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Diastolic Filling in Patients After Heart Transplantation Is Impaired Due to an Altered Geometrical Relationship Between the Left Atrium and Ventricle

BackgroundThe geometrical relationship between atrial and ventricular short‐axis cross‐sectional area determines the hydraulic forces acting on intracardiac blood. This is important for diastolic filling. In patients undergoing heart transplantation (HTx), the left atrium is often enlarged as a result of the standard surgical technique. We hypothesized that diastolic filling in HTx patients is aff

Mammalian cell display with automated oligo design and library assembly allows for rapid residue level conformational epitope mapping

Precise epitope determination of therapeutic antibodies is of great value as it allows for further comprehension of mechanism of action, therapeutic responsiveness prediction, avoidance of unwanted cross reactivity, and vaccine design. The golden standard for discontinuous epitope determination is the laborious X-ray crystallography method. Here, we present a combinatorial method for rapid mapping

EDGE : the shape of dark matter haloes in the faintest galaxies

Collisionless dark matter only (DMO) structure formation simulations predict that dark matter (DM) haloes are prolate in their centres and triaxial towards their outskirts. The addition of gas condensation transforms the central DM shape to be rounder and more oblate. It is not clear, however, whether such shape transformations occur in 'ultra-faint' dwarfs, which have extremely low baryon fractio

Unveiling the gravitationally unstable disc of a massive star-forming galaxy using NOEMA and MUSE

Using new high-resolution data of CO (2-1), H and H obtained with the Northern Extended Millimeter Array (NOEMA) and the Multi-Unit Spectroscopic Explorer (MUSE) at the Very Large Telescope, we have performed a Toomre Q disc stability analysis and studied star formation, gas depletion times and other environmental parameters on sub-kpc scales within the z ∼0 galaxy SDSS J125013.84+073444.5 (LARS 8

A Companion to Birgitta of Sweden : And Her Legacy in the Later Middle Ages

St. Birgitta of Sweden (d. 1373) is one of the most celebrated female visionaries and authors of the Middle Ages and a central figure in the history of late-medieval religion. An aristocratic widow, Birgitta left her native country in 1349 and settled in Rome, where she established herself as an outspoken critic of the Avignon Papacy and an advocate of spiritual and ecclesiastical reform. Birgitta

Hydro-meteorological droughts across the Baltic Region : The role of the accumulation periods

Based on the physical and geographical conditions, the Baltic Region is categorised as a humid climate zone. This means that, there is usually more precipitation than evaporation throughout the year, suggesting that droughts should not occur frequently in this region. Despite the humid climate in the region, the study focused on assessing the spatio-temporal patterns of droughts. The drought event

"I världen, men icke av världen" : Konstruktionen av kristen manlighet i Skånes Missionssällskap ca 1939-1945

The aim of this study is to analyze the construction of "Christian masculinity" during the modern era. This is made in opposition to earlier research that has claimed that masculinity could not be constructed religiously, that is, without at the same time being constructed as effeminate or anti-masculine. Using a wide variety of theoretical concepts - such as discourse analysis, class,

Lämpliga skogsbruksfastigheter - Prövningen av 3 kap. 5 och 7§§ fastighetsbildningslagen (1970:988) i praktiken

Detta arbete avser att kartlägga hur prövningen av 3 kap. 5 och 7 §§ fastighetsbildningslagen (1970:988) (FBL 3:5 och 3:7) har skett i lantmäteriförrättningar från 2004 fram till våren 2016, samt att kartlägga eventuella skillnader över landet. Slutsatserna från dessa frågeställningar väntas ge ett svar på huruvida prövningen eller lagstiftningen är i behov av förändring. En litteraturstudie har gThe Swedish Real Property Formation Act (1970:988), 3rd Chapter, 5th and 7th §§ (FBL 3:5 and 3:7) regulates protection of forested real property. The trial in practice have been investigated through an analysis of records of cadastral procedures performed in Sweden from 2004 to spring 2016. The most important conclusion of the investigation is that the trial is heterogeneous over the country. It h

Beyond Mean-Field Description of Bose-Einstein Condensate

This thesis work is on the theoretical description of dilute Bose-Einstein condensates (BEC) that are non-uniform, meaning that more than one single-particle state is occupied. This phenomenon is usually called quantum depletion. A common model for the ground state of a dilute and weakly interacting BEC is the mean-field (MF) approximation leading to the Gross-Pitaevskii (GP) equation. However, fo

Generalstrejk, sabotage och terror: anarkosyndikalisternas strategi före första världskriget i D. Novomirskijs och A. Jensens skrifter

This essay investigates the revolutionary strategy of the anarcho-syndicalists in Russia and Sweden before the World War I. The purpose of the research is to gain new knowledge about the relationship between the goal and the method from the point of view of the ideology of anarchosyndicalism. The study explores how the same ideology shaped strategy in two different national contexts. Publications

