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Basal cell carcinoma cells show low proliferation rates at the invasive front and a concordant upregulation of the cdk-inhibitor p16, limiting proliferative capacity. Little is known about the mechanisms of p16 regulation in normal and malignant cells apart from that many transcription factors such as Ets1, Ets2, SP1, SP3, JunB and the polycomb protein Bmi1 have the potential to induce or repress

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BACKGROUND: Our aim was to describe changes in the volume and vascularization of both ovaries, the dominant follicle and the corpus luteum during the normal menstrual cycle using three-dimensional (3D) power Doppler ultrasound. METHODS: Fourteen healthy volunteers underwent serial transvaginal 3D ultrasound examinations of both ovaries on cycle day 2, 3 or 4, then daily from cycle day 9 until foll

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This thesis examines EU’s adoption of a human security approach and the extent to which it has been part of crisis management discourse as well as practice in the Sahel region of Africa. It tells the story of a maturing process for a core approach in EU security policy; that is, the story of human security and how the concept has evolved from a state of innocence to gradual experience and adolesc

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The European Union released an Artificial Intelligence (AI) regulation proposal in April 2021 aimed at laying down harmonised rules for AI circulating the Union market. The purpose of this study is to critically examine how accountability and individual, collective, and social harm was approached and framed by the proposal. Previous research has shown that AI and algorithmic bias and discriminatio

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The study has been based on semi-structured interviews with 10 customers who have chosen Kalmar municipality as homecare service provider. The interviews have been conducted in conjunction with customers granted home care and with a follow-up after one-two months. By examining and analyzing the customer’s expectations and experiences at an early stage when home-care services started and then follo

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Omni-channel retailing, the concept of offering consumers a seamless experience by integrating physical stores and online channels, is growing within the retail industry. This transformation has forced entire organizations to rethink their logistics network and fulfillment operations, which has resulted in an endeavor to work more cross-functionally in businesses. This shift makes the competence r

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Uppsatsen centrerar kring två aktuella frågor: anklagelser om sexuella övergrepp i FN:s fredsbevarande operationer, och konstruerandet av könsroller. De specifika frågeställningarna för uppsatsen är inledningsvis vilka könsroller som konstrueras i primärmaterialet, vilket innefattar tre årliga FN-rapporter. Den andra frågeställningen syftar till att utreda huruvida den konstruerade, militära masku

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Abstract The barnacle, Stephanolepas muricata, a commensal epibiont of cheloniid sea turtles, occurs frequently on the sea turtles of the Golfo Dulce, Pacific Costa Rica. The aim of this study was to quantify the occurrence of S. muricata on green and hawksbill sea turtles, to describe its major attachment locations and to investigate potential routes for barnacle exposure. In-water sampling of s

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This master thesis has been conducted at the Division of Combustion Engines under the Department of Energy Sciences, Faculty of Engineering at the Lund University. The purpose of this master thesis project is to create a computer based model of a Natural Gas Engine in order to raise its potential for updating a Volvo bus as well as creating a study of the improvement efficiency of the Miller Cycle

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Purpose: This thesis aims at understanding the relationship between regular transnational European supermarkets and their consumers regarding environmental expectations. Theoretical Perspective: This study gathers several theories, from the stakeholder’s perspective to the Say-Do gap, particularly for consumers. The constructed theoretical framework involves four angles such as CSR, retail sector

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In working to reduce this increasingly intensified effect of climate change, one of the key strategies employed by different countries around the world is to reduce Green House Gas (GHG) emissions from the energy sector. As they are one of the biggest contributors, the strategies include the employment of different mitigation actions and fading away from the conventional fossil fuel source to a mo

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Bumblebee abundance and diversity have been declining in the last few decades. Habitat change, mainly due to intensified agricultural practices, has been pointed out as the main driver in this process. Being central place foragers bumblebees are highly dependent on the landscape surrounding the nest and the resources available there. According to the optimal foraging theory bumblebee individuals i

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Det finns ett antal olika konkurrensregler inom den europeiska unionens regelverk. Den här uppsatsen behandlar artikel 102 som reglerar missbruk av en dominerande ställning. Varje konkurrensärende måste påbörjas med att en marknad avgränsas. Just då bedömningen avser artikel 102 förfaranden ter sig marknadsdefinitionen än viktigare. Vid avgränsningen av marknaden använder sig kommissionen av kvantWhen applying competition law within Europe, the first stage of the assessment is to define the relevant market. The relevant market is the field of the review, and is not an end in it self. The relevant market contains the information that the assessment is based on. There is a great importance in the assessment of the market, sometimes it is stated that the one who wins the market, wins the case

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The purpose of this study is to examine and understand how dominant gender attitudes are represented in the society and how they influence social institutions and processes, such as labor market and employment. Greater understanding of the several aspects of this phenomenon enables us to gain knowledge on how to deal with it for both the main actors in the labor market: jobseekers and employers. G

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In Saccharomyces cerevisiae, the Pho84 high-affinity transport system is the major phosphate transporter activated when the cells experience a limitation in external phosphate. In this study, we have compared the phosphate-responsive mechanism of cells expressing PHO84 with a Deltapho84 strain by use of a phosphate analogue, methylphosphonate, which was judged to be suitable for assessment of phos

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Knowledge concerning the normal aging of cerebral white matter will improve our understanding of abnormal changes in neurodegenerative diseases. The microstructural basis of white matter maturation and aging can be investigated using diffusion tensor imaging (DTI). Generally, diffusion anisotropy increases during childhood and adolescence followed by a decline in middle age. However, this process

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Companies aiming to be 'sustainability leaders' in their sector and governments wanting to support their ambitions need a means to assess the changes required to make a significant difference in the impact of their whole sector. Previous work on scenario analysis/scenario planning demonstrates extensive developments and applications, but as yet few attempts to integrate the 'triple bottom line' co

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This paper communicates the results of a reassessment of the original burial position of the Barum burial, Scania, Sweden, dated to c. 8,700 years ago. Based on a thorough analysis of the photographs from Folke Hansen’s excavation, it is concluded that the body was placed in an upright sitting position. The notion that the body was leaning backwards is based on a faulty interpretation of the origi

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Rangelia vitalii is a protozoon that causes diseases in dogs, and anemia is the most common laboratory finding. However, few studies on the biochemical changes in dogs infected with this protozoon exist. Thus, this study aimed to investigate the biochemical changes in dogs experimentally infected with R. vitalii, during the acute phase of the infection. For this study, 12 female dogs (aged 6-12 mo