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The XXL survey currently covers two 25deg2 patches with XMM observations of ∼10ks. We summarize the scientific results associated with the first release of the XXL dataset, which occurred in mid-2016. We review several arguments for increasing the survey depth to 40ks during the next decade of XMM operations. X-ray (z<2) cluster, (z<4) active galactic nuclei (AGN), and cosmic background survey sci

Background Semaglutide is a novel glucagon-like peptide-1 (GLP-1) analogue, suitable for once-weekly subcutaneous administration, in development for treatment of type 2 diabetes. We assessed the efficacy and safety of semaglutide versus the dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin in patients with type 2 diabetes inadequately controlled on metformin, thiazolidinediones, or both. Method

Primary defence against invading microorganisms depends on a functional innate immune system and the complement system plays a major role in such immunity. Deficiencies in one of the components of the complement system can cause severe and recurrent infections, systemic diseases, such as systemic lupus erythematosus (SLE) and renal disease. Screening for complement deficiencies in the classical or

The Swedish Spine Register enables monitoring of surgical activities focusing on changes in trends over time, techniques utilized and outcome, when implemented in general clinical practice. Basic requirements for a prosperous register are unity within the profession, mainly patient-based documentation and a well functioning support system. This presentation focuses on the development and design of

Popular Abstract in Swedish Vårt immunförsvar måste ständigt vara redo att försvara oss mot angrepp utifrån. Det måste kunna agera selektivt för att skydda oss mot främmande mikroorganismer som virus och bakterier. Om immunförsvaret istället missbedömer kroppens egna celler för att vara inkräktare och attackerar dessa, inträffar det vi kallar autoimmunitet. De autoimmuna sjukdomarna har ökat överaAim: The general objective of the present research was to study the association between type 1 diabetes and celiac disease, and the effects of dietary gluten on the risk of developing type 1 diabetes. More specific aims were as follows: to estimate the prevalence of celiac-disease-associated autoantibodies in children with type 1 diabetes; to study the connection between non-HLA genetic risk marke

Inverted pendulums are very well suited to investigate friction phenomena and friction compensation because the effects of friction are so clearly noticeable. This paper analyses the effect of friction on the Furuta pendulum. It is shown that friction in the arm drive may cause limit cycles. The limit cycles are well predicted by common friction models. It is also shown that the amplitudes of the

Composition of azurophil and specific granules from human polymorphonuclear neutrophils and granules from eosinophils is presented. Biosynthesis of the granule proteins is discussed in detail with particular emphasis on neutrophil myeloperoxidase (MPO) and eosinophil cationic protein (ECP).