Back to Basics: How Trump’s Zero Tolerance Policy evidenced the Inefficiency of the Human Rights Framework, and the Urgency to re-center Human Dignity

In 2018, images of migrant children held in cages and sleeping on concrete floors while being held in immigration detention in the United States shocked the world. Within the framework of the zero tolerance policy on immigration mandated by President Trump, thousands of families have been separated at the border. The trauma borne out of these separations was purposefully capitalized upon to serve

The Impact of Country-Specific Contextual Factors on the Outcome of Section 1502 of the Dodd-Frank Act Regulating Conflict Minerals in the Democratic Republic of Congo

The conflict mineral crisis has been ongoing in the DRC for nearly two decades, with armed groups and increased military presence have played on the tin, tantalum, tungsten and gold to fund a brutal war across the eastern region of the country. Recent international efforts to tackle such illicit trade in conflict minerals has focused on requiring relevant stakeholders involved in the mineral sourc

Recasting the Dublin Regulation : an analysis of the impact of the M.S.S. and N.S./M.E. judgments on the recast of the Dublin Regulation

Syftet med Dublinförordningen är att se till att asylansökningar behandlas av endast en medlemsstat, för att undvika fenomenen “asylsum shopping” och “refugees in orbit”. Förordningen består av en hierarki av kriterier för att fastställa vilken stat som är ansvarig, men detta har också lett till principen om ömsesidigt förtroende mellan medlemsstaterna, där alla stater förutsätts ha samma nivå av The purpose of the Dublin Regulation is to ensure that applications for asylum will be considered by one Member State, avoiding the phenomena of “asylum shopping” and “refugees in orbit”. The Regulation consists of a hierarchy of criteria for determining the responsible state, however, this has also resulted in the principle of Mutual Trust between Member States, where all states are presumed to h

Ekonomiskt våld – okänt, outtalat, oviktigt? – Synen på ekonomiskt våld i samband med straffrättslig reglering av stöld, skadegörelse och grov kvinnofridskränkning

Termen ”ekonomiskt våld” är för många ett relativt okänt begrepp, vilket bara under de senaste åren har börjat leta sig in i media och den allmänna samhällsdebatten. Bland forskare betraktas det ekonomiska våldet som mycket allvarligt och framför allt som en stor riskfaktor för att våldsutsatta kvinnor ska stanna i en våldsam relation. I svensk rätt finns inget straffbud som uttryckligen tar siktThe term “economic violence” is a concept that is relatively unfamiliar to many, which only in recent years has begun to find its way into the media and the general social debate. Many researchers regard economic violence as a very serious issue and, above all, as a major risk that may cause women that are victims of domestic violence to stay in a violent relationship. In Swedish law, there are n

Aggregation potency and proinflammatory effects of SARS-CoV-2 proteins

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is primarily known as a respiratory disease. The continued study of the disease has shown that long-term COVID-19 symptoms include persisting effects of the virus on the brain when the infection is over, possibly even leading to neurodegeneration. However, the exact mechanisms of

Sex-Specific Cardiovascular Consequences of Long-Term High-Salt Diet in Mice

BACKGROUND: Excessive dietary salt intake is associated with elevated blood pressure and damage to organs including the heart, vasculature, and kidneys. Women are more prone to salt-sensitive hypertension, yet preclinical studies often focus on men.METHODS: To examine sex-specific responses to chronic salt loading, male and female C57Bl6/J mice were fed a high-salt diet (HSD; 8% NaCl) from 7 to 14

Speaker’s comfort and vocal effort in different room acoustic conditions : A controlled field experiment in a university lecture room

Speaking in poor acoustic conditions constitutes a risk factor for voice disorders. This study investigated how speaker’s comfort and vocal effort were affected during short speech tasks in four different room acoustic configurations. Voice recordings of the speech tasks and self-evaluations of the speaker’s comfort were collected from 15 participants in four room acoustic configurations as part o

Physical examinations and whole-body imaging versus physical examinations alone during follow-up after radical surgery of stage IIB–C and III cutaneous malignant melanoma (TRIM) : an interim analysis of a multicentre, randomised, phase 3 trial in Sweden

Background In several countries, whole-body imaging has been introduced in the routine follow-up of individuals with high-risk cutaneous malignant melanoma after surgery. However, there is scarce evidence that earlier detection of recurrent disease by regular scanning improves survival. In this interim analysis, we investigated whether imaging in the follow-up programme for high-risk cutaneous mal

Postnatal development in the cold render bird mitochondria more susceptible to heat stress

Research on birds suggests that extreme weather events during development may have long-lasting consequences on form and function. The underlying cellular mechanisms mediating such phenotypic effects are poorly studied. We raised Japanese quail in warm (30°C) or cold (10°C) temperatures from hatching until adulthood and then measured mitochondrial metabolism in intact blood cells at representative