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Galactose C3-triazole derivatives were synthesized by Cu(I)-catalyzed cycloaddition between acetylenes and galactose C3-azido derivatives. Evaluation against galectin-3, 7, 8N (N-terminal) and 9N (N-terminal) revealed 1,4-disubstituted triazoles to be high-affinity inhibitors of galectin-3 with selectivity over galectin-7, 8N, and 9N. Conformational analysis of 1,4-di-and 1,4,5-tri-substituted gal

Introduction: Tension band wiring of olecranon fractures has high reported rates of complications and reoperations. We aimed to compare classic tension band wiring to cerclage fixation without K-wires in the treatment of displaced olecranon fractures in elderly patients. The primary outcome was reoperation. Secondary outcomes included complications and patient reported outcomes. Outcomes following

The EU’s practice of exporting its acquis to third countries is increasingly coupled with the integration of third countries in the work of the Union’s agencies. The reasons for including third countries vary, as do the forms and intensity of the cooperation. The aim of this study is to assess the possibilities for non-EU member states, in particular those that adopt and implement EU acquis in the

Data rate requirements for cellular communications are expected to increase 1000–fold by 2020, compared to 2010. This is mainly because of the rapid increase in the number of wireless devices and data hungry applications per–device. This creates a formidable bandwidth crisis. Milimeter–wave (mmWave) systems with massive multiple–input multiple–output (MIMO) operation are two complementary concepts

BACKGROUND: The risk of breast cancer among hypertensive patients who use beta-blockers has attracted attention. However, the evidence is inconsistent and investigation of the dose-specific associations for subtypes of beta-blockers are limited.METHODS: By incorporating Swedish national registers, breast cancer risk was estimated in women with hypertension who used nonselective beta-blockers and b

The chapter concerns the supranational place branding by the Nordic countries. Earlier studies highlighlight the obstacles in supranational place branding initatives and the challanges for involved stakeholders’ to agree as geographical size and complexity increases. The branding initiative of the Nordic countries, executed by the Nordic Council of Ministers, represents a rare example of a group o

The material evidence left from the cult of Sabazios is meagre, apart from sculpted bronze hands dating to the Roman Empire. The hand is held in a certain pose, the so-called benedictio Latina gesture, and the hand was often covered with depictions of various objects and symbols. The bronze hands were probably attached to staffs and carried around in processions. This practice most likely spread v

This study examined the control of voice intensity using acoustic and aerodynamic recordings. A total of 34 subjects participated half of them with and half without song training, 21 females and 13 males. The subjects produced the syllable sequence /papapa/ while the acoustic signal, the oral air flow and the oral air pressure were recorded using the Kay-Pentax Phonatory Aerodynamic System. The or

The Sustainable Business Model Canvas (SBMC) offers a useful tool for business model design, as it manages to integrate all three dimensions of sustainability without distinguishing between three different layers (economic, environmental, and social). This paper presents the application of SBMC in a real study case of a one-stop-shop (OSS) for the renovation of single-family houses operating inKro

This chapter begins by providing a general contextualisation of hate speech and the controversies around it. It then asks two questions: Is Holocaust denial a form of hate speech? If the answer is positive, should Holocaust denial be banned?The second section explains what is hate speech. The third section is concerned with the relationship between hate speech and hate crime. The fourth section di

This chapter discusses the inaugural dissertation of the first ex officio professor of natural law in Denmark, Andreas Hojer: the 1735 Dissertatio iuris publici universalis de eo quod iure belli licet in minores. In doing so, it seeks to shed light on a little-known figure in the early Danish enlightenment, albeit one who was very influential in his day. It explains why Hojer chose what, on the fa

Mammalian metabolism comprises a series of interlinking pathways that include two major cycles: the folate and methionine cycles. The folate-mediated metabolic cycle uses several oxidation states of tetrahydrofolate to carry activated one-carbon units to be readily used and interconverted within the cell, which are required for nucleotide synthesis, methylation and metabolism, particularly for pro

This thesis is a combined critical, biographical, and bibliographical study of American poet Frank Stanford (1948-1978). A prodigious, prolific poet's poet, Stanford is a long-underappreciated artist whose unwavering legacy, in recent years, has grown to be an undeniable force in contemporary American poetry. Stanford was an adoptee, and this study investigates his preoccupation with his loss

Den här uppsatsen behandlar frågan om det ondas problem, inom teologiska och religionsvetenskapliga kretsar mer känt som Teodicéproblemet. Till skillnad från liknande uppsatser som rör det ondas problem kommer den här uppsatsen inte att behandla frågan gällande Guds existens, ej heller kommer uppsatsen att behandla huruvida det ondas problem är ett bra argument mot Guds existens. Här kommer istäThis paper will address the issue of:” Why God allows evil”, also known as theodicy. Unlike similar essays concerning this question, this paper will not address the question in relation to the existence of a God, nor shall it address whether the problem of evil is a good argument against this existence. This paper will focus upon the function of evil with a focus on Judeo-Christian contexts. The

In this thesis I investigate the notion of imagination in Romantic thought and in the visual art of William Blake with the aim of making a contribution to theological methodology. In early German Romanticism, as well as in the art of William Blake, the concept of imagination plays a central role in the relationship between the Absolute and the perceiving and knowing subject. My thesis takes its st