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BACKGROUND: Group 5 allergens, such as Phl p 5 of timothy grass, are major contributors to grass pollen allergy. Antibody 212597 specific for this allergen was recently isolated by single cell sequencing of bone marrow B cells of a grass pollen-allergic subject. This antibody, although subjected only to a low level of hypermutation resulting in six amino acid substitution across the heavy and ligh

Haro 11 is a metal-poor, starburst galaxy believed to be the result of an ongoing merger, which is shaping the properties of the galaxy. In this study, we carry out a large suite of numerical simulations of a merger between two disc galaxies, to study possible origins of Haro 11 and understand under which conditions various features of the galaxy are formed. By varying galaxy parameters describing

The European Resuscitation Council (ERC) and the European Society of Intensive Care Medicine (ESICM) have collaborated to produce these post-resuscitation care guidelines for adults, which are based on the International Consensus on Cardiopulmonary Resuscitation Science with Treatment Recommendations (CoSTR) pubished by the International Liaison Committee on Resuscitation (ILCOR). The topics cover

Aim: We examined the association of exposure to a pesticide mixture with respiratory and allergic outcomes among farmworkers from Costa Rica. Methods: We conducted a cross-sectional study of 299 farmworkers between May and August 2016. We collected information on sociodemographic factors, pesticide use, and the presence of respiratory and allergic symptoms during the last 12 months via questionnai

Autoimmune diseases are disorders where the immune system reacts against self-antigens to cause disease. Autoimmune disorders occur in about 5-7% of the population, although many individuals have no symptoms. In all, there are more than 70 different disorders, most of which are uncommon, apart from rheumatoid disease and autoimmune thyroiditis. Autoimmune diseases are clinical syndromes mediated b

Diagnosing sepsis in critical care remains a challenge due to the lack of gold-standard diagnostics. Calprotectin (S100A8/A9) has been proposed as a diagnostic marker to identify sepsis in critically ill patients. This study evaluated the diagnostic performance of calprotectin and C-reactive protein (CRP) to distinguish between sepsis and non-sepsis on intensive care unit (ICU) admission. Admissio

Inflammatory responses to acute stimuli are proposed to regulate sleep, but the relationship between chronic inflammation and habitual sleep duration is elusive. Here, we study this relation using genetically predicted level of chronic inflammation, indexed by CRP and IL6 signaling, and self-reported sleep duration. By Mendelian randomization analysis, we show that elevated CRP level within <10 mg

Abstract in UndeterminedIntestinal epithelial cells (IECs) play a key role in Crohn's disease, a chronic inflammatory bowel disease which requires invasive examinations to be diagnosed. The comparison of the cellular protein expression profiles of Crohn's disease patients and healthy subjects is fundamental for the identification of proteins clinically relevant as new biomarkers or as drug targets

BACKGROUND. Recently, the gene for cysteine-rich secretory protein 3 (CRISP-3) was reported to be highly upregulated in prostate cancer (PCa) compared to benign prostatic tissue. The current aims were to investigate diagnostic use of tissue expression and immunodetection in serum of CRISP-3 for detection or monitoring of PCa. METHODS. Radical prostatectomy specimens and tissue microarrays from tra

Tapasin (Tpn) is an ER chaperone that is uniquely dedicated to MHC-I biosynthesis. It binds MHC-I molecules, integrates them into peptide-loading complexes, and exerts quality control of the bound peptides; only when an "optimal peptide" is bound will the MHC-I be released and exported to the cell surface for presentation to T cells. The exact mechanisms of Tpn quality control and the criteria for

The Torrabaai-Koigabmond Complex (southern Kaoko Belt, Namibia) consists of three main intrusive rock types including metaluminous hornblende- and titanite-bearing quartz diorites, metaluminous hornblende- and biotite-bearing granodiorites and peraluminous garnet- and muscovite-bearing leucogranites. Uranium-Pb zircon data obtained on the granodiorites and leucogranites indicate concordia upper in

Articulatory data were collected for the Swedish vowels /iː, yˌ, ʉ̟ː/ from nine speakers each of Stockholm, Gothenburg, and Malmöhus Swedish, and the tongue positions and their dynamics analysed using Functional Data Analysis (FDA). Results showed that the general tongue positions for /iː/ and /yː/ are similar and clearly different from /ʉ̟ː/ in all three dialects. Variation within the Stockholm a

Malaria is a major global cause of deaths and a vaccine is urgently needed.

The immune system is remarkable in many ways. It exerts immunity to defend us from foreign pathogens, while it is also responsible for maintaining tolerance to avoid autoimmune diseases and allergy. This thesis includes three separate papers concerning both tolerance and immunity. In paper I we report that repeated antigen stimulation results in an increased proportion of Foxp3+ cells in the CD4+

The partial unfolding of human lysozyme underlies its conversion from the soluble state into amyloid fibrils observed in a fatal hereditary form of systemic amyloidosis. To understand the molecular origins of the disease, it is critical to characterize the structural and physicochemical properties of the amyloidogenic states of the protein. Here we provide a high-resolution view of the unfolding p

The proportions of Haemophilus influenzae resistant to ampicillin and other beta-lactam antibiotics have been low in Sweden compared to other countries in the Western world. However, a near-doubled proportion of nasopharyngeal Swedish H. influenzae isolates with resistance to beta-lactams has been observed in the last decade. In the present study, the epidemiology and mechanisms of antimicrobial r