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Purpose To explore the effect of high-dose ifosfamide in first-line treatment for patients <= 40 years of age with nonmetastatic osteosarcoma of the extremity. Patients and Methods From March 1997 to September 2000, 182 patients were evaluated. Primary treatment consisted of two blocks of high-dose ifosfamide (15 g/m(2)), methotrexate (12 g/m(2)), cisplatin (120 mg/m(2)), and doxorubicin (75 mg/m(
Background: von Willebrand disease (VWD) type 1 is a congenital bleeding disorder caused by genetic defects in the von Willebrand factor (VWF) gene and characterized by a reduction of structurally normal VWF. The diagnosis of type 1 VWD is difficult because of clinical and laboratory variability. Furthermore, inconsistency of linkage between type 1 VWD and the VWF locus has been reported. Objectiv
A method has been developed for establishing a "University Without Walls" for the purpose of studying the relationship between electrocardiographic estimation and magnetic resonance imaging measurements of myocardial infarct size. The research team includes faculty and students from 4 medical centers, with expertise extending from clinical to technical. Weekly interactive videoconferences provide
[1] The timing of magmatic events forming Jurassic basaltic rocks in Dronning Maud Land (DML), Antarctica, and hydrothermal activity that affected them is addressed with detailed Ar-40/Ar-39 incremental heating dating of feldspars. Plagioclase from an Utpostane gabbro and from a Kirwanveggen dolerite dike yield indistinguishable plateau ages at 177 +/- 1.8 Ma. Because of geologic controls, this es
The present contribution focuses on the mathematical techniques used to solve steady state metabolic models for the case of an overdetermined system. Even when parts of the system are underdetermined it is possible to solve the model partially and obtain statistically meaningful results. This is illustrated with data gathered from a set of E. coli W3110.shik1 phosphate- or carbon-limited continuou
Forum för ofrivilligt celibata män, incels, har fått mycket uppmärksamhet från den samhällsvetenskapliga forskningen på grund av dess våldsbejakande och hatiska natur. Detta fokus ifrågasätts i denna studie då det bidrar till att fenomenet ofrivilligt celibata ofta ses som en manlig företeelse, vilket osynliggör ofrivilligt celibata kvinnors, femcels, uteslutning ur romantik i dagens samhälle. I d
This essay deals with the so-called Islamic State´s propaganda paper Dabiq and how the use of history in it helps create historically based depictions of the Islamic State´s enemies. I have analysed the first four issues of Dabiq from 2014 and used Jakob Dahlbacka´s definition of religious use of history and prophetic use of history as an analytical frame. I have analysed both text and images in D
Received remittances around the world has experienced a large increase during the last decades. This study investigates the effect that remittances have on economic growth, by using annual panel data from 81 countries from the last four decades. In the paper we divide our data into seven different periods to observe the long-term relationship through regression analysis. Our results indicate that
This paper contributes to sustainability transitions studies in delivering stronger focus and relevance on culture and discursive features to apprehend social resistances towards transition agendas, and the unprecedented emergence of the challenging antagonism of the ‘end of the world’ versus ‘the end of the month’ revealed by the case study of the Yellow Vests crisis in France since November 2018
Storskaliga våldsamheter mot medlemmar av folkgruppen Rohingya i Myanmar har sedan augusti 2017 lett till över 10 000 människors död och tvingat nära en miljon människor att fly till grannlandet Bangladesh. Som respons på händelserna inledde Gambia i november 2019 förfaranden i Internationella domstolen (ICJ) mot Myanmar och några dagar senare auktoriserades Internationella brottmålsdomstolens (ICAtrocities against members of the Rohingya group in Myanmar have since August 2017 resulted in over 10 000 deaths and close to one million people being forced to flee into neighbouring Bangladesh. In response to these events, The Gambia instituted proceedings against Myanmar before the International Court of Justice (ICJ) in November 2019. A few days later, the Prosecutor of the International Crim
By performing a field experiment within behavioural economics with focus on creating a nudge, this study enables to investigate whether a nudge that create better awareness have ability to influence individuals to make a more environmental friendly decision. By performing a field experiment in cooperation with Länsförsäkringar Skåne, the study shows that the nudges have a significant impact of rai
The outbreak of the COVID-19 pandemic in November 2019, has made a huge impact on the stock market. Thus, this paper aims to analyze how big of an impact the pandemic shocks have compared to other known shocks on the market. The study focuses on financial services companies due to the limited work that views the effect of pandemic driven shocks on this sector. The study conducted two samples of da
Den här uppsatsen undersöker den svenska implementeringen av andelsbytesmekanismen för privatpersoner, som återfinns i artikel 8 i Fusions-Direktivet, hädanefter FD. Uppsatsen undersöker även hur Sverige har valt att skydda sin beskattningsrätt när aktieägaren emigrerar till en annan EU MS medan hen äger aktier erhållna via ett andelsbyte. Syftet bakom undersökningen är att utreda huruvida om den This thesis examines the Swedish implementation of the exchange of shares mechanism for individuals, found in article 8 of the Tax Merger Directive, henceforth TMD, and how Sweden has chosen to safeguard its taxation right when the shareholder holding exchanged shares emigrates to another EU MS. The purpose behind this is to examine if the Swedish im-plementation, given the more recent case-law fr
DNA is presently at the centre of a storm. On the one hand, the breathtaking development of DNA related sciences during the last decades led to a technological and medical revolution. Due to the far reaching possibilities connected to this technology, it is the focus of many people’s interest and one source of the hope that one day we will find cures for terrible illnesses. Unsurprisingly, DNA re
Regional cerebral blood flow was measured with the 133-Xenon inhalation method in seven healthy subjects with orthostatic hypotension not due to autonomic failure (i.e. non-neurogenic clinical disorder). Measurements were performed during supine rest and during head-up tilt (70 degrees). All subjects had a consistent drop in systolic blood pressure and the typical symptomatology of orthostatic hyp
Duplicative horizontal gene transfer may bring two previously separated homologous genes together, which may raise questions about the interplay between the gene products. One such gene pair is the “native” PgiC1 and “foreign” PgiC2 in the perennial grass Festuca ovina. Both PgiC1 and PgiC2 encode cytosolic phosphoglucose isomerase, a dimeric enzyme whose proper binding is functionally essential.
Air pollution is recognized as the most important environmental factor that adversely affects human and societal wellbeing. Due to rapid urbanization, air pollution levels are increasing in the Sub-Saharan region, but there is a shortage of air pollution monitoring. Hence, exposure data to use as a base for exposure modelling and health effect assessments is also lacking. In this study, low-cost s
Aims: Ankle–brachial index (ABI) is the most commonly used test when diagnosing peripheral vascular disease and is considered a marker for cardiovascular risk. Transcutaneous oxygen pressure (TcPO2), a test associated with microvascular function, has in several studies shown better correlation with diabetic foot ulcer (DFU) healing. Whether a low TcPO2 could be a marker for mortality in the high-r
Background: High-level sports have been described as a risk situation for mental health problems and substance misuse. This, however, has been sparsely studied for problem gambling, and it is unknown whether problem gaming, corresponding to the tentative diagnosis of internet gaming disorder, may be overrepresented in athletes. This study aimed to study the prevalence and correlates of problem gam
