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A large proportion of people with type 2 diabetes (T2D) remain uncontrolled on basal insulin. Yet, there is limited understanding of how people with uncontrolled type 2 diabetes (PWUD) perceive control and insulin intensification and whether their perceptions differ from those of physicians. The purpose of the study was to investigate perceptions of control and views on insulin intensification amo
The U.N. Convention on the Rights of Persons with Disabilities (CRPD) may require the abolition of the insanity defense and similar “special defenses” in criminal law. Proponents argue that abolishing the defense would advance efforts to fully recognize the legal capacity of persons with disabilities on an equal basis with others; detractors suggest it would compound the substantive inequality of
Based on fieldwork in Syria, Turkey, Germany and the Netherlands and a unique personal 20-year old ethnographic film archive, this paper traces life histories of Syrian refugees and documents their experiences encountering people, institutions and customs of German and Dutch welfare states.
Lung cancer and chronic lung diseases impose major disease burdens worldwide and are caused by inhaled noxious agents including tobacco smoke. The cellular origins of environmental-induced lung tumors and of the dysfunctional airway and alveolar epithelial turnover observed with chronic lung diseases are unknown. To address this, we combined mouse models of genetic labeling and ablation of airway
Our previous studies have shown that spontaneously arising immunocytomas in the LOU/Ws1 strain of rats contain a t(6;7) chromosomal translocation in all seven tumors studied (F. M. Babonits, J. Spira, G. Klein, and H. Bazin, Int. J. Cancer 29:431-437, 1982). We have also shown that the c-myc is located on chromosome 7 (J. Sümegi, J. Spira, H. Bazin, J. Szpirer, G. Levan, and G. Klein, Nature (Lond
Conflicts of interests between males and females over reproduction is a universal feature of sexually reproducing organisms and has driven the evolution of intersexual mimicry, mating behaviours and reproductive polymorphisms. Here, we show how temperature drives pre-reproductive selection in a female colour polymorphic insect that is subject to strong sexual conflict. These species have three fem
This article builds on recent works on witnessing, socially engaged documentary filmmaking and studies on the role of new digital technologies for witnessing trauma, recording memories and enabling activism. In a devastating earthquake in Sichuan province on 12 May 2008, almost 90,000 people, at least 5000 of them being children, died. Parents and bystanders provided the first footage of the earth
The last Catholic archbishop of Sweden to hold residence in his see at Uppsala, Johannes Magnus (1488-1544), was the author of a major work about Swedish history: the Historia de omnibus Gothorum Sueonumque regibus. Johannes Magnus left Sweden in 1526, spent the rest of his life away from his home country and eventually died in Rome, where his work was published posthumously in 1554. One reason fo
Objectives. The arachidonate 5-lipoxygenase activating protein (ALOX5AP) regulates synthesis of leukotrienes (LTs), which are important mediators of inflammation and connective tissue remodelling. The aim of this study was to evaluate if single nucleotide polymorphisms (SNPs) of ALOX5AP confer risk of SSc and/ or SSc-related organ involvement. Methods. Seven SNPs of ALOX5AP (rs17222814, rs17216473
Living labs as a research approach have been said to hold many promises regarding the evaluation of state-of-the art technologies in real-world contexts, for instance by allowing close cooperation with various stakeholders. At the same time, a living lab approach is connected with substantial complexity and increased risk. This paper elaborates on a conducted living lab with the objective to explo
This statement provides a concise list of diagnostic terms for ECG interpretation that can be shared by students, teachers, and readers of electrocardiography. This effort was motivated by the existence of multiple automated diagnostic code sets containing imprecise and overlapping terms. An intended outcome of this statement list is greater uniformity of ECG diagnosis and a resultant improvement
Background: Elderly individuals with chronic conditions or acute illnesses are major drivers of hospitalization, with frail patients frequently utilizing emergency department (ED) services. To ease this burden, many countries offer home-based medical services. In Region Halland, Sweden, a mobile team intervention in municipal home care (MHC) was introduced to support frail elderly patients. This s
The cellular polyamines spermine, spermidine, and their metabolic precursor putrescine, have long been associated with cell-growth, tumor-related gene regulations, and Alzheimer's disease. Here, we show by in vitro spectroscopy and AFM imaging, that these molecules promote aggregation of amyloid-beta (Aβ) peptides into fibrils and modulate the aggregation pathways. NMR measurements showed that the
Road traffic accidents cause nearly 1.3 million deaths and around 50 million injuries each year globally. Most organisations generate travel and transport, and influence thereby traffic safety. In Sweden, 47 percent of fatal accidents in road traffic are work-related, and 36 percent are linked to a procured transport service. Effective approaches to managing traffic safety in organisations have no
Background: The globally dominant treatment with curative intent for locally advanced esophageal squamous cell carcinoma (ESCC) is neoadjuvant chemoradiotherapy (nCRT) with subsequent esophagectomy. This multimodal treatment leads to around 60% overall 5-year survival, yet with impaired post-surgical quality of life. Observational studies indicate that curatively intended chemoradiotherapy, so-cal
Enligt forskare och praktiker innebär klimatförändringarna särskilda utmaningar för freden. För att förstå vilka dessa utmaningar är och hur man ska hantera dem måste man ta hänsyn till kön, eftersom både erfarenheter av och processer för fred, samt drivkrafter bakom klimatförändringar är könsbundna. Exempelvis kan kvinnor och män uppleva förhållandena efter en vapenvila på olika sätt, eller så kaScholars and practitioners argue that climate change poses particular challenges for peace. In order to understand what these challenges are and how to tackle them necessitates attention to gender, since experiences and processes of peace are gendered, as are experiences and drivers of climate change. For instance, women and men may experience conditions after a ceasefire differently, or climate h
We all want to develop impactful and valuable theories, but what do we mean by ‘theory’? In this piece, we reply to the four readers’ comments on a recent paper in which we propose a theory typology that, in comparison to existing literature, offers a considerably broader, more pluralistic and, at the same time, more precise definition of the meaning(s) of ‘theory’ within academia. In their commen
Following vascular injury, basement membrane (BM) components of the blood vessels are exposed to circulating cells and may contribute to hemostasis and/or thrombosis. Laminins 8 (LN-8) (alpha4beta1gamma1) and 10 (LN-10) (alpha5beta1gamma1) are major laminin isoforms of the endothelial BM, and LN-8 is also secreted by activated platelets. In the present study, we demonstrate synthesis of alpha5-lam
