Filtyp
Introduction: Lymphoedema may cause complex problems that can strongly influence patients' health-related quality of life (HRQoL). The main purpose of this study was to investigate the impact of lymphoedema on HRQoL in patients with varying forms of lymphoedema. Methods: The Lymphoedema Quality of Life Inventory (LyQLI), measuring three domains, physical, psychosocial and practical, and the Short
Endothelial progenitor cells (EPCs) contribute to neovasculogenesis and reendothelialization of damaged blood vessels to maintain the endothelium. Dysfunction of EPCs is implicated in the pathogenesis of vascular injury induced by homocysteine (Hcy). We aimed to investigate the role of Cyclin A in Hcy-induced EPCs dysfunction and explore its molecular mechanism. In this study, by treatment of EPCs
The LIM-only protein Lmo2, originally identified as an oncogenic protein in human T cell leukemia, is essential for erythropoiesis. A possible role for Lmo2 in transcription during erythropoiesis has been investigated. Direct interaction of Lmo2 was observed in vitro and in vivo with the zinc finger transcription factor GATA-1, as well as with the basic helix-loop-helix (bHLH) transcription factor
Clustering of testicular cancer cases in families is well known, although the aetiology is not. We present the results of a segregation analysis performed with the algorithm Pointer on familial data on 978 Scandinavian patients with testicular cancer. The segregation analysis favoured the involvement of major gene effects over models incorporating solely polygenic effects in testicular cancer aeti
Skogar täcker ca 31% av jordens landyta och lagrar stora mängder kol i biomassa och i marken. I klimatavtalet från Paris 2015 lyfts skogars roll som sänkor och reservoarer av kol fram och undertecknande länder uppmanas att implementera strategier för hållbart skogsbruk som ytterligare förstärker skogars roll som sänkor av växthusgaser. Ett aktivt skogsbruk påverkar klimat och miljö på många olika Forest ecosystems cover 31% of the terrestrial land area and store large amounts of carbon in biomass and in soils. The 2015 Paris Agreement recognizes the importance of sinks and reservoirs of greenhouse gases (GHGs) in forests and the importance of enhancing them through sustainable forest management policies. Managing forests for climate mitigation purposes is, however, complex since management
Stress-related disorders are a frequent cause for sick leave, with consequences such as great distress and adverse economic effects for the affected person and substantial costs for society. Identifying effective interventions that facilitate return to work is thus important. The aim of this study was to evaluate the effectiveness of the 16-week Redesigning Daily Occupations program as a work reha
Non-compliance with food record submission can induce bias in nutritional epidemiological analysis and make it difficult to draw inference from study findings. We examined the impact of demographic, lifestyle and psychosocial factors on such non-compliance during the first 3 years of participation in a multidisciplinary prospective paediatric study.
Although atherosclerosis starts in early life, evidence on risk factors and atherosclerosis in individuals aged <45 years is scarce. Therefore, we studied the relationship between risk factors, common carotid intima-media thickness (CIMT), and first-time cardiovascular events in adults aged <45 years. Our study population consisted of 3067 adults aged <45 years free from symptomatic cardiovascular
Alzheimer's disease is an increasingly prevalent neurodegenerative disorder whose pathogenesis has been associated with aggregation of the amyloid-β peptide (Aβ42). Recent studies have revealed that once Aβ42 fibrils are generated, their surfaces effectively catalyze the formation of neurotoxic oligomers. Here we show that a molecular chaperone, a human Brichos domain, can specifically inhibit thi
We have analyzed an almost 14,000 year old peat sequence on the island of Isla de los Estados (55 degrees S. 64 degrees W), east of Tierra del Fuego, in the core of the Southern Hemisphere Westerlies. A multitude of methods have been used: high resolution C-14 dating; detailed lithologic descriptions including humification degree; loss on ignition; magnetic susceptibility; bulk density; pollen and
This research project investigates Swedish upper secondary school students’ experiences of engaging with English fiction, both within and outside of the context of their English language classroom. Three focus group interviews were conducted with 18 upper secondary school students from the southern parts of Sweden. Based on the collected data, five themes were identified. The themes were 1) the pe
Hur kan vår vattenanvändning bli mer hållbar? Hur kan vi minska vår förbrukning av dricksvatten? Med stigande temperaturer, klimatförändringar och ökande befolkning blir dessa frågor allt viktigare. Ett förslag är att dra ner på vår dricksvattenkonsumption genom att använda regnvatten. Regnvatten kan användas till att spola i våra toalettstolar, till tvättmaskiner och till bevattning. Men hur kan How can our water consumption become more sustainable? How can our consumption of drinking water decrease? With increasing temperatures, climate changes, and population growth the questions becomes more important. To address this, a suggestion of reducing our drinking water consumption by utilizing rainwater is proposed. Rainwater can be used to flush our toilets, to wash clothes, and for irrigati
We live in a society where online shopping is becoming the most common form of shopping. Companies are investing and growing their online market by offering cheap and quick deliveries, online offers that beat in-store prices and increasing the number of package pick-up locations. We live a faster-paced lifestyle, which makes online shopping more convenient for us. The rapid change in our shopping
The High-Resolution Spectrometers in Hall A at Jefferson Laboratory have been instrumented with state-of-the-art Vertical Drift Chambers designed and constructed by the Nuclear Interactions Group at MITLNS in conjunction with the Physics Division at Jefferson Lab. These chambers rely on a unique, high cell-density design made possible by the absence of field-shaping wires. Each chamber has an inhe
Background: Proteolytic degradation of amyloid β (Aβ) peptides has been intensely studied due to the central role of Aβ in Alzheimer’s disease (AD) pathogenesis. While several enzymes have been shown to degrade Aβ peptides, the main pathway of Aβ degradation in vivo is unknown. Cerebrospinal fluid (CSF) Aβ42 is reduced in AD, reflecting aggregation and deposition in the brain, but low CSF Aβ42 is,
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease associated with a polybacterial dysbiosis devoid of a known pathogen. Here, we report that HS patients mount IgA and IgG responses against skin colonizers, notably Porphyromonas uenonis (Pu), a rare species selectively enriched in severe disease. In these patients, Pu foci are detected in the epidermis, surrounded by IgA deposits
Recently, Peritoneal Surface Oncology Group International (PSOGI) developed a novel comprehensive treatment consisting of cytoreductive surgery (CRS) and perioperative chemotherapy (POC) for the treatment of peritoneal metastases (PM) from gastric cancer with curative intent. This article reviews the results of this treatment and verifies its indication. In this strategy, peritoneal cancer index (
BACKGROUND: Previous research has provided evidence for cognitive dysfunction as a common symptom of systemic lupus erythematosus (SLE). In light of this, the primary goal of this study was to investigate how cognitive impairment in this patient group develops over time. In addition, the present dataset contributes to delineating the specific abilities that are impaired in SLE patients as well as
Current food systems pose one of the greatest health and environmental challenges of the 21st century. Expanded utilization of seaweed for food in Western societies seems like one promising measure in the transition toward sustainable food systems. However, introducing and expanding seaweed to new markets brings certain challenges, such as limited food acceptance and availability. In this pilot coCurrent food systems pose one of the greatest health and environmental challenges of the 21st century. Expanded utilization of seaweed for food in Western societies seems like one promising measure in the transition toward sustainable food systems. However, introducing and expanding seaweed to new markets brings certain challenges, such as limited food acceptance and availability. In this pilot co
