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Pneumococcal surface protein A (PspA) is an important virulence factor in Streptococcus pneumoniae that binds to lactoferrin and protects the bacterium from the bactericidal action of lactoferricins—cationic peptides released upon lactoferrin proteolysis. The present study investigated if PspA can prevent killing by another cationic peptide, indolicidin. PspA-negative pneumococci were more sensiti
Mitotic cells attenuate the DNA damage response (DDR) by phosphorylating 53BP1, a critical DDR mediator, to prevent its localization to damaged chromatin. Timely dephosphorylation of 53BP1 is critical for genome integrity, as premature recruitment of 53BP1 to DNA lesions impairs mitotic fidelity. Protein phosphatase 4 (PP4) dephosphorylates 53BP1 in late mitosis to allow its recruitment to DNA les
BACKGROUND AND PURPOSE: Data on the prevalence and indicators of weight loss in population-based groups of stroke survivors are scarce. We aimed to find the predictors and indicators of weight loss >3 kg as a possible marker of malnutrition after stroke. METHODS: We registered weight at baseline, after 4 months, and 1 year later in 305 survivors from a population-based cohort of first-ever st
Universitetslektor Kontaktinformation E-post: andres [dot] palacio [at] ekh [dot] lu [dot] se Telefon: +46 46 222 01 51Organisation Ekonomisk-historiska institutionen Besöksadress: Scheelevägen 15 B, Lund Rumsnummer: Alfa 1:2057 Hämtställe: 10 WebbplatsAndrés Palacios profil i Lunds universitets forskningsportalAndra roller Universitetslektor Ekonomisk demografi Forskare Centrum för Mellanösternst
https://www.ehl.lu.se/andres-palacio - 2026-07-21
In the latest World Tourism Barometer, UNWTO (2020) predicts that global tourism could decline by up to 80% this year. While many tourism-dependent economies in Europe are currently suffering from under-tourism, the heated debate between tourism developers and local stakeholders about adverse impacts of over-tourism is likely to reignite even stronger once the inrush of tourists returns. As a resu
Antibiotika-resistens utgör ett ökande hälsoproblem i världen och bakterier blir alltmer resistenta mot de antibiotika vi har att behandla med. Fler bakterier blir också resistenta mot mer än ett antibiotikum och behandling av infektioner med dessa typer av bakterier kompliceras av bristen på effektiva läkemedel vilket leder till ökade sjukvårdskostnader, längre vårdtider och en minskad chans att Multi-drug resistant (MDR) infections remain the leading cause of death worldwide. MDR infections caused by Streptococcus pneumoniae (Spn), Streptococcus pyogenes (GAS) and Streptococcus agalactiae (GBS) are considered global threats to human health due to increased spread of antibiotic resistance and limited treatment options. In this thesis, we present the human milk derived HAMLET (Human Alpha-
I mitt forskningsprojekt har jag studerat generna i ’the major histocompatibility complex’ (MHC). Generna i detta komplex kodar för molekyler som uttrycks på cellytan och dessa molekyler är avgörande för immunförsvarets förmåga att upptäcka och bekämpa patogener (sjukdomsalstrande mikroorganismer, som virus, bakterier och parasiter). Det övergripande syftet i min forskning har varit att undersöka Sex differences in immune responses have been observed across a wide range of animal species, with the generaltendency that males have weaker immune responses than females. These differences are at least partly caused by immune-regulating effects of sex hormones, and have been associated with an increased prevalence of autoimmune disorders in females and with a general tendency for males to be par
Objectives: The aim of this study was to explore next of kin’s experiences ofinformation and their information needs after the patient’s discharge for colorectal cancer surgery.Methods: Sixteen next of kin were interviewed twice during the first seven weeksafter the patient’s discharge from hospital. The interviews were analysed through qualitative content analysis.Results: The participants in thiObjectives: The aim of this study was to explore next of kin’s experiences of information and their information needs after the patient’s discharge for colorectal cancer surgery.Methods: Sixteen next of kin were interviewed twice during the first seven weeks after the patient’s discharge from hospital. The interviews were analysed through qualitative content analysis.Results: The participants in t
Freshly ejaculated human semen has the appearance of a loose gel in which the predominant structural protein components are the seminal vesicle-secreted semenogelins (Sg). The primary structure of the 439-residue SgI has previously been obtained by cDNA cloning. This cDNA cross-hybridizes to a larger transcript coding for a second secretory protein, SgII. Here we report the almost complete structu
