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Protein S deficiency is a dominantly inherited disorder that results from mutations in the PROS] gene. Previous sequencing of the gene failed to detect mutations in eight out of 18 investigated Swedish families, whereas segregation analyses detected large deletions in three out of the eight families. The present study investigates more thoroughly for the presence of deletions but also for other ty
In high-risk pregnancies, the transport of oxygen and nutrients from maternal to fetal blood via the placenta is often impaired. To assess the risk, pulsed Doppler ultrasound (US) is used to evaluate the flow velocity waveform in the umbilical artery with the pulsatility index (PI), which is derived from the velocity envelope of the Doppler power spectrum. However, simply listening to the Doppler
An obstetrical paradox is that maternal smoking is protective for the development of preeclampsia. However, there are no prior studies investigating the risk of preeclampsia in women who were exposed to tobacco smoking during their own fetal period. We aimed to study the subsequent risk of preeclampsia in women who were exposed to tobacco smoke in utero, using a national population-based register.
OBJECTIVE: Screening of hypertension has been advocated for early detection and treatment. Severe hypertension (grade 3 hypertension) is a strong predictor for cardiovascular disease. This study aimed to evaluate not only the risk factors for developing severe hypertension, but also the prospective morbidity and mortality risk associated with severe hypertension in a population-based screening and
BACKGROUND: In a recent US cohort study, total coffee and tea consumption was inversely associated with risk of glioma, and experimental studies showed that caffeine can slow the invasive growth of glioblastoma. OBJECTIVE: The objective was to examine the relation between coffee and tea intake and the risk of glioma and meningioma in a large European cohort study, the European Prospective Investig
This paper presents RF as well as low-frequency capacitance–voltage (C–V) characterization of vertical wrap-gated InAs/high-κ nanowire MOS capacitors. A full equivalent circuit model for traps is used to fit the low-frequency C–V characteristics, from which the interface trap density (Dit) and border trap density (Nbt) are evaluated separately. The results show comparable Nbt but far lower Dit (<1
To estimate the effects of smoking, gender and occupational exposure on the risk of developing severe pulmonary fibrosis (PF), including dose-response and interaction effects.
The aim of this study was to examine breast density in relation to breast cancer specific survival and to assess if this potential association was modified by mode of detection. An additional aim was to study whether the established association between mode of detection and survival is modified by breast density.
We present a quantitative investigation of one- and two-body light-mediated processes that occur to few erbium atoms in an optical tweezer, when exposed to near-resonant light. In order to study the intertwined effects of recoil heating, cooling, and light-assisted collisions, we develop a first-principles Monte Carlo algorithm that solves the coupled dynamics of both the internal and external deg
BackgroundCytoreductive surgery is central to the management of advanced ovarian cancer. As the extent of surgery varies widely, assessment of postoperative risk is challenging. The Karolinska Surgical Extent and Complexity Score (K-SECS) was developed to quantify surgical extent and has previously been associated with survival. This study evaluated whether K-SECS is also associated with major pos
Objectives The aim of this study was to analyse associations between crowded housing and children’s indoor living environment, respiratory and allergic disorders and general health. Design A cross-sectional study. Setting Sweden, using data from the Swedish National Environmental Health Survey 2019. Participants The study sample included 48 512 children (aged 6–10 months, 4 years and 12 years). We
BACKGROUND AND OBJECTIVE: Prostate cancer (PC) and dementia may commonly co-occur; yet, prior evidence for bidirectional associations is inconsistent. This study aims to determine the associations between PC and dementia in large population-based studies, which may further inform clinical care. METHODS: To assess the dementia risk in men with PC, a national cohort study was conducted in 178 746 me
Tattoo ink on the European market has been reported to contain many human toxicants, which has raised concerns about health effects. Clarifying the exposure distribution in the population is key to understanding potential public health implications. We investigated the prevalence of tattoos in a population-based Swedish cohort of 13 046 individuals aged 20–68 years with exposure data collected thr
Rationale: There is no consensus on criteria to include in an asthma remission definition in real life. Factors associated with achieving remission after biologic initiation remain poorly understood. Objectives: To quantify the proportion of adults with severe asthma achieving multidomain-defined remission after biologic initiation and identify prebiologic characteristics associated with achieving
Background: The Influenza – Monitoring Vaccine Effectiveness in Europe (I-MOVE/I-MOVE+) and Vaccine Effectiveness, Burden and Impact Studies (VEBIS) hospital networks have conducted seasonal multicentre, test-negative, case–control studies in Europe to measure influenza vaccine effectiveness (IVE) since 2015/16. We measured the effect of chronic conditions on VE of influenza A subtypes among older
Background: Streptococcus pneumoniae is the primary cause of hospitalized community-acquired pneumonia (CAP). Mycoplasma pneumoniae, though typically causing mild respiratory disease, can lead to pneumonia requiring hospitalization in adults. This study compared patients hospitalized with CAP caused by M. pneumoniae or S. pneumoniae aiming at increasing the understanding of when to sample for and
Let v1 and v2 be two distinct vertices of an equilateral tree T0. Let ϕN(i) (i=1,2) be the characteristic functions of the Sturm-Liouville problem on T0 rooted at vi with Neumann conditions at the root and let ϕD(i) (i=1,2) be the characteristic functions of the Sturm-Liouville problem on T0 with Dirichlet conditions at the root. We prove that if attaching any tree to T0 at the vertices v1 and v2
While pregnancy clearly reduces the risk for Alcohol Use Disorder (AUD) onset, we know less about the impact on AUD risk of having young children and how these effects vary across maternal age and level of maternal AUD genetic risk. Therefore, in 1.2 million parous Swedish women born 1960-1995, we examined those with a first registration for AUD between ages 15-40 while first pregnant, or while ra
