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Synthesis of galactose-mimicking 1H-(1,2,3-triazol-1-yl)-mannosides as selective galectin-3 and 9N inhibitors.

1H-[1,2,3]-Triazol-1-yl mannosides have been synthesized as inhibitors for the beta-galactoside-binding family of galectin proteins. Easier synthetic access to C1 in mannose, as compared to C3 in galactose, for attachment of affinity-enhancing triazoles rendered a synthetic advantage. The best mannose-derived inhibitor for galectin-9N, 4-benzylaminocarbonyl-1H-[1,2,3]-triazol-1-yl beta-D-mannopyra

Recall and perceived naturalness of asynchronous speech and gesture

Part of the justification for an integrated view of speech and gestures ( (( is their temporal coordination. Gestures generally coincide with or precede, but rarely follow lexical affiliate (McNeill, 1992). How synchrony impacts listeners remains less explored, despite potential relevance for video communication and virtual conversational agents. ERP studies suggest that temporal alignment affects

Political comedy engagement : Genre work, political identity and cultural citizenship

Politisk komedi är en hybridgenre där politiska nyheter och analyser blandas med komedi och underhållning. Allt eftersom politisk komedi ökar i popularitet – i de flesta medieformer och nationella kontexter – arbetar forskare med att förstå dess roll i relation till medborgarskap, och det kan konstateras att genren utmanar den vetenskapliga förståelsen av politiska medier och medborgarskap. Denna Political comedy is a hybrid genre that mixes political news and analysis with comedy and entertainment. As it becomes more and more popular in most media forms and national contexts, researchers struggle to understand its role in relation to other types of political media, and of citizenship; in this sense, it challenges scholarly conceptualisation of political media and citizenship. Thus, this t

Prediction of endometrial malignancy in women with postmenopausal bleeding and sonographic endometrial thickness ≥ 4.5 mm.

OBJECTIVE: To build mathematical models to evaluate the individual risk of endometrial malignancy in women with postmenopausal bleeding and sonographic endometrial thickness ≥ 4.5 mm using clinical data, sonographic endometrial thickness and power Doppler ultrasound findings. METHODS: Of 729 consecutive patients with postmenopausal bleeding, 261 with sonographic endometrial thickness ≥ 4.5 mm and

Minskat matsvinn – lättare sagt än gjort?

Titel: ”Minskat matsvinn – lättare sagt än gjort?” Seminariedatum: 14 januari 2016 Kurs: FEKH29, Examensarbete på marknadsföring på kandidatnivå, 15 hp Författare: Sara Berg (900724), Emma Forssman (910816) och Shazia Khawri (910202) Handledare: Annette Cerne Nyckelord: Matsvinn, Consumer Social Responsibility, attityder, beteenden, the Theroy of Reasoned Action, the Attitude-Behavior Gap Syfte: DTitle: “A decrease in food waste – easily said than done?” Seminar date: January 14th, 2016 Course: FEKH29, Degree Project in Marketing, Undergraduate Level, 15 ECTS Authors: Sara Berg (900724), Emma Forssman (910816) och Shazia Khawri (910202) Advisor: Annette Cerne Keywords: Food waste, Consumer Social Responsibility, attitudes, behavior, the Theroy of Reasoned Action, the Attitude-Behavior Gap

Waiting For Heart Surgery.

Popular Abstract in Swedish Att ha en allvarlig hjärtsjukdom är oftast förknippat med oro och rädsla. När det bestäms att patienten ska genomgå en planerad hjärtoperation, kan det vara avgörande för patientens och de närståendes välbefinnande hur de bemöts av all hälso- och sjukvårdspersonal, som de kommer i kontakt med under väntetiden samt vilket stöd de då upplever. Att korrekt och saklig inforPatients waiting for cardiac surgery often consider the period from the decision for surgery to the time for the operation as long, heavy and dreary. Therefore, it is important that patients are supplied with structured oral and written information regarding their disease and its treatment, so that they are able to understand and discuss the forthcoming operation, the risk of complications and the

The Lutheranized Beginnings of Swedish Fable History

The paper discusses how the early reception in Swedish of the Aesopic fable was filtered through German Lutheranism. The main focus of the paper is on the country’s very first vernacular fable collection, Hundrade Esopi Fabler (A Hundred Fables of Aesop), published in Stockholm in 1603. This volume is a faithful translation of the German collection Hundert Fabeln aus Esopo, composed in the 1570s b

Developing countries and emergency safeguard measures in world trade law

Before going into details and regulations behind the safeguard measures it's important to understand the basic starting point. The members of WTO all agree to have tariffs at a certain level and the member countries are prohibited to raise the tariffs above this level. This makes the system predictable&semic every one knows the tariff levels. Speaking in a broad sense one can say that this

Att se i blindo

Uppsatsen undersöker synförlustens anledningar och innebörder i fyra verk: "Konung Oidipus" och "Oidipus i Kolonos" av Sofokles, "The Country of the Blind" av H. G. Wells, samt "Blindheten" av José Saramago. Gemensamt för samtliga studerade verk är synförlust, och analyserna har fokuserats på denna synförlusts respektive anledningar och innebörder, synförlus

Human alpha-lactalbumin made lethal to tumor cells (HAMLET) kills human glioblastoma cells in brain xenografts by an apoptosis-like mechanism and prolongs survival.

Malignant brain tumors present a major therapeutic challenge because no selective or efficient treatment is available. Here, we demonstrate that intratumoral administration of human α-lactalbumin made lethal to tumor cells (HAMLET) prolongs survival in a human glioblastoma (GBM) xenograft model, by selective induction of tumor cell apoptosis. HAMLET is a protein-lipid complex that is formed from α

A story about how MR-imaging grew up in Lund.

Ett av mina första uppdrag som nybliven professor i Medicinsk Strålningsfysik vid Lunds Universitet var att i slutet av april 1981 åka till München för att delta i en Europeisk (EU) workshop om möjligheterna att reducera patient bestrålning vid röntgendiagnostik. Av deltagarna från Storbritannien framkom att man på flera håll i Storbritannien utvecklade metoder för medicinsk avbildning utan röntge

Development of a core capability framework for qualified health professionals to optimise care for people with osteoarthritis : an OARSI initiative

Objective: Develop a generic trans-disciplinary, skills-based capability framework for health professionals providing care for people with OA. Design: e-Delphi survey. An international inter-professional Delphi Panel (researchers; clinicians; consumer representatives) considered a draft framework (adapted from elsewhere) of 131 specific capabilities mapped to 14 broader capability areas across fou

Standardisation of nailfold capillaroscopy for the assessment of patients with Raynaud's phenomenon and systemic sclerosis

Capillaroscopy is a non-invasive and safe tool which allows the evaluation of the morphology of the microcirculation. Since its recent incorporation in the 2013 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria for systemic sclerosis together with its assessed role to monitor disease progression, capillaroscopy became a ‘mainstream’ investiga