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We report four previously undescribed families with germline BRCA1-associated protein-1 gene (BAP1) mutations and expand the clinical phenotype of this tumor syndrome. The tumor spectrum in these families is predominantly uveal malignant melanoma (UMM), cutaneous malignant melanoma (CMM) and mesothelioma, as previously reported for germline BAP1 mutations. However, mutation carriers from three new
Although fever (a closely regulated increase in body temperature in response to infection) typically is beneficial, it is energetically costly and may induce detrimentally high body temperatures. This can increase the susceptibility to energetic bottlenecks and risks of overheating in some organisms. Accordingly, it could be particularly interesting to study fever in small birds, which have compar
Initial viral decay rate may be useful when comparing the relative potency of antiretroviral regimens. Two hundred twenty-seven ART-naive patients were randomized to receive efavirenz (EFV) (n=74), lopinavir/ritonavir (LPV/r) (n=77), or atazanavir/ritonavir (ATV/r) (n=79) in combination with two NRTIs. The most frequently used NRTI combinations in the EFV and ATV/r groups were the nonthymidine ana
The zinc(II) coordination chemistry of the bioinspired bis(tetradentate) ligand 3,5-bis{bis[2-(1-methylimidazolyl)methyl]aminomethyl}pyrazole (L) was studied in detail both in solution and in the solid state. Six different species were determined in aqueous solution by means of potentiometry within the pH range 211, namely mononuclear [ZnH2L]4+, dinuclear [Zn2L]4+, [Zn2H1L]3+ and [Zn2H2L]2+, as we
In addition to being a key criterion of the sustainable development proviso, for business, the integration of social- and ecological considerations into decision-making is of growing importance for minimising future environmentally-related risk and associated economic costs, as well as gaining a share in growing markets favouring products and companies focusing upon social responsibility and ecolo
INTRODUCTION: Merkel cell carcinoma is a rare malignant cutaneous neoplasm that is locally invasive and frequently metastasizes to lymph nodes, liver, lungs, bone and brain. The incidence of Merkel cell carcinoma has increased in the past three decades.CASE PRESENTATION: A 65-year-old Caucasian man presented with a sudden onset of severe headache and a three-month history of balance disturbance. M
Little is known about the relative importance of mechanistic drivers of plant spread, particularly when long-distance dispersal (LDD) events occur. Most methods to date approach LDD phenomenologically, and all mechanistic models, with one exception, have been implemented through simulation. Furthermore, the few recent mechanistically derived spread models have examined the relative role of differe
Chondrocytes isolated from the Swarm rat chondrosarcoma were incubated in culture with [1-3H]glucose for 30 min to 8 h. Labeled proteoglycans were isolated, treated with borohydride under alkaline conditions, and the three complex sugar structures purified: N- and O-linked oligosaccharides and chondroitin sulfate chains. The amount of incorporated radioactivity into each component sugar was analyz
Among Simon Hall's influential contributions to historical archaeology are two research agendas: The need to focus attention on lower scalar levels of analysis, and broadening the concept of ceramic style to include less visible technological qualities. The latter is of particular importance to the stylistically bland and less decorated assemblages from the 18th and 19th centuries. Combining and d
The implementation of circular economy strategies, such as the reuse of building materials, represents a valid opportunity for the building and construction sector to diminish the consumption of raw materials and generate revenues and, thus, to contribute to the Sustainable Development Goals 11 and 12. However, the reuse of building materials is still limited. Previous studies suggest that one rea
Background: Therapies that could further prevent the development of heart failure (HF) and other cardiovascular and metabolic events in patients with recent myocardial infarction (MI) represent a large and unmet medical need. Methods: DAPA-MI is a multicenter, parallel-group, registry-based, randomized, double-blind, placebo-controlled phase 3 trial in patients without known diabetes or establishe
The categories and concepts in the existing official land-use maps have been under improvements over recent years; however, this study from Nordland, northern Norway, shows that they continue to pose several dilemmas when aiming to better capture the impacts of multiple land uses on reindeer herding. While these developments have done much to better communicate the presence of reindeer herding to
The perspective of the public sphere, despite its utility, has some gaps. Not least is its lack of sociological anchoring in the everyday lives and experiences of citizens. The text argues that we can illuminate the media's role in promoting or hindering participation in the public sphere by making use of the six-dimensional framework of civic cultures.
To obtain knowledge about combustion mechanisms operating in the ammoxidation of toluene, the formation of carbon oxides was studied over a Ti02(B)-supported vanadium oxide catalyst with monolayer loading. The partial pressures of reactants were varied and kinetic rate expressions, completely describing experimental data, were derived. A comparison of the expressions obtained with those for the fo
The EU has assumed ambitious targets and strategies for the promotion of renewable sources of energy (RES) binding to all its member states. This report examines the proposed EU-wide policy instrument designed to help achieve the targets on renewable electricity and heat - the trading of Guarantees of Origin (GO). It analyses the rise and fall of the GO trading proposal in the European policy-maki
A search for long-lived particles is performed using a data sample of 4.7 fb(-1) from proton-proton collisions at a centre-of-mass energy. root s = 7 TeV collected by the ATLAS detector at the LHC. No excess is observed above the estimated background and lower limits, at 95% confidence level, are set on the mass of the long-lived particles in different scenarios, based on their possible interactio
The Kalpha satellite spectra arising from the correlative multielectron processes accompanying K-shell photoionization of Ca, Ti and V were measured using a broad range crystal spectrometer. Multiconfiguration Dirac-Fock calculations were performed to interpret the observed,x-ray energies and the spectral line shape., The calculations agree fairly well with the experimental results. The variation
Background Both acute myocardial ischemia and reperfusion contribute to cardiomyocyte death in ST-elevation myocardial infarction (STEMI). The final infarct size is the principal determinant of subsequent clinical outcome in STEMI patients. In a proof-of-concept phase II trial, the administration of cyclosporine prior to primary percutaneous coronary intervention (PPCI) has been associated with a
