Filtyp
"Få aspekter av tillvaron som inte har beröring med den akademiska världen" "Få aspekter av tillvaron som inte har beröring med den akademiska världen" Av Sofia Hermansson - Publicerad den 25 juni 2024 Universiteten har en lång och spännande historia och utgör idag en självklar stomme i världens kunskapssamhällen. I historieprofessor Johan Östlings nyutgivna "Kunskapens stora hus" (Makadam förlag)
Årsberättelse för forskarskolan i historia läsåret 2005 – 2006 Årsberättelse för forskarskolan i historia läsåret 2007 – 2008 Verksamhetsåret har i stor utsträckning präglats av Högskoleverkets utvärdering av de 16 nationella forskarskolorna, däribland forskarskolan i historia. Under året har tre disputationer och ett licentiatseminarium ägt rum. En ny antagningsomgång med sex nya studiestöd har g
Transcriptional profiling of epithelial ovarian cancer has revealed molecular subtypes correlating to biological and clinical features. We aimed to determine gene expression differences between malignant, benign and borderline serous ovarian tumors, and investigate similarities with the well-established intrinsic molecular subtypes of breast cancer.
Columnar cell hyperplasia (CCH) is the earliest histologically identifiable breast lesion linked to cancer progression and is characterized by increased proliferation, decreased apoptosis and elevated oestrogen receptor α (ERα) expression. The mechanisms underlying the initiation of these lesions have not been clarified but might involve early and fundamental changes in cancer progression. MiRNAs
When China opened it borders in 1979, the country suffered from a severe brain drain as its most talented students left the country to take advantage of educational opportunities abroad. However these emigrant engineers, known locally as "sea turtles" or Chinese returnees, have become a valuable asset for Zhongguancun Science Park. The authorities for the high-tech park are now adopting
Background. Diabetes may be linked to incidence of different tumor diseases and prognosis through various mechanisms such as the disease itself, hyperglycemia, obesity and anti-diabetes therapy. Material and methods. The study includes all women with BC diagnosed in Sweden between 2000 through 2008 (n=54406). The women had no previous cancer diagnosis during the period of 1958-1999. Dates of birth
Cyclin-dependent kinase 8 (CDK8) is a mediator complex-associated transcriptional regulator that acts depending on context and cell type. While primarily under investigation as potential cancer therapeutics, some inhibitors of CDK8—and its paralog CDK19—have been reported to affect the osteoblast lineage and bone formation. This study investigated the effects of two selective CDK8/19 inhibitors on
CONTEXT: Androgen deprivation therapy (ADT) is the backbone of treatment for advanced prostate cancer. However, castration-resistant prostate cancer (CRPC) nearly invariably develops through a range of different molecular mechanisms accompanied by progression to a more aggressive phenotype.OBJECTIVE: To understand the key molecular mechanisms leading to CRPC and the functional implications of this
I denna rapport sammanställer vi resultaten från en workshop med Hovedstadens Beredskab i Danmark. Workshopen utfördes som en del av projektet FIRE21 (Fire and Rescue Services in the 21st Century). I projektet studerar vi (forskare från Sverige, Norge och Danmark) hur räddningstjänster löser problem i så kallade problemlösande nätverk. Vi ser dessa som nödvändiga för att lösa problem i dagens och
BACKGROUND: Creatinine-based equations are the most used to estimate glomerular filtration rate (eGFR). The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), the re-expressed Lund-Malmö Revised (r-LMR) and the European Kidney Function Consortium (EKFC) equations are the most validated. The EKFC and r-LMR equations have been suggested to have better performances in young adults, but this
Syftet med studien var att undersöka om patienter som erhåller specialiserad palliativ hemsjukvård (SPH) får bättre palliativ vård, med färre besök på akutmottagning och vårddagar på sjukhus samt i högre utsträckning kan dö i sitt eget hem jämfört med de patienter som inte ansluts till SPH. Vi ville även undersöka om SPH är kostnadsbesparande.Genom retrospektiv journalgenomgång inkluderades de 150
Background Androgens acting via the androgen receptor (AR) stimulate production of prostate specific antigen (PSA), which is a clinical marker of prostate cancer (PCa). Since genetic variants in the AR may have a significant impact on the risk of being diagnosed with PCa, the aim was to investigate if AR-variants were associated with the risk of having PSA above clinically used cut-off thresholds
The androgen receptor (AR) is a key regulator of prostate tumorgenesis through actions that are not fully understood. We identified the repressor element (RE)-1 silencing transcription factor (REST) as a mediator of AR actions on gene repression. Chromatin immunoprecipitation showed that AR binds chromatin regions containing well-characterized cis-elements known to mediate REST transcriptional rep
A reproducible and quantitative imaging biomarker to standardize the evaluation of changes in bone scans is an unmet need for prostate cancer patients with skeletal metastasis. Here we have performed a series of analytical validation studies to evaluate the performance of the automated Bone Scan Index (BSI) as an imaging biomarker in patients with metastatic prostate cancer (mPCa).
