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BackgroundImmune-related hepatitis (ir-hepatitis) ranks among the most frequent adverse events of immune checkpoint inhibitors (ICIs). Limited knowledge exists regarding the incidence, characteristics, and treatment of patients having an inadequate response to initial therapy with steroids. Characterizing ir-hepatitis phenotypes and treatment responses can provide valuable insights for guiding tre

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Accurate forest aboveground biomass (AGB) estimation across heterogeneous subtropical regions is essential for carbon accounting and climate change mitigation. We developed XGBoost and random forest models using GEDI L4A Lidar samples and multi-source remote sensing features (Sentinel-1/2, topography) to predict AGB in Xijiang Forest Farm (Guangdong) and transferred them to Simao District (Yunnan)

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Understanding the spatiotemporal dynamics of dissolved organic carbon (DOC) is essential for predicting aquatic carbon fluxes and managing water quality in boreal catchments. Traditional DOC modelling approaches are limited in their ability to represent seasonal dynamics, event-driven responses, and riparian-zone contributions. Here, we evaluate the performance of the Krycklan-HYPE model in simula

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Monitoring atmospheric CO2 concentration changes across China is crucial for reducing carbon emissions and tackling global warming. Due to monitoring gap in satellite observations, this paper uses the Extremely Randomized Trees (ERT) model alongside OCO-2 satellite data and predictor variables to develop a 0.1° high-resolution monthly dataset of column-averaged dry air CO2 mole fraction (XCO2) in

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Monitoring ecosystems at regional or continental scales is paramount for biodiversity conservation, climate change mitigation, and sustainable land management. Effective monitoring requires satellite imagery with both high spatial resolution and high temporal resolution. However, there is currently no single, freely available data source that fulfills these needs. A seamless fusion of data from th

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Solar energy is an important source of clean energy to combat climate change issues that motivate the establishment of solar farms. Establishing solar farms has been considered a proper alternative for energy production in countries like Mozambique, which need reliable and clean sources of energy for sustainable development. However, selecting proper sites for creating solar farms is a function of

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In this study, we assess the impact of an image restoration pipeline, designed for digital mammography, on the detectability of microcalcifications of different sizes across varied radiation exposures. The restoration pipeline first removes the noise of the image considering a Poisson-Gaussian noise model that incorporates quantum and electronic noise. Then, it appropriately merges the noisy and d

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Background: Postoperative management after surgery for perforated peptic ulcer is still burdened by old traditions. All available data for fast-track recovery in this setting are either very unspecific or underpowered. The aim of this study was to evaluate fast-track recovery in this diagnosis-specific context in a larger sample. Methods: Electronic data sources were searched. Eligible studies wer

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1. In order to prove a copyright exception not contemplated in the Act but based on long-standing practice the defendant must show strong evidence that goes beyond a usual practice in the business.2. The use of a copyright-protected work even in a commercial or marketing context can be of such secondary importance that – notwithstanding that the rights holder has not permitted the use – it would nThe present article grapples with the concept of de minimis in European copyright law in light of the ruling by the Danish Supreme Court in Würtz v Coop Denmark. The article begins with a brief background of the case. The second section delves into the concept of de minimis and its origins and framing in European copyright law. The third section compares the concept to US legislation and case law

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Simultaneous sound event localization and detection (SELD) for multi-source sound events is an open research field. The Multi-ACCDOA format is a popular way to handle activity-coupled sound events where the same class occurs at multiple locations at the same time. An important part is the Auxiliary Duplicating Permutation Invariant Training (ADPIT) paradigm that calculates the loss for order-agnos

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IntroductionData regarding the impact of adenomyosis on the outcomes after in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment are conflicting. Standardized diagnostic criteria are prerequisites for studying a potential association between adenomyosis and IVF/ICSI treatment outcomes. This study aims to examine the cumulative live birth rate (CLBR) after the first IVF/

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This study spatially analyzes plant phenology and its variations over time in mainland Spain and the Balearic Islands. To conduct the analysis, a nearly 40-year span time series (1983-2020) was generated by merging NDVI vegetation index values from satellite images sourced from NOAA-AVHRR and MODIS sensors. The phenological variables were calculated using TIMESAT 3.3, which extracted 13 phenometri

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This study analyzes the relationship between drought processes and crop yields in Moldova, together with the effects of possible future climate change on crops. The severity of drought is analyzed over time in Moldova using the Standard Precipitation Index, the Standardized Precipitation Evapotranspiration Index, and their relationship with crop yields. In addition, rainfall variability and its re

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The spatial imprint of forest disturbances, which can result from a variety of anthropogenic and natural causes, is important in shaping the form and function of the world’s forests. However, we lack a systematic assessment of how the forms of forest disturbances differ globally, which could help in sustainable forest policy and management initiatives to protect forest biomes. Here we produce a gl

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Increasing water stress is emerging as a global phenomenon, and is anticipated to have a marked impact on forest function. The role of tree functional strategies is pivotal in regulating forest fitness and their ability to cope with water stress. However, how the functional strategies found at the tree or species level scale up to characterise forest communities and their variation across regions

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This research explores herbaceous biomass estimation in African rangelands through remote sensing, emphasizing challenges and uncertainties. Comparing remote sensing data with ground validation, the study addresses spatiotemporal variations, employing advanced models and validation techniques. Harmonizing and calibrating ground data from four African countries, the research provides insights into

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Forests have seen a strong greening trend worldwide, and previous studies have attributed this mainly to land-use conversions such as afforestation. However, for the greening of existing forests, the role of human interventions is unclear. Here we paired neighboring natural and planted forests in Southern China to minimize the differences between the forest types and analyzed the vegetation index

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The Amazon rainforest is highly biodiverse and has the largest extent of the remaining intact tropical forests in the world. To this day, undisturbed tropical forests act as a carbon sink by taking up about 15% of anthropogenic carbon emissions per year. However, in the past decades, a declining trend in the carbon sink capacity in the Amazon rainforest has been observed due to increased carbon lo

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Northern ecosystems, encompassing boreal forests, tundra, and permafrost areas, are increasingly affected by the amplified impacts of climate change. These ecosystems play a crucial role in determining the global carbon budget. To improve our understanding of carbon uptake in these regions, we evaluate the effectiveness of employing the physically-based Plant Phenology Index (PPI) to estimate gros