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Popular Abstract in Swedish Under de senaste två decennierna har transplantation av embryonal vävnad från ventrala mesencephalon, mitthjärnan, utvecklats till en möjlig terapi för Parkinson’s sjukdom. Ju bättre transplantatet återställer den dopaminerga neurotransmissionen, desto större blir den motoriska förbättringen hos patienten. Dessvärre dör över 90% av de dopaminerga nervcellerna under tranOver the past two decades, grafting of embryonic nigral tissue has developed into a feasible therapeutic strategy for Parkinson's disease (PD). It has become apparent that the degree of restoration of dopaminergic neurotransmission by the transplanted cells is highly correlated to the symptomatic relief. However, the efficacy of the treatment is still far from optimal: More than 90% of the grafted

Based on a series of interviews with young activists working in both parliamentarian and extra-parliamentarian contexts, this chapter underscores that political purposes steer the use of communication technology. This is an explicit position gainst technological determinism. The two different categories of activists generated two different kinds of civic cultures.

The current form-giving activity in industrial design is characterized by explorations that depend on the individual capability to mentally manipulate a solution space from which to select and express the intended result. Designers often rely on artistic experimentation, aesthetic inspiration, or product specifications. These approaches often lead to satisfactory results, but they could be augment

At Lund University Faculty of Technology a growing number of teachers develop active student learning methods. These methods can have some advantages in obtaining certain objectives with higher education. To take responsibility for the own learning process and also to learn how to independently handle information and use it in an adequate way are important skills to achieve during an university ed

In the present thesis molecular genetic methods were used to address different biological and clinical aspects of Philadelphia (Ph) chromosome-positive leukemias and the BCR and ABL genes. In the first study, children with Ph-positive chronic myeloid leukemia (CML) were found to have essentially the same breakpoint locations in BCR as adults, a pattern which differs from the one seen in Ph-positiv

Popular Abstract in Swedish BAKGRUND Hjärnskador till följd av otillräckligt blodflöde eller skallskador drabbar varje år ett stort antal människor i vårt land. Otillräckligt blodflöde till hjärnan (cerebral ischemi) uppträder vid en rad kliniska tillstånd, exempelvis slaganfall (stroke), hjärtstillestånd och gravt sänkt blodtryck. Hjärnskador till följd av våld mot huvudet (traumatiska hjärnskadIschemic and traumatic brain damage are major causes of disability and death. While much effort has been spent to develop pharmacological treatments for these conditions, no neuroprotective drugs are in clinical use. Neuronal death following ischemia and trauma occurs in selected cell populations of the brain at various time points after the insult. It is believed that death of neurons are in part

Aim. To study the association between anthropometric measures: body mass index (BMI), percent body fat, waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), waist-to-hip-to-height ratio (WHHR), and A Body Shape Index (ABSI); to see if individuals in the lowest 5 percentiles for these measures have an increased risk of mortality. Methods. A population-based prospective

We examined the independent and combined associations of physical activity and obesity with incident type 2 diabetes in men and women. The InterAct case-cohort study consists of 12,403 incident type 2 diabetes cases and a randomly selected subcohort of 16,154 individuals, drawn from a total cohort of 340,234 participants with 3.99 million person-years of follow-up. Physical activity was assessed b

Objective: The objective of the present study was to evaluate the pharmacokinetics and the clearance pathways of rFVIIa after intravenous administration to haemophilia patients. Methods: Ten severe haemophilia patients were included in the study; all patients were intravenously administered a clinical relevant dose of 90 μg/kg (1.8 nmol/kg) rFVIIa. Blood samples were collected consecutively to des

Haemophilus influenzae protein E (PE) is a multifunctional adhesin, involved in direct interactions with lung epithelial cells and host proteins, including plasminogen and the extracellular matrix proteins vitronectin and laminin. We recently crystallized PE and successfully collected X-ray diffraction data to 1.8 Å. Here we solved the structure of a recombinant version of PE and analyzed differen

Arsenic is carcinogenic, possibly partly through epigenetic mechanisms. We evaluated the effects of arsenic exposure and metabolism on DNA methylation. Arsenic exposure and methylation efficiency in 202 women in the Argentinean Andes were assessed from concentrations of arsenic metabolites in urine (inorganic arsenic, methylarsonic acid [MMA], and dimethylarsinic acid [DMA]), measured by HPLC-ICPM

Objectives. Endoscopic submucosal dissection (ESD) is an effective method for en bloc removal of large colorectal tumors in Japan, but this technique is not yet widely established in western countries. The purpose here was to report the experience of implementing colorectal ESD in Sweden. Methods. Twenty-nine patients with primarily nonmalignant and early colorectal neoplasms considered to be too

As corporations are going global, they are increasingly confronted with human rights challenges. As such, new ways to deal with human rights challenges in corporate operations must be developed as traditional governance mechanisms are not always able to tackle them. This article presents five different views on innovative solutions for the relationships between business and human rights that all b

We report on the performance of the third-order Douglas–Kroll ab initio model potential (DK3-AIMP) method-based electron-correlated spin–orbit calculations. Our treatment assumes that the problem can be separated into a spin–free correlation treatment and a spin–orbit calculation. The correlation effects were calculated using the multistate complete active space second-order perturbation method, a