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Alzheimer's Disease (AD) is the most prevalent form of dementia worldwide, yet the development of therapeutics has been hampered by the absence of suitable biomarkers to diagnose the disease in its early stages prior to the formation of amyloid plaques and the occurrence of irreversible neuronal damage. Since oligomeric A beta species have been implicated in the pathophysiology of AD, we reasoned
A series of azaflavone derivatives and analogues were prepared and evaluated for their affinity to the benzodiazepine binding site of the GABA(A) receptor, and compared to their flavone counterparts. Three of the compounds, the azaflavones 9 and 12 as well as the new flavone 13, were also assayed on GABA(A) receptor subtypes (alpha(1)beta(3)gamma(2s), alpha(2)beta(3)gamma(2s), alpha(4)beta(3)gamma
The literature on the relationship between the size of government and economic growth is full of seemingly contradictory findings. This conflict is largely explained by variations in definitions and the countries studied. An alternative approach – of limiting the focus to studies of the relationship in rich countries, measuring government size as total taxes or total expenditure relative to GDP an
The thesis shows how different aspects of sustainable development have been handled or not handled in the third generation infrastructure development in Sweden. The difference between the design of the 3G development - emphasizing competition, growth and regional access, based on a strong technological optimism - and the implementation, as the roll out struck the landscape, including the non-handl
The aim of this thesis is to explore the interrelation of employer branding and employee engagement in the context of corporate restructuring and organizational change. Our research follows an interpretative and abductive approach. We have conducted a qualitative case study with Ingka Centres as our case company. This thesis contributes to the literature on employer branding and employee engagemen
The intake of anthocyanin rich-foods, such as bilberries has been associated with a reduced risk of developing cardiovascular-related diseases. Similarly, the cardiovascular benefits of oat consumption are well known and are mainly due to its cholesterol-lowering and hypoglycemic effects. A randomized double-blinding clinical trial has been designed to investigate the cardiovascular beneficial eff
Rätten till “remedial secession” är en av de mest kontroversiella frågorna i internationell rätt. Ett större antal juridiska forskare har hävdat att en sådan rätt finns, men stater har visat sig motvilliga för att stödja en sådan rätt. Efter Kosovos självständighetsförklaring från Serbien 2008 sattes frågan om ”remedial secession” på spetsen igen. Trots att ICJ konstaterade att deras självständighThe right to remedial secession is one of the most divisive issues in interna-tional law. An increasing number of legal scholars have argued that such a right exists, but State practise has shown little support for such a right. Fol-lowing Kosovo’s unilateral declaration of independence from Serbia in 2008, the legality of remedial secession was put at the centre of attention once again. While the
Investing based on environmental, social, and governmental (ESG) criteria has grown rapidly in recent years. The trend has been driven by both an increased interest in sustainability, and the fact that ESG related corporate events have been shown to influence stock prices. In tandem with this development, a number of companies has pioneered methods to quantify a firm’s ESG performance. One of thes
Purpose: This research analyzes the phenomenon of brand revitalization and brand nostalgia in order to understand their influence on brand image. Design/Methodology: This study is based on a qualitative approach. It involves two case studies, both of which are studied through secondary data and focus groups. Findings: This research found that nostalgia can have positive or negative effects when th
Objectives. The EGFR is expressed in malignant ovarian tumor tissue, and tissue content of EGFR has been directly associated with poor prognosis in patients with ovarian cancer. The uPA system plays a role in pericellular proteolysis, cell migration, invasion, and is over-expressed in ovarian cancer. This study explored the effects of EGF on uPAR expression in the ovarian cancer cell line OVCAR-3.
This article shows how participation on national, regional and local levels is regulated in the infrastructure of the third generation of mobile telephony, 3G, in Sweden. This regulated participation, the “law in books”, is compared to participation in practice, the “law in action” perspective in the sense of the outcome and functionality of these regulations. This includes the identification of i
The open and closed forms of ozone and the path connecting them through a transition state, in C-2v symmetry, are explored using the multi-state, multi-configurational second order perturbative method, MS-CASPT2. It is demonstrated that, by using an ANO-L triple-zeta basis set, it is possible to set up an active space able to describe the otherwise troublesome transition state region. Both a conic
OBJECTIVE-Using the genome-wide association approach, we recently identified the glucokinase regulatory protein gene (GCKR, rs780094) region as a novel quantitative trait locus for plasma triglyceride concentration in Europeans. Here, we sought to study the association of GCKR variants with metabolic phenotypes, including measures of glucose homeostasis, to evaluate the GCYR locus in samples of no
Background: Diagnosis of Mycoplasma pneumoniae (MP) infection is traditionally based on serology, which may require more than two weeks for diagnostic antibodies to develop. PCR-based methods offer earlier diagnosis. During a community outbreak of MP infection, we compared seminested and real-time PCR of oropharyngeal swabs with serology for diagnosis of MP infection at different time points after
Phosphoryl transfer reactions can proceed through several plausible mechanisms, and the potential for both solvent and substrate-assisted pathways (involving proton transfer to the phosphoryl oxygens) complicates both experimental and computational interpretations. To avoid this problem, we have used electronic structure calculations to probe the mechanisms of the reactions of pyridinio-N-phosphon
RATIONALE: Preterm infants diagnosed with bronchopulmonary dysplasia (BPD) are thought to have fewer and larger alveoli than their term peers, but it is unclear to what degree this persists later in life.OBJECTIVES: To investigate to what degree the distal airspaces are enlarged in adolescents born preterm and to evaluate the new Airspace Dimension Assessment (AiDA) method in investigating this gr
The paper shows, based on a case study of the production of a strategic plan at a fairly traditional university, the problems and potential meaninglessness of working with strategic plans in this type of setting, characterized by strong professional norms. Senior people involved in the strategy work raise strong doubts over, and distancing from, the process and outcome. Possible meanings of the st
Purpose: To investigate if hip and knee alignment assessed 2 years after anterior cruciate ligament (ACL) injury is associated with compartment-specific radiographic knee osteoarthritis (OA) 3 years later. Methods: An exploratory analysis was conducted in the knee ACL, nonsurgical versus surgical treatment (KANON) trial (ISRCTN84752559); 115 subjects with acute ACL injury were assessed at the 2-ye
Being deeply embedded in the mythological framework of old-school Christian angelology, the theodicy presented in this article outlines a thoroughgoing and unexpectedly simple solution to the problem of evil. Unlike other Satan-oriented theodicies, whose central idea is that natural evil is reducible to moral evil by taking the malevolent actions of demons into consideration, it accounts for both
