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Popular Abstract in Swedish Titeln på den här avhandlingen är ”Nukleinsyror som läkemedel och mål för läkemedel, med fokus på anticanceraktiva platinaföreningar och små interferande RNA”. Nukleinsyror är mer kända som sina förkortningar DNA och RNA. Anticanceraktiva platinaföreningar är en typ av läkemedel mot cancer. Små interfererande RNA är en slags reglermekanism för hur mycket av ett visst prTo ensure that patients receive a safe and effective treatment, it is important to understand how drugs interact with and affect molecules within a cell. Here, evaluation of platinum based drugs and their ability to interfere with nucleic acid functions is presented. The main focus of this thesis has been to evaluate whether siRNA efficiency can be modified by two clinically used anticancer active

K2[Pd(NO3)4] has been prepared and its crystal structure determined by use of a CAD-4 diffractometer with monochromatic Mo Kα radiation. The space group is P21/c with Z = 4; a= 7.940(2); b = 15.469(4); c = 9.453(2) Å; β = 91.10(3)°. The refinement converged to R = 0.023. The structure contains discrete complexes of [Pd(NO3)4]2− with pseudo-symmetry C4. Pd coordinates four oxygens from different un

Context: Epigenetics may contribute to sex-specific differences in human liver metabolism. Objective: To study the impact of sex on DNA methylation and gene expression in human liver. Design/Setting: Cross-sectional, Kuopio Obesity Surgery Study. Participants/Intervention: We analyzed DNA methylation with the Infinium HumanMethylation450 BeadChip in liver of an obese population (34 males, 61 femal

Small B cell lymphoid neoplasms are the most common lymphoproliferative disorders involving peripheral blood (PB) and bone marrow (BM). The Bone Marrow Workshop (BMW) organized by the European Bone Marrow Working Group (EBMWG) of the European Association for Haematopathology (EAHP) during the XVIIth EAHP Meeting in Istanbul, October 2014, was dedicated to discussion of cases illustrating how the r

Sedan våren 2014 har delar av Ukrainas östra territorium kontrollerats av separatister som understödjs av Ryssland. Separatisterna har utropat nya folkrepubliker, som dock inte erkänts som nya stater av det internationella samfundet. På grund av separatisternas territoriella kontroll kan Ukraina inte säkerställa att Europakonventionen om de mänskliga rättigheterna efterlevs och respekteras i regioWhen Ukraine lost control over parts of its eastern territory to separatists in 2014, it indicated that it no longer had the ability to fulfil its obligations under the European Convention of Human Rights in regards to that area. However, although the separatists have proclaimed their own states, these are not recognised by the international community. Since the ECHR only applies to state parties

Liquefied Petroleum Gas (LPG) is a flammable mixture of hydrocarbon gases, mainly propane and butane, used for various heating purposes and as vehicle fuel. This thesis focuses on examining the LPG market, evaluating a couple of driving factor hypotheses for the propane price and developing a model for forecasting of future propane prices in North-West Europe, both on daily and monthly horizons. I

Statement of purpose: The purpose of this report is to enhance the understanding and knowledge of the collaborative destination marketing process. Questions of issues: How do Helsingborg and Stockholm collaborate and compete within the Cruise Baltic Project? What preconditions, motivations and outcomes related to the Cruise Baltic Project exist in Helsingborg and Stockholm? How do they differ? Met

Rodrigo Roa Duterte was elected president of the Philippines in 2016. He launched a violent War on Drugs only one day after his assumption of the presidency. In his inaugural speech, Duterte described his adherence to the rule of law as uncompromising. At the same time, he has publicly promised to kill anyone who is involved in the drug business and encouraged the police and ordinary citizens to d

Att människan orsakat och orsakar klimatförändringar betraktas numera som en realitet. Färska klimatforskningsresultat angående klimatrelaterade risker, t.ex. värmeböljor, översvämningar, torka etc., har medfört ett ökat fokus på att begränsa höjningen av den globala medeltemperaturen så att den inte överskrider 1,5°C-målet i Parisavtalet. För närvarande uppskattas dock att det målet kommer överskAnthropogenically caused climate change is now considered a reality. Recent climate scientific insights regarding climate-related risks, e.g. heat-waves, floods, droughts etc., have generated an increased focus on limiting the rise in global mean temperature to not exceeding the 1.5°C target enshrined in the Paris Agreement. Currently however, that target is estimated to be exceeded somewhere betw

