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Proenkephalin (PENK) is assumed to be freely filtered by the glomerulus, thus potentially useful for estimating glomerular filtration rate (eGFR). Recently developed eGFR-equation based on PENK and creatinine has not been validated against existing cystatin C-based equations. This study aimed to test the hypothesis of free filtration of PENK. Also, the PENK-creatinine based eGFR-equation was valid
We have calculated redox potentials of 12 blue copper protein sites comparing 64 computational methods, systematically varying the quantum mechanics (QM) system size, dielectric constants, density functional, and basis sets. All methods were based on structures optimized with combined QM and molecular mechanics (QM/MM) approaches. The redox potentials were evaluated using 10 quality metrics. The b
Critical urbanists’ placement of smart city initiatives in Western Europe or North merica mostly on “low” rungs of participatory ladders or scaffolds does not mean that smart urban development connotes democracy-eroding neoliberalization everywhere. This article offers a more globally variegated and dynamic understanding of the relationship between citizens and smart cities. We apply an institutio
With the emergence of the so-called Blue Economy, various conservation finance mechanisms and financial structures are being proposed as a means of simultaneously securing marine biodiversity and profit-making. A novel approach that is being applied within this new conservation finance frontier is the integration of ecosystem-based adaptation and insurance. By synthesizing recent literatures in po
Responding to recent studies on the reception of Church Fathers, this paper contributes a study of how Jacques Lefèvre d'Étaples edited the writings of ps.-Dionysius the Areopagite in Latin. Focusing on how Lefèvre revised the Latin translation by Ambrogio Traversari (1386-1439), I argue that Lefèvre adapted Traversari's text to a new context by aligning the translation with earlier Latin renderin
This special issue of Climatic Change contains a series of research articles documenting co-ordinated work carried out within a 3-year European Union project 'Prediction of Regional scenarios and Uncertainties for Defining European Climate change risks and Effects' (PRUDENCE). The main objective of the PRUDENCE project was to provide high resolution climate change scenarios for Europe at the end o
The rapid progression of the electrification of road transport in many countries urges the need to make informed decisions on the location and size of the required charging infrastructure. This paper’s main contribution is a novel method to position fast-charging stations based on the transportation energy demand and to evaluate the performance of such charging infrastructure. Depending on their r
The aim of this paper is to begin a discussion on what role Environmental Humanities might play in policy-making, and in negotiating alternative ways of engaging with the environment in general, in the Faroe Islands. To approach these issues, it is necessary first to deal with what the absence of Environmental Humanities means in the Faroes and what Environmental Humanities would mean in a Faroese
TPA is known to cooperate with an activated Ras oncogene in the transformation of rodent fibroblasts, but the biochemical mechanisms responsible for this effect have not been established. In the present study we used c-fos promoter-luciferase constructs as reporters, in transient transfection assays, in NIH3T3 cells to assess the mechanism of this cooperation. We found a marked synergistic interac
My dissertation studies the frequently mentioned but never fully explored affinities between the writings of Juan Carlos Onetti and Juan José Saer. From the very beginning of their writing careers, both authors relate writing and narrating to an elusive search for meaning—in life and stories. Consequently, the scene of storytelling is of the utmost importance; how, when, by and to whom, and indeed
In the autumn of 1993 the subject of free trade in visual media was brought into the public eye as never before, at least within the European Union. The occasion was of course the much publicised near breakdown in the ongoing GATT-negotiations. The crux seemed to be that the US and the EU was unable to come to terms whereas films and television programmes was to be seen as manufactured goods which
