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HAMLET (human alpha-lactalbumin made lethal to tumor cells) interacts with multiple tumor cell compartments, affecting cell morphology, metabolism, proteasome function, chromatin structure and viability. This study investigated if these diverse effects of HAMLET might be caused, in part, by a direct effect on the ATP synthase and a resulting reduction in cellular ATP levels. A dose-dependent reduc
Psychological disability caused by stress is likely to affect cognitive and emotional functions, such as memory, attention, concentration, and decision making. These functions are essential in a train driver’s work, who is responsible for his or her own and others’ safety, and for this purpose requires optimal work capacity. Eighteen train drivers, 40 – 56 years old, most of them with long work ex
We have traced the Galactic thick disk to its, to date, highest metallicities. Based on high-resolution spectroscopic observations of 187 F and G dwarf stars that kinematically can be associated either with the thin disk (60 stars) or with the thick disk (127 stars), we find that the thick disk stars reach at least solar metallicities, and maybe even higher. This finding is independent of the U_LS
Trust and Credibility as Basis of Corporate Social Responsibility
HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) is the first member in a new family of protein-lipid complexes with broad tumoricidal activity. Elucidating the molecular structure and the domains crucial for HAMLET formation is fundamental for understanding its tumoricidal function. Here we present the low-resolution solution structure of the complex of oleic acid bound HAMLET, derived
Galectin-4 belongs to a subfamily of galectins composed of two carbohydrate recognition domains within the same peptide chain. The two domains have all the conserved galectin signature amino acids, but their overall sequences are only approximately 40% identical. Both domains bind lactose with a similar affinity as other galectins, but their respective preferences for other disaccharides, and larg
3-Deoxy-3-amino-beta-D-talopyranosides have been synthesized for the first time. The amines were obtained from galactopyranosides through 2,3-anhydrogulosides that were opened to idosides followed by an oxidation/reductive amination sequence. From the amines, 11 corresponding 3-deoxy-3-arylamido-beta-talopyranosides have been synthesized and evaluated as inhibitors against galectin-1, -2, -3, -4C,
Famous for its many New Kingdom stelai and funerary shrines, Speos of Horemheb and magnificent quarries, this paper presents a preliminary report on a lesser acknowledged feature of Gebel el Silsila: its quarry marks. Focusing here on the northern section – Partition B – of Silsila East’s Main Quarry, seventeen individual quarry faces display totally 376 quarry marks, which have been divided into
Many functions of galectin-3 entail binding of its carbohydrate recognition site to glycans of a glycoprotein, resulting in cross-linking thought to be mediated by its N-terminal non-carbohydrate-binding domain. Here we studied interaction of galectin-3 with the model glycoprotein asialofetuin (ASF), using a fluorescence anisotropy (FA) assay to measure the concentration of free galectin carbohydr
The concept of ‘industrial society’ is generally used for a type of social organization based on mass production of commodities. This type of societies began to dominate Western Europe toward the end of the eighteenth century, reflecting a strategy to expand export production in order to appropriate embodied labor and resources from elsewhere in the world-system. Perceived as progress and ‘develop