Universitetslektor Kontaktinformation E-post: tony [dot] ingesson [at] svet [dot] lu [dot] seOrganisation Statsvetenskapliga institutionen Hämtställe: 31 WebbplatsTony Ingessons profil i Lunds universitets forskningsportalStatsvetenskap | UnderrättelseanalysFrämsta forsknings- och undervisningsområdenUnderrättelseanalysKontraspionageBeslutsfattandeVilseledning och manipulation på taktisk nivåPågåe
https://www.svet.lu.se/tony-ingesson - 2026-07-21
Toxin-antitoxin (TA) gene pairs are ubiquitous in microbial chromosomal genomes and plasmids as well as temperate bacteriophages. They act as regulatory switches, with the toxin limiting the growth of bacteria and archaea by compromising diverse essential cellular targets and the antitoxin counteracting the toxic effect. To uncover previously uncharted TA diversity across microbes and bacteriophag
Populärvetenskaplig sammanfattning: För att öka tillgången på mat och att generera arbeten och inkomster är det angeläget för utvecklingsländer att öka produktionen inom jordbruket. En förutsättning för detta är att eliminera produktionshinder genom att dels förbättra jordbruksmetoder, dels identifiera olika områden som är lämpliga för olika typer av jordbruk. Denna Minor Field Study (MFS) är utföThe importance of less developed countries to increase the agricultural production, in order to improve food supplies and generate employment and income, requires the removal of resources constraints by improving agricultural practices and identifying land suitable for different agricultural activities. This Minor Field Study (MFS) is made within the present Sida/SAREC-financed research project “R
Variants in the growth factor receptor-bound protein 10 (GRB10) gene were in a GWAS meta-analysis associated with reduced glucose-stimulated insulin secretion and increased risk of type 2 diabetes (T2D) if inherited from the father, but inexplicably reduced fasting glucose when inherited from the mother. GRB10 is a negative regulator of insulin signaling and imprinted in a parent-of-origin fashion
The human DUSP15 gene encodes an uncharacterized 235-amino acid member of the subfamily of small dual specificity protein phosphatases related to the Vaccinia virus VH1 phosphatase. Similar to VHR-related MKPX (VHX) (DUSP22), the predicted protein has an N-terminal myristoylation recognition sequence, and we show here that both are indeed modified by the attachment of a myristate to Gly-2. In reco
Smoking is a leading cause of preventable death, causing about 5 million premature deaths worldwide each year(1,2). Evidence for genetic influence on smoking behaviour and nicotine dependence (ND)(3-8) has prompted a search for susceptibility genes. Furthermore, assessing the impact of sequence variants on smoking-related diseases is important to public health(9,10). Smoking is the major risk fact
Popular Abstract in Swedish Jorden är ett ytterst komplext och dynamiskt system. Livet har format planeten och utvecklats i takt med förändrade livsvillkor. Ekosystemen kontrolleras i hög grad av klimatet. Snabbt förändrade villkor innebär betydande påfrestningar för åtskilliga arter och ekosystem, inklusive planetens mest dominerande art, människan. Avhandlingens huvudfokus är att undersöka samsThe Earth is a highly complex and dynamic system. Life has shaped the entire planet and evolved in response to living conditions. Ecosystems are heavily affected by climate. Rapidly changing conditions imply considerable stress on several species and ecosystems, as well as to the most dominant species on the planet. The main focus of this thesis is to investigate climate and anthropogenic interac
Popular Abstract in Swedish Hos människan lever en rad mikroorganismer som tillsammans utgör normalfloran. Normalfloran återfinns på alla kroppsytor, det vill säga huden och slemhinnorna i munnen, svalget, magsäcken, tunn- och tjocktarmen, vagina och urinrörsmynningen. Samspelet mellan människokroppen och mikroorganismerna utsätts dagligen för påfrestningar. En sådan naturlig påfrestning är de sjuThis thesis is concerned with a family of bacterial surface proteins expressed by different strains of the anaerobic Gram-positive, commensal and human pathogen Peptostreptococcus magnus. These proteins have been studied with respect to their role in virulence, function, structure, and evolution. Strains isolated from patients with vaginosis have previously been shown to be associated with express
Ett antal studier har visat att buller har negativa hälsoeffekter (Barregård et al. 2005; Rosvall et al. 2009; Nilsson, Eriksson & Palmqvist 2009). Exempel på problem som kan uppstå på grund av buller är sömnsvårigheter, hjärt- och kärlsjukdomar, minskad inlärning och reducerad kognitiv förmåga (Berglund, Lindvall & Schwela 1999). Dessa typer av hälsoproblem leder till lidande för den enskNoise has negative health effects according to a number of studies (Barregård et al. 2005; Rosvall et al. 2009; Nilsson, Eriksson & Palmqvist 2009). Example of problems that can occur from exposure to noise is sleeping disturbances, heart diseases, lessened learning and reduced cognitive performance (Berglund, Lindvall & Schwela 1999). This kind of problems cause suffering on a personal le
