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Increased body temperature accelerates aggregation of the (Leu-68–>Gln) mutant cystatin C, the amyloid-forming protein in hereditary cystatin C amyloid angiopathy

Hereditary cystatin C amyloid angiopathy is a dominantly inherited disorder, characterized by dementia, paralysis, and death from cerebral hemorrhage in early adult life. A variant of the cysteine proteinase inhibitor, cystatin C, is deposited as amyloid in the tissues of the patients and their spinal-fluid level of cystatin C is abnormally low. The disease-associated Leu-68-->Gln mutant (L68Q) cy

The State of Naming Conventions in R

Most programming language communities have naming conventions that are generally agreed upon, that is, a set of rules that governs how functions and variables are named. This is not the case with R, and a review of unofficial style guides and naming convention usage on CRAN shows that a number of different naming conventions are currently in use. Some naming conventions are, however, more popular

Food security and climate change in drought-sensitive savanna zones of Ghana

Desertification, climate variability and food security are closely linked through drought, land cover changes, and climate and biological feedbacks. In Ghana, only few studies have documented these linkages. To establish this link the study provides historical and predicted climatic changes for two drought sensitive agro-ecological zones in Ghana and further determines how these changes have influ

Is There an Optimal Strategic Oil Reserve for Each Country? A Study Based on the Game Theory

In generally, there is a phenomenon of “free rider” in the establishment of national oil reserves for different countries, which means that they have the tendency of underestimating the strategic oil reserves. This paper attempts to explain this phenomenon from the perspective of non-cooperative game theory. It also analyzes the establishment of strategic oil reserve among different countries base

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Potential water saving from rainwater harvesting in Syria

Syria, as well as many other countries in the Middle East, faces serious water shortage problems. Available water per capita (AWPC) will dramatically decrease due to climate change, population increase, and water needed for economic growth. Rainwater harvesting can play an important role in increasing available water in Syria. However, the absence of rainwater sewer systems in many rural areas in

Quinoa starch granules: a candidate for stabilising food-grade Pickering emulsions.

BACKGROUND: Particle-stabilised emulsions, so-called Pickering emulsions, are known to possess many beneficial properties, including being extremely stable. Starch granules isolated from quinoa have been used as emulsion stabilising particles. The granules were intact, 1-3 µm in diameter and modified with octenyl succinic anhydride to increase their hydrophobicity. Starch granules, as opposed to m

The Generalized Hill Model: A Kinematic Approach Towards Active Muscle Contraction.

Excitation-contraction coupling is the physiological process of converting an electrical stimulus into a mechanical response. In muscle, the electrical stimulus is an action potential and the mechanical response is active contraction. The classical Hill model characterizes muscle contraction though one contractile element, activated by electrical excitation, and two non-linear springs, one in seri

Management of hydrogen sulfide in anaerobic digestion of enzyme pretreated marine macro-algae

Enzymatic pretreatment of algae by means of cellulose degrading enzyme was evaluated through lab-scale and pilot-scale experiments. The degradation efficiency of the enzyme depended on the initial physical quality of the algae. Lab-scale batch anaerobic digestion experiments showed comparatively low methane potential for the pretreated algae at both mesophilic and thermophilic temperatures. Howeve

Multiconjugate adaptive optics for large telescopes: analytical control of the mirror shapes

We present an analytical algorithm for deriving the shapes of the deformable mirrors to be used for multiconjugate adaptive correction on a large telescope. The algorithm is optimal in the limit where the overlap of the wave-front contributions from relevant atmospheric layers probed by the guide stars is close to the size of the pupil. The fundamental principle for correction is based on a minimi

Does the Breast Cancer Age at Diagnosis Differ by Ethnicity? A Study on Immigrants to Sweden

Background. Age-specific incidence rates for breast cancer in low-risk and high-risk ethnic populations differ by age at which the incidence maximum is reached: around 50 years in low-risk populations and over 60 years in high-risk populations. The interpretation of these differences remains unsettled, one line primarily referring to biological differences, the second one to cohort effects of rapi

2D Electronic Spectroscopy Reveals Excitonic Structure in the Baseplate of a Chlorosome

In green photosynthetic bacteria, the chlorosome baseplate mediates excitation energy transfer from the interior of the light-harvesting chlorosome toward the reaction centers. However, the electronic states of the baseplate remain unexplored, hindering the mechanistic understanding of the baseplate as an excitation energy collector and mediator. Here we use two-dimensional spectroscopy to study t

Young activists, political horizons, and the Internet: adapting the net to one's puroses

Based on a series of interviews with young activists working in both parliamentarian and extra-parliamentarian contexts, this chapter underscores that political purposes steer the use of communication technology. This is an explicit position gainst technological determinism. The two different categories of activists generated two different kinds of civic cultures.