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Molecular evolution of a C5aR antagonist against inflammatory disease

New anti-inflammatory drugs with fewer adverse effects than existing drugs may prove to be useful in the treatment of several inflammatory disorders. A critical step in acute inflammation is the infiltration of neutrophils into tissues. Therefore, molecules that target and inhibit this early inflammatory event are attractive to engineer to suit medical needs. The Chemotaxis Inhibitory Protein of

Lipoteichoic acid is the major cell wall component responsible for surface hydrophobicity of group A streptococci

The contribution of lipoteichoic acid (LTA) to the hydrophobic surface properties of group A streptococci was investigated in aqueous dextran-polyethylene glycol two-phase systems. Enzymatic digestions were performed to characterize the hydrophobic surface structure. The results obtained indicated that LTA is a major factor responsible for the hydrophobic character of the cell surface of group A s

The influence of Poisson's ratio on the excitability of the first higher symmetric (S1) zero-group velocity Lamb mode.

The impact echo (IE) method is widely used in non-destructive testing of concrete plate like structures but has proved difficult to apply on asphalt pavements. Observed low IE resonance amplitudes on asphalt have been attributed to larger material damping but the present study shows that it may also be an effect from a larger Poisson's ratio. The IE frequency corresponds to the stationary resonanc