Sökresultat

Background: Recent research indicates a favourable influence of postmenopausal hormone therapy (HT) if initiated early, but not late, on subclinical atherosclerosis. However, the clinical relevance of timing of HT initiation for hard end points such as stroke remains to be determined. Further, no previous research has considered the timing of initiation of HT in relation to haemorrhagic stroke ris

We performed genome-wide association studies and found single nucleotide polymorphisms (SNPs) at seven independent loci associated with prostate-cancer-specific survival time. Two SNPs replicated in an independent cohort. The SNP rs73055188 at AOX1 is associated with AOX1 gene expression level, which is correlated with biochemical recurrence.

Objectives To conduct a comprehensive analysis of prospectively measured circulating high sensitivity C reactive protein (hsCRP) concentration and risk of lung cancer overall, by smoking status (never, former, and current smokers), and histological sub-type. Design Nested case-control study. setting 20 population based cohort studies in Asia, Europe, Australia, and the United States. ParticiPants

The receptor tyrosine kinase FLT3 is expressed almost exclusively in the hematopoietic compartment. Binding of its ligand, FLT3 ligand (FL), induces dimerization and activation of its intrinsic tyrosine kinase activity. This leads to autophosphorylation of FLT3 on several tyrosine residues which constitute high affinity binding sites for signal transduction molecules. Recruitment of these signal t

Human kallikrein peptidase 2 (hK2) is a prostate specific enzyme whose expression is governed by the androgen receptor (AR). AR is the central oncogenic driver of prostate cancer (PCa) and is also a key regulator of DNA repair in cancer. We report an innovative therapeutic strategy that exploits the hormone-DNA repair circuit to enable molecularly-specific alpha particle irradiation of PCa. Alpha-

Recently, we identified ELL2 as a susceptibility gene for multiple myeloma (MM). To understand its mechanism of action, we performed expression quantitative trait locus analysis in CD138+ plasma cells from 1630 MM patients from four populations. We show that the MM risk allele lowers ELL2 expression in these cells (P combined = 2.5 × 10-27; β combined = -0.24 SD), but not in peripheral blood or ot

A high acoustic energy density is required in the acoustic resonator to increase the throughput of acoustophoresis devices. In this study, through both experiments and numerical simulations, we find that the energy density in bulk-wave-acoustophoresis devices can be enhanced by actuating the device from the side. Based on qualitative free-flow focusing experiments, side actuation shows clear super

Although invasive species are recognized as a major threat to freshwaters, little is known about how future climate warming will affect the success of invaders. Ecosystems are also often simultaneously impacted by multiple, potentially interacting, invading species and the management of species invasions can be incredibly difficult. Sensitive methods such as environmental DNA (eDNA) metabarcoding,

Well-characterized archival formalin-fixed paraffin-embedded (FFPE) tissues are of much value for prospective biomarker discovery studies, and protocols that offer high throughput and good reproducibility are essential in proteomics. Therefore, we implemented efficient paraffin removal and protein extraction from FFPE tissues followed by an optimized two-enzyme digestion using suspension trapping

Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis. Genome-wide association studies have transformed our understanding of MM predisposition, but individual studies have had limited power to discover risk loci. Here we perform a meta-analysis of these GWAS, add a new GWAS and perform replication analyses resulting in 9,866 cases and 239,188 controls. We confirm all

Hypoxia and acidosis are inherent stress factors of the tumor microenvironment and have been linked to increased tumor aggressiveness and treatment resistance. Molecules involved in the adaptive mechanisms that drive stress-induced disease progression constitute interesting candidates of therapeutic intervention. Here, we provide evidence of a novel role of heparan sulfate proteoglycans (HSPG) in

BACKGROUND: Anti-neutrophil cytoplasmic antibodies associated vasculitides (AAV) is a group of autoimmune diseases, characterized by small vessel inflammation. Phagocytes such as neutrophils and monocytes are the main effector cells found around the inflamed vessel wall. Therefore, we wanted to investigate aspects of function and activation of these cells in patients with AAV.METHODS: Flow cytomet

Denna uppsats analyserar The Rush Limbaugh Show och den konservativa rörelsen i USA. Syftet med uppsatsen är att djupare förstå den konservativa rörelsen, deras kulturella värderingar och vilka problem de anser präglar det amerikanska samhället. Detta görs genom att analysera en av de största radiopratarna i USA, nämligen den konservativa mediepersonligheten Rush Limbaugh. Med hjälp av en framingaThis essay analyses The Rush Limbaugh Show and the conservative movement in America. The purpose of the essay is to deeper understand the conservative movement, their cultural values and the problems they think America is facing today. This is done by analyzing one of the biggest radio talk-shows in America, The Rush Limbaugh show, which is hosted by the famous conservative talk-show host Rush Lim

The presence of phytate in plants-based food is considered a threat to proper nutrition in developing countries and in particular in rural areas. There is evidence of micronutrient deficiencies due to the presence of phytate in plant-based diets. People from low income households are most affected by diets rich in phytate. The aim of this study was to investigate different processes through which

Research question: How does organizational culture, using complex adaptive systems perspective, influence problem creation process in the front end of innovation? Theoretical perspectives: Front end of innovation literature is the core subject of this thesis,focusing on problem creation process. Academic literature on organizational culture and complex adaptive systems is presented to show the re

Den rådande och även allmänt kända teorin för Universums uppkomst kallas Big Bang-teorin. Big Bang tros ha inträffat för cirka 13,8 miljarder år sedan och beskriver en tid när vårt Universum befann sig i ett mycket varmt och energitätt tillstånd, som snabbt kyldes ner för att bilda de första lätta atomkärnorna bara några minuter in i sitt unga liv. Även om det tog ytterligare 100 miljoner år förPrevious studies of two-particle correlation in proton-lead (pPb) collisions at \sqrt{s} = 5.02 TeV revealed a so-called double ridge structure similar to the one observed in lead-lead (PbPb) collisions. This structure features two distinct ridges extending over the entire \deta range (long-range correlations) at \Delta\phi \approx 0 (near-side) and \Delta\phi \approx \pi (away-side). A model base

Titel: Madison & Vine: Hur uppfattar konsumenter produktplacering i film? Seminariedatum: Januari 15, 2015 Kurs: FEKH29, Examensarbete i marknadsföring, 15 högskolepoäng Författare: Alinne Andersson, Lina Shore, Alexander Wegdell Handledare: Jon Bertilsson Nyckelord: Produktplacering, marknadsföring, varumärke, konsumentpåverkan, smygreklam Syfte: Målet med denna uppsats är att djupare undersö

Eftersom folkrätten är ett högaktuellt rättsområde idag, är det lätt att tro att det också är en modern produkt, ett resultat av nutidens accelererande globalisering. Så är dock inte fallet, utan folkrätten har i högsta grad en rättshistorisk sida som bör beaktas. Denna uppsats undersöker hur Hugo Grotius och Emer de Vattel behandlade de centrala folkrättsliga begreppen stat och suveränitet, och Since public international law is a current area of law today, we may think that it is also a modern product, a result of today’s globalized world. However, that is not the case. Public international law has important historical aspects that must be considered. This paper examines in what way Hugo Grotius and Emer de Vattel treated two of the key concepts of public international law, state and so