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The phenotype of human immunodeficiency virus type 1 (HIV-1) commonly evolves between and within infected individuals, at virus transmission, and during disease progression. This evolution includes altered interactions between the virus and its coreceptors, i.e., chemokine receptors, as well as mannose C-type lectin receptors (CLRs). Transmitted/founder viruses are predominantly restricted to CCR5

Previous data have indicated that IL-21 and/or IL-21R are crucial for the differentiation of naïve T cells into Th17 cells and also play a key role in the development of autoimmune disease. Given this, IL-21 and/or IL-21R are potential targets for therapy of such diseases; however, a study in this issue of the European Journal of Immunology, provides a new twist in the story as it is now shown tha

The arthritis-susceptible DA rat is one of the most commonly used rat strains for genetic linkage analysis and is instrumental for the identification of many genetic loci. Even though DA rats were kept as inbred lines at different institutes and suppliers, it became obvious that the various breeding stocks differed genetically. To be able to compare the results from different linkage studies it is

This paper reports speech articulator gestures in Swedish, Bulgarian, and Greenlandic to study universal and language-specific components in articulation. This work is based on analysis of movements of individual articulators from x-ray motion films of speech, and continues from previous reports from this study by Wood [J. Phon. 7, 25–43 (1979); 19, 281–292 (1991); Proc. 3rd Conf. I.C.P.L.A., 191–

Swedish translation (by B. Stolt) of select sermons by John Tauler (c. 1300-1361). A selection was made from among the authentic texts in Middle German.

Maps of the MT-saturation as derived in FLASH-based multi-parameter mapping (MPM) are largely corrected for effects of flip angle inhomogeneity. Here, we present a heuristic model for residual effects of B1+ that is rooted in the dynamics of macromolecule saturation. Model parameters were validated for brain tissues by variation of the MT-pulse flip angle in an established MPM protocol. White and

Ett hållbart och acceptabelt pensionssystem måste utformas utifrån personliga förutsättningar och förhållanden i arbetslivet, så att fler klarar att arbeta i högre ålder. Att enbart genom ekonomiska åtgärder höja pensionsåldern är inte långsiktigt hållbart, skriver 54 forskare.DEBATT | PENSIONForskning visar att cirka var fjärde har en diagnos eller skada orsakad av sitt arbete. Detta gör arbetsor

I propose that the evolution of teaching has been central in extending manipulative intentions. Demonstrating may be the evolutionarily first form of expression that is productive, ostensive, and involves informative intention. Demonstration also involves theory of mind. Then pantomime goes a step further and involves a communicative intention. Pantomime can thereby function as displaced communica

The study concludes that there were contacts between Birka and western Finland throughout more or less the whole existence of the town. The earliest evidence of these contacts is from the 760s and the latest from the middle of the tenth century. Unlike other eastern material in Birka, which became much more frequent during the second half of the ninth century the contacts with Finland were constan