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According to Ruth Chang the three standard positive value relations: “better than”, “worse than” and “equally good” do not fully exhaust the conceptual space for positive value relations. According to her, there is room for a fourth positive value relation, which she calls “parity”. Her argument for parity comes in three parts. First, she argues that there are items that are not related by the sta

20th century massification of higher education and research in academia is said to have produced structurally stratified higher education systems in many countries. Most manifestly, the research mission of universities appears to be divisive. Authors have claimed that the Swedish system, while formally unified, has developed into a binary state, and statistics seem to support this conclusion. This

This paper provides an analysis of 67 corrody contracts from 1476-1538. By purchasing such a contract, the elderly acquired lifelong lodging and care in an institution - in this case the hospital of Sint-Pieter in Amsterdam. Most customers paid in kind, by handing over real estate and financial instruments to the hospital, or promising to do manual labour. Customers spent the equivalent of 250-400

In the second half of the fifteenth century the largest towns in the county of Holland created substantial public debts. This article puts forward the hypothesis that towns speculated on sovereign monetary policy in the process. They exposed themselves and their creditors to fluctuations in the exchange rates between silver and gold coins, which initially caused the reduction of their real 'intere

Purpose: The task-based assessment of image quality using model observers is increasingly used for the assessment of different imaging modalities. However, the performance computation of model observers needs standardization as well as a well-established trust in its implementation methodology and uncertainty estimation. The purpose of this work was to determine the degree of equivalence of the ch

Argues that there is no reason to dismiss species recognition as a possible cause of evolutionary change in moth sex pheromones. Selection for species recognition cannot explain all of the diversity in sex pheromones and the data supporting this contention are weak, but the alternative causes suggested, invoking mate choice between conspecifics as the mechanism of sexual selection, has no empirica

Only for three of the known defects in the metabolism of the amino acidsGABA, glycine, serine, and proline has a more-or-less efficient treatment been reported: the GABA catabolic defect, succinic semialdehyde dehydrogenase deficiency (vigabatrin, causing substrate depletion by inhibition of GABA transaminase); the glycine catabolic defect, nonketotic hyperglycinemia (diet combined with benzoate a

This paper describes an approach for designing lightweight components produced through additive manufacturing (AM). Lightweight design is often done through topology optimization (TO). However, the process of manually interpreting mesh-based and imprecise results from a TO into a geometry that fulfils all requirements is complex. To aid in this process, this paper suggest an approach based on comb

We characterize the Gaia–Enceladus–Sausage kinematic structure recently discovered in the Galactic halo using photometric metallicities from the SkyMapper survey, and kinematics from Gaia radial velocities measurements. By examining the metallicity distribution functions (MDFs) of stars binned in kinematic/action spaces, we find that the JR‾‾‾√ versus Lz space allows for the cleanest selection of

To study the biochemistry of processing of a soluble protein Ag by an APC, we investigated how 125 I-labeled human insulin (HI) is processed in situ by TA3 mouse hybridoma B cells. Fractionation of TA3 cells into their extracellular, plasma membrane-associated and intracellular compartments coupled with the use of HPLC enabled us to analyze several peptides derived from each compartment. One HI

An Escherichia coli strain transfected with a plasmid containing four linked human proinsulin genes was grown in the presence of 35S and 3H labelled amino acids to gain access to human insulin that was radiolabelled at 19 evenly distributed sites throughout the amino acid sequence. The multi-proinsulin precursor was cleaved at methionine residues with cyanogen bromide, then the individual proinsul

This paper presents a biocatalysis based approach for asymmetric hydrolysis of Clopidogrel, one of the most effective antiplatelet aggregators. Instead of the conventional "wet lab" screening method, we used an advanced chemical information retrieval tool, Scifinder®, to find suitable enzyme candidate(s) for the asymmetric hydrolysis. Scifinder® search for reactions similar to the target reaction