The wind power industry has long remained passive on broader sustainability issues, grounded in the perception that the industry is inherently linked with environmental sustainability. Within the past 5 years, there has been a dramatic change in the stakeholder and corporate perception of sustainability. Increasing expectations from stakeholders are pressuring wind OEMs to transition and advance c

The presumption of parental liability is an important tool for the Commission, enabling it to hold parent companies jointly and severally liable with their subsidiaries. Parent companies claim however, that they cannot rebut the presumption and are thus rendered strictly liable for their subsidiaries’ conduct. Due to the fact that parent companies repeatedly failed rebutting the presumption with e

EU:s koncentrationsförordning syftar till att skydda konkurrensen på den inre marknaden från skada som orsakas av betydande strukturella förändringar, genom att säkerställa att företagsförvärv och fusioner leder till ökad tillväxt och en högre levnadsstandard inom EU. Denna uppsats undersöker det rättsliga ”vakuum” som uppstår utanför förordningens tillämpningsområde, samt hur den praktiska tillämThe EU Merger Regulation aims to protect the common market from lasting damage to competition caused by significant structural changes, by ensuring that mergers and acquisitions ultimately lead to improved growth and a higher standard of living within the EU. This thesis examines the regulatory gap outside the scope of the EU Merger Regulation, and how the practice of EU merger control has evolved

This thesis investigates the semiotic foundations of recurrent gestures through a cross-cultural study of the Two-Handed-Alternation-Sagittal (2HAS) gesture in Japanese and Swedish. Drawing on the Motivation & Sedimentation Model (MSM)––a cognitive-semiotic model of meaning-making––the study explores how recurrent gestures emerge from the dynamic interplay between embodiment and sedimentation.

Denna uppsats syftar till att undersöka hur EU-rätten har påverkat svenska arbetstagarorganisationers möjligheter att använda sig utav stridsåtgärder och vilka effekter denna påverkan kan ha på den svenska arbetsmarknadsmodellen. För det första måste det sägas att EU-domstolens genom Laval och Viking har gjort det svårare för arbetstagarorganisationer att vidta stridsåtgärder då domstolen ansett aThis thesis has the aim of investigating how EU-law has affected the legal position regarding Swedish trade union’s possibilities of undertaking industrial actions. It also aims at determining whether the influence of EU-law on the right to undertake industrial actions has had any effects on the Swedish model. According to CJEU’s judgements in Laval and Viking it must be said that the possibilit

This paper aims to test the impact of a changing dimensional structure on the party system polarization for several countries in Western Europe. It will focus on research on why new parties, and in particular radical right parties, have been able to find ground in Europe. In particular, it will quantitatively test how this might correspond with an increase in the polarization of the new dimension

Course evaluation Physical Geography and Ecosystem Science LU Course Summary for Remote sensing for landscape studies, NGEA03, vt 2021 Course coordinator: Ulrik Mårtensson Teachers in the course: Anna Maria Jönsson, Jonas Ardö Number of students: 15 registered students Grade distribution: 1 UK, 0 G, 14 VG. Evaluation Summary of the course evaluation Number of survey responses: 12, of which is 80 %

https://www.nateko.lu.se/sites/nateko.lu.se/files/2023-03/NGEA03%20course%20evaluation%20summary_0.pdf - 2026-07-12

2020-01-31_SE 1 Strategisk plan för det strategiska forskningsområdet (SFO) ”Epidemiology for Health” (EpiHealth) under perioden 2020-2025 Föreliggande strategiska 5-års plan bygger på den tidigare planen för åren 2017-2021 som antagits av styrelsen för SFO EpiHealth enligt protokollfört styrelsemöte den 26 januari 2017. Grunderna i denna strategiska forskningsplan överensstämmer i stora delar med

https://www.epihealth.lu.se/sites/epihealth.lu.se/files/2021-05/epihealth_strategisk_plan_2020-2025_SVENSK_nytt.pdf - 2026-07-12

A transcription of the fifth episode of season two.   Nic: This is the fifth episode of the second season of our podcast Meridian, as so often is the case, we are recording in a shower room at Lund Observatory and it is April 1st today, crossing our local Meridian today we have a visitor from Uppsala University, Michael Way, a physical scientist who works at the Goddard Institute for Space Studies

https://www.astro.lu.se/meridian-s02e05 - 2026-07-11