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The aryl alkyl alcohol (AAA) fragrance ingredients are a diverse group of chemical structures with similar metabolic and toxicity profiles. The AAA fragrances demonstrate low acute and subchronic dermal and oral toxicity. No carcinogenicity in rats or mice was observed in 2-year chronic testing of benzyl alcohol or alpha-methylbenzyl alcohol: the latter did induce species and gender-specific renal
Climate change mitigation and energy security are partly interacting areas that both present future challenges. The extensive research underway within these areas is mainly conducted in separate research communities, although there are some integrative efforts. This paper examines the breadth and heterogeneity involved in treating energy security and climate change mitigation as a combined researc
The role of inflammation in atherosclerotic disease is well established, but the role of autoantibodies against modified apolipoprotein (apo) B-100 remains unclear. The metabolic syndrome is associated with a proinflammatory state, a predominance of small dense low-density lipoprotein (LDL) particles, and an increased risk for atherosclerotic diseases. Previous studies have shown specific autoanti
Recent research has brought into focus the function of switching between verb forms and types of clauses, here labelled ‘gram switching’, as a device for marking non-main clause linking in various types of Arabic and in Biblical Hebrew (Persson forthcoming a; Isaksson, Kammensjö, and Persson 2009; Isaksson 2011, 2013). The study presented here shows that a switch, either in verb form/morphology or
EU:s konkurrensrätt och Artikel 102 FEUF syftar till att förhindra snedvridningar av konkurrensen. Enligt ekonomisk teori så ökar en frimarknadsekonomi samhällsnyttan genom konkurrens. Denna slutsats kan motiveras av de två teoretiska modellerna perfekt konkurrens och dess motsats monopol, en total avsaknad av konkurrens. Ett viktigt undantag till detta antagande existerar i de fall där monopol ärEU competition law, and Article 102 TFEU, strives to prevent the distortion of competition. According to economic theory, a free market economy where resources are allocated through competition can generally be expected to increase the total utility of society. The theoretical models of perfect competition and its opposite monopoly, a total lack of competition, motivates this conclusion. An import
Traffic accidents are extremely rare, creating the need for surrogate methods for safety analysis that makes efficient use of the information provided by traffic conflicts, which also are limited in availability. The severity measure time-to-collision (TTC) in combination with extreme value theory have so far been one of the primary measures used to infer traffic safety levels, but it relies on un
The development of Mälaräng in the southwestern part of Stockholm aims to bridge the social and economic gap in between neighboring areas Mälarhöjden and Bredäng. Theories of the Just City by Susan Fainstein and the Lively City constructed by Jane Jacobs are applied to investigate the planning of Mälaräng regarding social, economic and physical environment-factors through the lens of justice and l
This thesis deals with the vital issue of empowerment in development work and development projects, a multimillion dollar enterprise which engages donors,governmental agencies and governments. More specifically the thesis deals with a development intervention in education as social policy in Uruguay, investigated as a case study. The methodological intention is to present the voices of the subject
This thesis examines how outnovation is enacted within design entrepreneurship, with fashion design entrepreneurship as the empirical context. It analyses how value formed through design practice may contribute to sustainable competitive advantage. Understood as an alternative innovation logic centred on authenticity, nostalgia, simplicity, and sustainability, outnovation offers a counterpoint to
Purpose: To study how LinkedIn can be used as a strategic brand-building tool across two dimensions: 1) for individual professionals and 2) for organizations. The study explores the relationship between brand identity and audience engagement, and how it can be leveraged in digital branding. Methodology: A qualitative case study across the two dimensions. We use secondary data and abductive reason
Epilepsy affects a significant portion of people worldwide and still requires alternative treatments due to resistance to anti-seizure medications. Gene therapy offers a promising alternative with several targets already established. Of these, glial cell line-derived neurotrophic factor (GDNF) and its receptor GFR⍺1 are well recognised for their roles in enhancing inhibitory signalling and support
Galectins are glycan-binding proteins that can reprogram the function of many cell types. They are involved in different positive and negative physiological functions in the human body including inflammation and autophagy. Thus, they have been suggested as therapeutic targets for tumour progression and they have been proposed as biomarkers for diagnosis. Galectins bind to the carbohydrates on the
Transylvania’s countryside, characterized by a mostly agrarian society with a rich multicultural heritage is being threatened by Romania’s tendencies of chaotic modernization and rapid urbanization. This research aims to find a viable solution for sustaining the cultural, natural, and social environment in rural Transylvania, by analysing the potential of tourism development. Integrated Rural Tour
Considering the looming threat of rising sea levels and the imminent flooding of many coastal cities by 2050, numerous initiatives are underway to strengthen these regions with various flood protection programs and barriers. However, there might be another solution than just building barriers around our cities. What if, rather than building next to the water, we envision a lifestyle where we inhab
This project is part of a larger effort to design bacterial sialic acid inhibitors based on sialic acid, Neu5Ac. The emergence of antimicrobial resistance is a major concern for the public health and causes a significant number of deaths globally each year. There is an urgent need to discover novel antibacterials to still be able to cure infections in the future. This project explores a strategy b
The planetary system around the naked-eye star v2 Lupi (HD 136352; TOI-2011) is composed of three exoplanets with masses of 4.7, 11.2, and 8.6 Earth masses (M⊕). The TESS and CHEOPS missions revealed that all three planets are transiting and have radii straddling the radius gap separating volatile-rich and volatile-poor super-earths. Only a partial transit of planet d had been covered so we re-obs
Inflammatory response induced by microglia plays a critical role in the demise of neuronal populations in neuroinflammatory diseases. Although the role of toll-like receptor 4 (TLR4) in microglia's inflammatory response is fully acknowledged, little is known about endogenous ligands that trigger TLR4 activation. Here, we report that galectin-3 (Gal3) released by microglia acts as an endogenous par
