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Multigene expression signatures provide a molecular subdivision of early breast cancer associated with patient outcome. A gap remains in the validation of such signatures in clinical treatment groups of patients within population-based cohorts of unselected primary breast cancer representing contemporary disease stages and current treatments. A cohort of 3520 resectable breast cancers with RNA seq

The AIRE gene plays a key role in the development of central immune tolerance by promoting thymic presentation of tissue-specific molecules. Patients with AIRE-deficiency develop multiple autoimmune manifestations and display autoantibodies against the affected tissues. In 2016 it was reported that: i) the spectrum of autoantibodies in patients with AIRE-deficiency is much broader than previously

PURPOSE: The early loss of a parent is a tragedy and a serious life event. This study investigated grief resolution and morbidity in cancer-bereaved teenagers 6 to 9 years after the loss of a parent to cancer. METHODS: In a nationwide population-based study of 622 of 851 (73 %) youths who as teenagers 6 to 9 years earlier had lost a parent to cancer, we explored the magnitude of unresolved grief a

Background: Most validations of paediatric glomerular filtration rate (GFR) estimating equations using standardized creatinine (CR) and cystatin C (CYS) assays have comprised relatively small cohorts, which makes accuracy across subgroups of GFR, age, body mass index (BMI) and gender uncertain. To overcome this, a large cohort of children referred for GFR determination has been established from se

Innate immune responses are rapid, dynamic and highly regulated to avoid overt reactions. This regulation is executed by innate immune tolerance mechanisms that remain obscure. Wnt5a is a signalling protein mainly involved in developmental processes and cancer. The effect of Wnt5a on inflammatory myeloid cells is controversial. Here, we combine primary cell cultures, in vitro binding studies, mass

Objectives: Asthma and allergic diseases are the most frequent chronic diseases in childhood worldwide, and considered a burden for the affected children and their families. The diseases impose an economic burden on society if not diagnosed and treated properly and management of and these diseases are challenging for healthcare professionals. The aim of the present investigation was to assess the

PurposeIt is not known if mammographic breast compression of a primary tumor causes shedding of tumor cells into the circulatory system. Little is known about how the detection of circulating biomarkers such as circulating tumor cells (CTCs) or circulating tumor DNA (ctDNA) is affected by breast compression intervention.MethodsCTCs and ctDNA were analyzed in blood samples collected before and afte

Precision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes affects hundreds of millions of people worldwide, many of whom will develop life-threatening complications and die prematurely. Precision medicine can potentially address this enormous proble

Aim: Children born extremely preterm frequently have developmental coordination disorder (DCD). We aimed to evaluate perinatal risk factors for DCD. Methods: Swedish national cohort study including 226 children born before 27 gestational weeks without major neurodevelopmental disabilities at 6.5 years. Outcome was DCD, defined as ≤5th percentile on the Movement Assessment Battery for Children-Seco

Background: Pulmonary hypertension (PH) is frequent in patients with heart failure and reduced ejection fraction (HFrEF) with 2 different phenotypes: isolated postcapillary PH (IpcPH) and, with the worst prognosis, combined pre- and postcapillary PH (CpcPH). The aims of the present echocardiography study were to investigate (1) the ability to identify PH phenotype in patients with HFrEF using the

Context: In the contemporary body of software engineering literature, some recurrent shortcomings characterize how threats to validity (TTV) are considered in studies. Objective: With this position paper, we aim to open a discourse on the current use of TTV sections. The goal of our position is to jointly reflect and systematically improve how we, as a research community, consider TTV in our studi

En fastighetsaffär är för många privatpersoner den överlägset största affären de gör i hela livet. Varje år säljs och köps småhus för över 124 miljarder. En undersökning från Länsförsäkringar visar att en tredjedel av alla köpare oroar sig för förekomsten av ”dolda fel” i den köpta fastigheten. Mot bakgrund av den oron är det inte så konstigt att konsumentrådgivningar och liknande organisationer fA real estate transaction is for many individuals by far the largest transaction they make throughout life. Each year, sold and bought houses makes up for a value of more than 124 billion SEK. A survey, by the insurance company Länsförsäkringar, shows that one third of all buyers are concerned about the existence of "latent defects" in the purchased property. Given the turmoil, it is not

VAD SKA VI MED KYLTORN TILL? Vad skulle kyltorn kunna ha med Sveriges hållbarhetsmål att göra? Enorma mängder energi går åt till att kyla processer och det är inte helt osannolikt att den går till kyltorn. Att kyla med kyltorn är effektivt, men värmen är bortkastad till luften. Om man kunde göra något med energin skulle det kunna liknas med en outnyttjad guldåder. Sverige följer åtagandet i AgendAchieving a sustainable Swedish industry will require better utilization of resources already available and already spent. Nationally, vast amounts of heat are released into the atmosphere and not made use of. If only a fraction of this energy could be exploited, the path to net zero emission society by 2045 would be thousands of tons worth of CO2 closer. In Sweden, 25% of excess heat delivered to