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Factor I (FI) is the major complement inhibitor that degrades activated complement components C3b and C4b in the presence of specific cofactors. Complete FI deficiency results in secondary complement deficiency due to uncontrolled spontaneous alternative pathway activation. In this study we describe two unrelated patients with complete FI deficiency and undetectable alternative complement pathway
Static light scattering (SLS) combined with structure-based Monte Carlo (MC) simulations provide new insights into mechanisms behind anisotropic, attractive protein interactions. A nonmonotonic behavior of the osmotic second virial coefficient as a function of ionic strength is here shown to originate from a few charged amino acids forming an electrostatic attractive patch, highly directional and
Biocompatible molecules that undergo self-assembly are of high importance in biological and medical applications of nanoscience. Peptides and bile acids are among the most investigated due to their ability to self-organize into many different, often stimuli-sensitive, supramolecular structures. With the aim of preparing molecules mixing the aggregation properties of bile acid and amino acid-based
Objective: By retarding fat digestion, thylakoids, the internal photosynthetic membrane system of green plants, promote the release of satiety hormones. This study examined the effect of consuming a single dose of concentrated extract of thylakoids from spinach on satiety, food intake, lipids, and glucose compared to a placebo. Design: Sixty overweight and obese individuals enrolled in a double-bl
In neurophysiology, investigating brain connectivity within and between different brain structures is of fundamental importance for understanding nervous system function and its relation to behavior. Yet, parallel recordings in multiple brain structures is highly challenging, especially in rodents, which are most commonly employed in neurophysiological research but rather small in size. In this st
Detta är en kvalitativ studie som avhandlar ämnesintegration och hur det kan tillämpas av lärare i musik och engelska. Den ger även en inblick i hur lärare jobbar med det centrala innehållet i musik, med specifikt fokus på den del som kallas musikens sammanhang och funktion. Fyra lärare med ämneskombinationen musik och engelska har intervjuats. Jag har även gjort litteraturstudier för att få en dj
Ovarian masses are common and a good pre-surgical assessment of their nature is important for adequate treatment. Bayesian Multi-Layer Perceptrons (MLPs) using the evidence procedure were used to predict whether tumors are malignant or not. Automatic Relevance Determination (ARD) is used to select the most relevant of the 40+ available variables. Cross-validation is used to select an optimal combi
In this thesis civil religion in the Czech Republic is studied throught the way it is expressed in the speeches of president Václav Havel. Earlier studies on civil religion have shown how civil religiion can be a latent phenomenon that is activated in times of societal change and crisis. In Havel's speeches, this is expressed by the emphasis put on democratic values, such as basic human rights, an
Abstract Aid-tying is considered costly and ineffective to recipient countries and it is estimated that costs increases by as much as 30 per cent due to its practice. The Paris Declaration on enhanced aid effectiveness suggested an end to tied aid. The purpose of this paper is to give a review of the development of aid-tying in the European countries in the last thirty years. It will also look at
Lasers and masers have numerous uses in today’s society. Improving our understanding of the underlying physics and its application is thus of great importance. In this paper, the physics of a three-level maser when treated as a heat-engine was investigated: certain levels were coupled to thermal-reservoirs, effectively allowing for pumping without an external bias. The thermodynamical treatment fo
Background: Tinnitus sufferers commonly report concentration difficulties. Despite several previous studies investigating this, the underlying cause and the role of hearing status remains unclear. Purpose: To investigate whether there are any differences between normal hearing individuals with and without tinnitus in terms of working memory capacity, and whether working memory capacity correlates
We report that overexpression of the m6A-demethylase alkB homolog 5 RNA demethylase (ALKBH5) promoted production of intron retention on the human papillomavirus type 16 (HPV16) E6 mRNAs thereby promoting E6 mRNA production. ALKBH5 also altered alternative splicing of the late L1 mRNA by an exon skipping mechanism. Knock-down of ALKBH5 had the opposite effect on splicing of these HPV16 mRNAs. Overe
Terrorism comes in various forms, clear and sometimes ambiguous, by terrorist cells and sometimes by state players. Nerve agent poisoning represents one of the notorious applications of chemistry in the world. Nerve agents have historically instigated major casualties in various parts, heavily impacting lives of civilians by causing debilitating neurological and psychiatric injuries. Nerve agents
Western Sierra Morena constitutes a singular link between the Roman provinces of Baetica and Lusitania, in terms of its physiography and historical development. This region, characterised by its rugged topography, forests, and abundant mineral resources, was decisively transformed after the Roman conquest. Such transformations are visible in the characteristics of the archaeological record and in
Disability scholars have recently proposed that republican theory is relevant to think about justice in relation to disability. Following in their footsteps, this article submits that the republican conception of freedom as non-domination provides a fresh angle to legitimise disability rights in terms of justice and prevent their interpretation as charity or privileges. This proposition takes its
B cells produce antibodies, key effector molecules in health and disease. They mature their properties, including their affinity for antigen, through hypermutation events; processes that involve, e.g., base substitution, codon insertion and deletion, often in association with an isotype switch. Investigations of antibody evolution define modes whereby particular antibody responses are able to form
