Sökresultat

Society is becoming increasingly dynamic and complex, and therefore more vulnerable. It is thus important that society is resilient in order to be able to protect citizens and critical functions in the wake of disasters. It has been suggested that disaster risk reduction (DRR) is key in establishing resilience, and that adequate capacity in DRR is vital to reduce the effects of disasters. DRR and

Huntington's disease (HD) is a fatal neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin (htt) gene. Neuropathology is most severe in the striatum and cerebral cortex. As mutant htt is ubiquitously expressed, it has not been possible to establish clear structure-to-function relationships for the clinical aspects. In the present study, we have injected recombinant adeno-as

Huntington disease (HD) is a fatal neurodegenerative disorder caused by expansion of a CAG repeat in the HD gene. Degeneration concentrating in the basal ganglia has been thought to account for the characteristic psychiatric symptoms, cognitive decline and motor dysfunction. However, the homeostatic control of emotions and metabolism are disturbed early in HD, and focused studies have identified a

Background The impact of the prophylactic vaccine against human papillomavirus (HPV) types 6, 11, 16, and 18 (HPV6/11/16/18) on all HPV-associated genital disease was investigated in a population that approximates sexually naive women in that they were "negative to 14 HPV types" and in a mixed population of HPV-exposed and -unexposed women (intention-to-treat group). Methods This analysis studied

Dopamine replacement for Parkinson's disease (PD) have seen three major iterations of improvements since the introduction of l-3,4-dihydroxyphenylalanine (l-DOPA) pharmacotherapy: dopamine receptor agonists, ex vivo gene transfer for cell transplantation and most recently in vivo gene therapy. In this chapter, we describe the principles behind viral vector-mediated enzyme replacement in PD. We foc

In Huntington's disease (HD), the mutant huntingtin protein is ubiquitously expressed. The disease was considered to be limited to the basal ganglia, but recent studies have suggested a more widespread pathology involving hypothalamic dysfunction. Here we tested the hypothesis that expression of mutant huntingtin in the hypothalamus causes metabolic abnormalities. First, we showed that bacterial a

Viral vector-mediated gene transfer utilizing adeno-associated viral vectors has recently entered clinical testing as a novel tool for delivery of therapeutic agents to the brain. Clinical trials in Parkinson's disease using adeno-associated viral vector-based gene therapy have shown the safety of the approach. Further efforts in this area will show if gene-based approaches can rival the therapeut

OBJECTIVES: the purpose of this study was to assess the predictive accuracy of conventional cardiovascular risk factors for incident heart failure and atrial fibrillation, and the added benefit of multiple biomarkers reflecting diverse pathophysiological pathways. BACKGROUND: heart failure and atrial fibrillation are interrelated cardiac diseases associated with substantial morbidity and mortality

Key Messages • Sweden has an ideal opportunity to become a more important effect, reflecting the views of several Swedish organisations active international partner in DRR and resilience activities, originating in this area. from its strong history of donor support and long engagement • Acting on this opportunity would enable timely Swedish in DRR. contributions to the increasing global debate on

The last ten years have seen a sharp increase in externally supported capacity development initiatives for disaster risk management. However, not all of them have generated sustainable results. The purpose of this paper is to scrutinize the current focus on training as the main tool for capacity development in the context of disaster risk management, and to argue for the necessity to address capac

Introduction Many kinds of footwear are used for various purposes in the workplace in Japan. Careful selection of footwear is needed to protect workers from coldness and to keep the performance of workers in cold workplace where employees have to work under -20℃. On the other hand, safety boots with high heat conductivity from foot to outside are needed for the workers in hot environments. But the

Southern Africa suffers from an acute lack in skilled capacities for disaster risk reduction and climate change adaptation. The region, with its unique disaster risk profile, is mostly bound by its inability to effect change and transformation for sustainable development and resilience building. Reasons for these limitations are largely due to the lack of capacities in disaster risk reduction with

Societal safety and sustainability are key challenges in our complex and dynamic world, causing growth in interest of applying the concept of resilience in broader societal contexts. This paper presents a concept of Community Resilience that builds on established theory of Resilience Engineering and operationalises the concept by presenting its purpose, required functions and a way to identify and

Reconfigurable intelligent surface (RIS) can manipulate the electromagnetic (EM) waves in wireless channels and thus is promising for the sixth generation wireless communication systems. However, there exists little research on RIS channel measurements, which are important for the communication system design. In this paper, channel measurements are carried out in anechoic chamber, outdoor, and ind

Background: The European Union (EU) AI Act (AIA) aims to facilitate trustworthy Artificial Intelligence (AI) systems, especially for safety-critical use cases. Compliance with this new regulation entails a multitude of legal, technical, and organizational challenges for the providers of affected systems.Objective: This regulatory compliance engineering research aims for an empirical exploration an

Background: Magnetic resonance imaging (MRI) is recommended by guidelines to evaluate the severity of brain ischemia after cardiac arrest for functional outcome prediction. However, standardized assessment criteria are lacking. We have developed a semi-quantitative Cardiac Arrest Brain Ischemia (CABI) score to assess the extension of brain ischemia on MRI. Objectives: To evaluate the prognostic pe

Cutting edge preparation is crucial in metal cutting as the edge geometry significantly influences both the material removal process and tool life. However, an analytical model that can physically describe the cutting edge preparation process has not yet been established. Taking the wet abrasive jet machining (WAJM) method as an example, the following questions always remain: Why does WAJM always

Motivationen med studien var den alldeles för höga stråldosen som används vid CTundersökningar. I de allra flesta fallen anpassas man inte rörströmmen efter patientens storlek och därmed får smalare patienter en onödigt hög stråldos. Målet var att reducera stråldosen till patienter som undersöks med datortomografi utan att minska på bildkvalité, genom att anpassa rörströmmen efter patientens stoIn this study we have investigated the possibilities of dose reduction in CT at a constant level of image quality by adjustment of the tube current to the phantom size. The motivation with the study is the high radiation doses to the patients and the increasing frequency of CT examinations and the variety of examinations in CT, and that the same tube current is used for different patient sizes. Ac

Background: Branch-duct intraductal papillary mucinous neoplasm (BD-IPMN) presents a clinical conundrum. Rigorous long-term surveillance or surgical resection is recommended. The economic consequences of the management have not been fully investigated. Methods: A Markov decision model compared 4 strategies for low-risk BD-IPMN: I = upfront total pancreatectomy, II = upfront partial pancreatectomy,

We have prepared electrodes for photo-electro-chemical cells which have enabled to pre-charge colloidal quantum dots in well-controlled fashion. Femtosecond transient absorption measurements were carried out revealing clear speed-up of the photo-induced charge carrier dynamics, particularly the recombination. Such studies allow to understand the behavior of light harvesting materials in operationa