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Variation in gamma dose rate in different locations following the Chernobyl accident

Radionuclides from the Chernobyl accident were released and dispersed during a limited period of time, but under different weather conditions. As a result the radionuclides were unevenly distributed on the ground. During the years the initial deposition has been altered at some locations by different processes, but remains relatively unchanged in others. Here we report on the current inhomogeneous

Aspects of Organizational Psychology and Innovation in Air Traffic Control

In order to adapt to new conditions that increasing air traffic volumes bring forward, the Swedish Air Navigation Services (ANS) is going through a process of change. In order to meet the new conditions it will be necessary to be more efficient in the work of handling the air traffic. New conditions bring forward new demands, not only on technology and methods used, but also on organizational stru

Values about management in client related and not client related jobs: a comparison between a ward in the geriatric care and in industrial company.

Values among individuals having client-related jobs and organisations in client related sectors might differ from values in their counterparts in jobs and sectors that are not client-related. It is possible that jobs that include interactions with other people demand more developed moral thinking. This report is a description of differences that has been found in a comparison between a ward in the

Direkt profil: A system for evaluating texts of second language learners of French based on developmental sequences

Direkt Profil is an automatic analyzer oftexts written in French as a second lan-guage. Its objective is to produce an eval-uation of the developmental stage of stu-dents under the form of a grammaticallearner profile. Direkt Profil carries outa sentence analysis based on developmen-tal sequences, i.e. local morphosyntacticphenomena linked to a development in theacquisition of French.The paper pre

The role of the MAP- and SAP- kinase pathways in the survival, proliferation and death of Schwann cells of the injured sciatic nerve.

Popular Abstract in Swedish Den här avhandlingen behandlar främst Schwannceller och hur de reagerar på en nervskada. Schwannceller omger alla nervtrådar i det perifera nervsystemet det vill säga det nervsystem som ligger utanför hjärna och ryggmärg och innerverar armar, ben, händer och fötter och så vidare. Schwannceller och ger dessa tillgång till de näringsämnen de behöver. De städar också upp sThis thesis concerns alterations in signal transduction in Schwann cells as a response to nerve injury as well as their survival, proliferation and death. Enzymes and transcription factors belonging to the mitogen activated protein kinase (MAPK) and the stress activated protein kinase (SAPK) pathways were studied. This included the extracellular-signal-regulated kinase 1/2 (ERK1/2), c-Jun N-termin

Modelling the gold market, explaining the past and assessing the physical and economical sustainability of future scenarios

By using an integrated dynamic model we are able to reconstruct the supply and gold price of the past (1920-2010) and this is used to predict the future supply of gold to the market and to make a forecast of the goldprice 2010-2100. The model was validated against field data for the period 1920-2010 and it performs well. The model GOLD is implemented in the STELLA® software and the model described

Neural Network Ensembles and Combinatorial Optimization with Applications in Medicine

Popular Abstract in Swedish Inom medicin, och inom många andra tillämpningar, är uppgiften ofta att utifrån en serie observationer ge ett jakande eller nekande svar på en viss fråga. Exempelvis måste en läkare avgöra om en patient med bröstsmärtor lider av akut hjärtinfarkt eller inte. Artificiella neurala nätverk är en sorts datorprogram som själv förmår "lära" sig att svara på sådana frågor. NäArtificial neural network (ANN) and combinatorial optimization algorithms are developed, and applied to the medical domain. A novel method for training an ensemble of ANN is presented, based on random weight updates alternated with replication of networks with low error. The evolution of the ensemble is explored, with particular emphasis on its diversity and internal correlation. The performance

Mucosal receptors involved in pathogen recognition and host defence

Urinary tract infection is the most common infection in man. P fimbriae are virulence factors of uro-pathogenic Escherichia coli. They are expressed by 70-90 % of acute pyelonephritis isolates and up to 100% of the most virulent isolates that cause bacteremia. This thesis concerns the interaction between P fimbriae and the urinary tract mucosa, and the host receptors involved in fimbrial recognit

Lipids as cofactors in protein folding: Stereo-specific lipid-protein interactions are required to form HAMLET (human alpha-lactalbumin made lethal to tumor cells).

Proteins can adjust their structure and function in response to shifting environments. Functional diversity is created not only by the sequence but by changes in tertiary structure. Here we present evidence that lipid cofactors may enable otherwise unstable protein folding variants to maintain their conformation and to form novel, biologically active complexes. We have identified unsaturated C18 f

T cell surface redox levels determine T cell reactivity and arthritis susceptibility.

Rats and mice with a lower capacity to produce reactive oxygen species (ROS) because of allelic polymorphisms in the Ncf1 gene (which encodes neutrophil cytosolic factor 1) are more susceptible to develop severe arthritis. These data suggest that ROS are involved in regulating the immune response. We now show that the lower capacity to produce ROS is associated with an increased number of reduced

Apical sorting by galectin-3-dependent glycoprotein clustering

Epithelial cells are characterized by their polarized organization based on an apical membrane that is separated from the basolateral membrane domain by tight junctions. Maintenance of this morphology is guaranteed by highly specific sorting machinery that separates lipids and proteins into different carrier populations for the apical or basolateral cell surface. Lipid-raft-independent apical carr

Functional analysis of the alpha10beta1 integrin

Popular Abstract in Swedish Brosk är en speciell typ av vävnad, som bl.a. finns på våra ledytor, där det fungerar som ett stötdämpande och skyddande lager för benet. Broskets viktiga egenskaper framstår klart vid sjukdomar, som artros, där brosket på ledytor har förstörts och benet blottläggs, vilket resulterar i en permanent smärta. Brosk produceras av den enda celltyp som finns i broskvävnaden; The aim of this thesis was to study the function of the integrin a10b1. Integrins mediate signals between cells and their environment and regulate several cellular processes such as cell migration, proliferation and differentiation. The a10b1 integrin is expressed mainly by chondrocytes, the only cell type present in cartilage, and facilitates binding of the chondrocytes to the extracellular matri

Colloidal systems in DNA packaging

The interaction between DNA and cationic cosolutes- multivalent ions, cationic surfactants and cationic macromolecules- has direct biological implications and is also foreseen to have a number of applications, in particular for transfection and protection and purification of DNA. We have during the last few years established a broad physico-chemical research program on various mixed systems of DNA