt and Road’ Initiative (BRI) in Sri Lanka has been closely monitored in recent years, few studies have focused on the role of China’s Buddhist narratives in furthering the countries’ interests. By analyzing the Buddhist strategic narratives used in official Chinese and Sri Lankan statements, this article argues that under the BRI’s ‘people-to-people’ bonds,
