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High blood pressure, or hypertension, is the leading single risk factor for the global burden of disease. Hypertension often coexists with several anthropometric and metabolic abnormalities, including abdominal obesity, dyslipidemia, and glucose intolerance—in combination referred to as metabolic (or cardiometabolic) syndrome. Indeed, hypertension occurs in a large proportion of those with metabol
Thioredoxin and thioredoxin reductase can regulate cell metabolism through redox regulation of disulfide bridges or through removal of H(2)O(2). These two enzymatic functions are combined in NADPH-dependent thioredoxin reductase C (NTRC), which contains an N-terminal thioredoxin reductase domain fused with a C-terminal thioredoxin domain. Rice NTRC exists in different oligomeric states, depending
The tenth-century Byzantine hagiographical Life of Theoktiste, written by Niketas Magistros, has been read in various ways, not in the least intertextually and as the life of a non-existing saint. The present article further investigates the motives of the author, the social and cultural vision, as well as generic notions, embedded in the text, and offers a new date of composition for the Life, vi
Objectives: High quality nutrition and medical nutrition therapy in long-term care (LTC) settings are essential to overcome malnutrition and ensure a better quality of life. Heterogenous and often insufficient regulations contribute to a disparity in nutritional practices across Europe. The aim of the study was to gather information on nutrition-related regulations and practices, as well as establ
Introduction: Occupational balance is an important concept in occupational therapy. However, no validated Occupational balance assessments currently exist in Lithuania. This study aimed to examine the psychometric properties of the Lithuanian version of the Occupational Balance Questionnaire 11 (OBQ11-LT). Method: A total of 127 healthy adults completed the OBQ11-LT to evaluate construct validity.
This paper examines the distributive effects of personal income taxation in Sweden, the United Kingdom, and the United States during the first half of the twentieth century. We estimate the evolution of marginal and average effective tax rates across the income distribution and calculate the corresponding indices of progressivity and redistribution. Our results show that redistribution through inc
Infections are a common reason for hospitalization, and when an infection is accompanied by organ failure, the patient is considered to have sepsis. The most severely ill sepsis patients are treated in the Intensive Care Unit (ICU). Identifying sepsis at ICU admission is, however, challenging, since most ICU patients present with organ failure and there is no gold standard for infection diagnosis.
Intracellular deposits of neurofibrillary tau tangles and extracellular Aβ plaques are closely associated with Alzheimer’s disease. The mapping of thermodynamic parameters, including solubility limits, indicates when a protein forms amyloid fibrils or remains in solution. This reveals the direction of change of the system and may help in understanding drift and steady states in living systems. Her
The clustering of certain proteins into oligomers and fibrils, known as amyloids, underlies the pathology of diseases such as Alzheimer’s disease, Parkinson’s disease, and type 2 diabetes. These processes are counteracted by the cellular protein quality control system, which includes molecular chaperones that interact with disease-associated proteins. One such chaperone is DNAJB6b, which has gaine
This paper presents a novel application which implements a way of adding sound breadcrumbs to the environment. We report results from initial user tests which suggest that this type of design could be useful for a wide range of mobile location based applications.
This doctoral thesis investigates changes in the volume and character of Swedish manufacturing sector innovation output between 1970 and 2007, a time span composed of both extended periods of relative prosperity and decline. More specifically, it examines whether changes in the number of innovations, the character of the innovating firms, and the distribution of innovations across industries are g
