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Aims. Chronotropic incompetence and impaired heart rate (HR) recovery are related to mortality. Guidelines lack specific reference values for HR recovery. We defined normal values and studied blunted HR response and recovery and mortality risk. Methods and results. We included 9917 subjects (45% females) aged 18–85 years who performed a cycle exercise test. We defined normal values for peak HR, HR

Background: Chronic or recurrent rhinosinusitis without polyps (CRSsNP) is characterized by a persistent inflammation of the sinonasal mucosa. The underlying cause is unclear but increasing interest has been directed toward changes in the sinonasal microbiome as a potential driver. Methods: Twenty-two patients diagnosed with CRSsNP were treated with antibiotics for 13 days, followed by 5 consecuti

BACKGROUND: Access to adequate pain treatment is a fundamental right, yet international data suggest that a considerable number of children experience acute and persistent pain. Little is known about the occurrence of both acute and persistent pain in children. The incidence of persistent postoperative pain in children is an unexplored area but international studies suggest that many children expe

Background: To support care after discharge following surgery for anorectal malformations (ARM) and Hirschsprung's disease (HD), an eHealth device was invented, offering families bilateral communication through chat, photo, questionaries and video. Aim: To explore the impact of eHealth on postoperative patterns of expert consultation, complications and treatment after discharge following surgery f

Purpose Children living with respiratory support rely on medical technology, either fully or partially, throughout the day to meet their breathing requirements. Although children and young people living with respiratory support at home undergo long-term treatments and make extensive use of health and social care services, there is a notable absence of comprehensive outcome data on this group. The

Objective: The primary aim of this study was to explore the lessons learned from implementing a procedure of resuscitation and stabilization with an intact umbilical cord for preterm and term infants requiring resuscitation or stabilization during emergency caesarean sections. Methods: Data were collected by two focus group discussions and one individual interview. Participants were members of imp

Strenuous physical activity can negatively affect constitutive innate immune function (CIF), the always present first line of defence against pathogens. CIF is non-specific, and thus vital when encountering novel pathogens. A lowered CIF likely increases the risk of infection and disease. Migratory birds engage in truly extreme physical activity during their endurance flights, however, little is k

Digital technologies have enabled novel forms and reconfigurations of value creation, delivery, and capture. These new reconfigurations challenge the conventional notion of value creation with digital business models. On that premise, the widening of privacy concerns, alert us that organizations of the elite digital, like Netflix, Amazon, and Spotify, design technology to feed on personal data, ba

In this paper, we propose a new system-level design language, called SystemJ. It extends Java with synchronous reactive features present in Esterel and asynchronous constructs suitable for modelling globally asynchronous locally synchronous systems. The strength of SystemJ comes from its ability to offer the data processing and encapsulation elegance of Java, Esterel-like reactivity and synchrony,

BACKGROUND: Accumulating evidence suggests a relationship between endometrial cancer and ovarian cancer. Independent genome-wide association studies (GWAS) for endometrial cancer and ovarian cancer have identified 16 and 27 risk regions, respectively, four of which overlap between the two cancers. We aimed to identify joint endometrial and ovarian cancer risk loci by performing a meta-analysis of

Soil erosion poses a significant environmental challenge in Dehradun due to its complex, steep terrain, heavy rainfall, and rapid urbanization. This study employed a Google Earth Engine-based approach to assess the average soil loss annually using the Revised Universal Soil Loss Equation (RUSLE). The analysis used various factors, including rainfall-runoff erosivity (R), soil erodibility (K), slop

Objectives: Both depression and suicidal behaviour have been associated with neuroinflammation. Galectin-3 (Gal-3), a protein involved in microglial activation, has been linked to pro-inflammatory cytokines and the severity of depressive symptoms. The extent to which peripheral levels of Gal-3 reflect neuroinflammation is unknown, as is the relationship between Gal-3 and suicidality. Methods: Bloo

The Cox Proportional Hazards (CPH) model has long been the preferred survival model for its explainability. However, to increase its predictive power beyond its linear log-risk, it was extended to utilize deep neural networks, sacrificing its explainability. In this work, we explore the potential of self-explaining neural networks (SENN) for survival analysis. We propose a new locally explainable

Objectives Critically ill COVID-19 patients admitted to the intensive care unit (ICU) are at an increased risk of acquiring bacterial bloodstream infections (BSI). We aimed to describe patient characteristics, risk factors, and the microbiological spectrum in blood cultures and evaluate the impact of ICU-acquired BSI on outcomes in a Nordic setting. Methods A prospective multicenter cohort study w

This study aims to explore how family therapists in social services perceive and describe quality in their work with family support, and how their experience and knowledge contribute to the quality of their practical work. The study was conducted through qualitative, semi-structured interviews with family therapists working within social services. The results reveal that professionals define quali

Hydroxyl radicals (HO•), produced through reactions between H2O2 and iron oxides, drive biogeochemical transformations, mediate organism toxicity, and facilitate advanced oxidation processes. The effectiveness of these processes depends on the spatial proximity between HO• generation and target substrates. Consequently, the oxidation mechanisms should be governed by interfacial interactions among

Accurate and continuous monitoring of inland surface‌ water dynamics is vital for sustainable water resource management, climate impact assessment, and ecological planning. This study introduces a machine learning-based remote sensing-based data-fusion framework that improves Sentinel-3 radar altimeter (SRAL) estimations of water surface elevation (WSE) by integrating ERA5 reanalysis climate varia

Cryo-scanning electron microscopy (CryoSEM) permits the preparation and detailed imaging of bulky samples while keeping them in a hydrated state. For plant biology, cryofractures give information on cell ultrastructure and tissue organisation within a much larger context that is the whole organ or organism. To date, a method to locate fluorescence reporters on the cryofracture has not been reporte

Expectations of and prerequisites for Swedish school libraries is the subject of this master’s thesis. The purpose of the thesis is to gain insights into what a school library is expected to be and what is required to achieve it. The thesis focuses on the trade union DIK's award “World class school libraries” which is meant to function as a set of criteria for what a well-functioning school li