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Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models

The application of multiple omics technologies in biomedical cohorts has the potential to reveal patient-level disease characteristics and individualized response to treatment. However, the scale and heterogeneous nature of multi-modal data makes integration and inference a non-trivial task. We developed a deep-learning-based framework, multi-omics variational autoencoders (MOVE), to integrate suc

Cell-specific switch for epileptiform activity : critical role of interneurons in the mouse subicular network

During epileptic seizures, neuronal network activity is hyper synchronized whereby GABAergic parvalbumin-interneurons may have a key role. Previous studies have mostly utilized 4-aminopyridine to induce epileptiform discharges in brain slices from healthy animals. However, it is not clear if the seizure-triggering ability of parvalbumin-interneurons also holds true without the use of external conv

Immune response in blood before and after epileptic and psychogenic non-epileptic seizures

Inflammatory processes may provoke epileptic seizures and seizures may promote an immune reaction. Hence, the systemic immune reaction is a tempting diagnostic and prognostic marker in epilepsy. We explored the immune response before and after epileptic and psychogenic non-epileptic seizures (PNES). Serum samples collected from patients with videoEEG-verified temporal or frontal lobe epilepsy (TL

Policy brief: Paleoklimatet informerar oss om framtiden

Paleoklimatologi – läran om hur klimatet utvecklats genom jordens historia – ger oss referensramar för att sätta dagens klimat och möjliga framtida klimatförändringar i ett historiskt perspektiv. Till exempel visar nya analyser av historiska klimatarkiv att för norra halvklotet var perioden 1983-2012 sannolikt den varmaste på 1400 år. Vi ser även att vid den senaste värmeperioden, för 125 000 år s

Calculating Climate Debt. A Proposal

Abstract submitted to ISEE 2012 Theme: The Political Economy of Green Development By Rikard Warlenius PhD Candidate Human Ecology Division Lund University, Sweden 2011.11.24 Calculating Climate Debt. A Comparison and a Proposal The notion of climate debt has invoked widespread interest in the last few years. First conceptualized in 1999 within the Millennium movement for (financial) debt cancella

Why can't I sit with my friend ? The complexity in diverse anti-discriminatory practices in school.

The UN Convention on the Rights of the Child state that in all actions concerning children the best interests of the child shall be a primary consideration. Children are capable of forming their own views and have the right to express those views freely. The school plays an important role in empowering children in this socialization process and Swedish schools have in its educational assignment a

Bone Scan Index as an Imaging Biomarker in Metastatic Castration-resistant Prostate Cancer : A Multicentre Study Based on Patients Treated with Abiraterone Acetate (Zytiga) in Clinical Practice

Background Abiraterone acetate (AA) prolongs survival in metastatic castration-resistant prostate cancer (mCRPC) patients. To measure treatment response accurately in bone, quantitative methods are needed. The Bone Scan Index (BSI), a prognostic imaging biomarker, reflects the tumour burden in bone as a percentage of the total skeletal mass calculated from bone scintigraphy. Objective To evaluate

Exploring the influence of sustainable entrepreneurship education on sustainable opportunity recognition.

This study explores the influence of sustainable entrepreneurship education (SEE) on the ability to recognize sustainable business opportunities. Using a series of semi-structured qualitative interviews, data was collected from participants in a SEE program at Lund University. The findings reveal that SEE enhances the ability of students to identify and evaluate sustainable business opportunities

Design of a case erecting and product placement station

This report presents an innovative approach to industrial automation, focusing on the development of an automated system for erecting and filling cardboard boxes with wax jars. The project, executed in collaboration with Odigo Consulting and Scandinavian Hair Company (SHC), aimed to showcase enhanced production efficiency for small and medium-sized enterprises through the implementation of co

Investigation of the Possibility to Implement a Heat Pump for the Recovery of Heat From Process Cooling Water

This report aims to investigate the possibilities to implement a high temperature heat pump at a Dow facility in Landskrona. By implementing a heat pump, waste heat from the production can be recovered and reused in the process. The question at issue is whether there will be enough energy available when needed due to an intermittent process, and if a heat pump will be feasible to implement. To inv

Ergonomic Design of a New Assembly Skid - A Case Study at a Swedish Truck Manufacturing Company

This thesis project was performed in collaboration with Scania CV AB’s cab factory in Oskarshamn, Sweden, and the objective was to accomplish a product development process regarding a new assembly skid from an ergonomic perspective. A great number of aspects had to be noticed and evaluated, both regarding the process the skid is aiming to support and the product it concerns. The focus was the func

Mind the Gaps - A Legal Dogmatic Study on Service Provision for Returning Human Trafficking Victims in Vietnam

With a legal dogmatic method, the purpose of this thesis was to examine how Vietnam is fulfilling its legal obligations to support returning human trafficking victims. The Vietnamese human trafficking law was the main research object and was considered in relation to the international standards in support to returnees set in the Trafficking Protocol. It also aimed to identify shortcomings, and ass