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Objective The complex genetic aetiology underlying irritable bowel syndrome (IBS) needs to be assessed in large-scale genetic studies. Two independent IBS cohorts were genotyped to assess whether genetic variability in immune, neuronal and barrier integrity genes is associated with IBS. Design 384 single nucleotide polymorphisms (SNPs) covering 270 genes were genotyped in an exploratory cohort (93

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New strategies are needed for breast cancer treatment and one initial step is to test new chemotherapeutic drugs in breast cancer cell lines, to choose candidates for further studies towards clinical use.

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Sulfonated polysulfone (sPSU) membranes were analysed by nuclear magnetic resonance (NMR) cryoporometry, conventional gravimetric water uptake measurements as well as by differential scanning calorimetry (DSC). NMR cryoporometry is based on the relation between the pore size and the melting point depression of the pore-filling liquid, i.e. water in fuel cell membranes; thus providing a relation be

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This thesis examines the nature and purpose of the Greek sciences ἀριθμητική, λογιστική and γεωμετρία in the texts of Plato. The statements of some other ancient authors are also mentioned, and the relevant modern research is consulted. ἀριθμός is at any instance, as Klein has already noted, ‘a definite number of definite objects’. In Plato’s philosophical ἀριθμητική, ἀριθμός seems to always consi

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The phylogenetic relationships between the five dioecious species in Silene section Melandrium (Caryophyllaceae) and their putative hermaphrodite relatives are investigated based on an extensive geographic and taxonomic sample, using DNA sequence data from the chloroplast genome and the nuclear ribosomal ITS region. The hermaphrodite S. noctiflora (the type species of section Elisanthe) is distant

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Irrigation water is an important vehicle for dissemination of human pathogens to plants. As contamination in an early stage of the production chain cannot necessarily be counteracted later, cultural measures to reduce the contamination risk need to be adopted during primary production. In a two-factorial greenhouse experiment, we studied the impact of inoculum density and the interval between irri

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Urban trees are uniquely valuable in towns and cities for the ecosystem services they provide their citizens and can as such be considered a potent source of public goods and positive externalities - even when these trees are found on private properties. The importance of urban trees will only grow as events of severe heat and extreme rainfall become more and more frequent and the urgency to reduc

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Efficient recovery and utilization of valuable components from industrial food side streams is a main driver towards a circular economy. Among different available purification techniques, adsorption can effectively recover these components. However, the conventional batch mode of operation can limit its applicability in food processes due to limited efficiency. This work compares conventional batc

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The city of Milan stands today as a prominent model of sustainable urban development. Yet, beneath its allure lies a paradox: the quest for 'green' and 'smart' development has exacerbated privatization and fueled debates on green gentrification, social equity, and urban accessibility. This research explores the emerging impacts of large-scale green urbanization intervention in the

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Boronate-containing thin polyacrylamide gels (B-Gel), polymer brushes (B-Brush) and chemisorbed organosilane layers (B-COSL) were prepared on the surface of glass slides and studied as substrates for carbohydrate-mediated cell adhesion. B-COSL- and B-Brush-modified glass samples exhibited multiple submicron structures densely and irregularly distributed on the glass surface, as found by scanning e

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Denna uppsats behandlar det svenska naturskyddets rättsutveckling från de första naturskyddslagarnas tillkomst i början av 1900-talet fram till idag. Uppsatsens syfte är att undersöka naturskyddslagstiftningens utveckling vad gäller innehåll, motiv och bakomliggande miljöetisk natursyn. Undersökningen påvisar en rättsutveckling där lagstiftningen fått en ökad omfattning och högre ambitioner. Från

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We present a study of the inclusive charged-particle transverse momentum (pT) spectra as a function of charged-particle multiplicity density at mid-pseudorapidity, d Nch/ d η, in pp collisions at s=5.02 and 13 TeV covering the kinematic range | η| < 0.8 and 0.15 < pT< 20 GeV/c. The results are presented for events with at least one charged particle in | η| < 1 (INEL>0). The pT spectra are reported

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Background: Certain immunoglobulins (Ig) are proposed to have protective functions in atherosclerosis.Objectives: We tested whether serum levels of IgG and IgM autoantibodies against malondialdehyde low density lipoprotein (MDA-LDL) are associated with clinical coronary heart disease (CHD) and unfavorable plaque characteristics.Methods: NORDIL was a prospective study investigating adverse cardiova

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This paper presents a novel method to access lived religion and magical practices of a Medieval congregation via sermons combined with material culture. Previously, scholars have dismissed sermons as having low ‘truth value’ due to the copying inherent in the genre. In this paper, I first examine how one Danish sermon was adapted from a German model to fit a local context. This adaptation reveals

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BACKGROUND: Brevican and neurocan are central nervous system-specific extracellular matrix proteoglycans. They are degraded by extracellular enzymes, such as metalloproteinases. However, their degradation profile is largely unexplored in cerebrospinal fluid (CSF).OBJECTIVE: The study aim was to quantify proteolytic peptides derived from brevican and neurocan in human CSF of patients with Alzheimer