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Background This prospective cohort study aimed to assess whether postoperative radiotherapy could safely be omitted in women aged 65 years and older with low-risk, estrogen receptor-positive T1N0 breast cancer treated with breast-conserving surgery and adjuvant endocrine therapy. Methods Eligible patients were women aged 65 years and older with unifocal, nonlobular, grade 1 or 2, estrogen receptor
Eddy covariance measurement of species that are co-emitted with carbon dioxide (CO2), such as carbon monoxide (CO) and nitrogen oxides NO and NO2 (NOx), provides an opportunity to attribute a net flux to individual source or sink categories. We present eight months of continuous simultaneous measurements of fluxes (F) of CO2, CO, NOx, methane (CH4), and nitrous oxide (N2O) from a tall tower (112 m
Understanding the dynamics of post-fire carbon recovery is critical for managing boreal forests under climate change. This study evaluates the LPJ-GUESS-BLAZE models’ performance in simulating vegetation structure, fire emissions, and post-fire carbon dynamics at the stand scale in a boreal forest in Sweden. Combining current climate and future scenarios (SSP1–2.6, SSP5–8.5), we investigated the i
Dynamisk motorisk talbedömning, DYMTA, är ett test som används för bedömning av talstörning, särskilt vid misstanke om motoriska talsvårigheter. DYMTAs dynamiska testmetod innebär att logopeden ger stöd och ledtrådar under bedömningen för att få en uppfattning om individens maximala förmåga. Yttre tecken ger information som kan härledas till grundorsaker, tex talplaneringssvårigheter.
High variability in stem cell research is a well-known limiting phenomenon, with technical variation across experiments and laboratories often surpassing variation caused by genotypic effects of induced pluripotent stem cell (iPSC) lines. Evaluation of kidney organoid protocols and culture conditions across laboratories remains scarce in the literature. We used the original air-medium interface pr
Sufficiently strong and long-lasting first-order phase transitions can produce primordial black holes (PBHs) that contribute substantially to the dark matter abundance of the Universe, and can produce large-scale primordial magnetic fields. We study these mechanisms in a generic class of conformal U(1)'models that also explain active neutrino oscillation data via the type-I seesaw mechanism. We fi
The European Resuscitation Council (ERC) and the European Society of Intensive Care Medicine (ESICM) have collaborated to produce these post-resuscitation care guidelines for adults, which are based on the International Consensus on Cardiopulmonary Resuscitation Science with Treatment Recommendations (CoSTR) pubished by the International Liaison Committee on Resuscitation (ILCOR). The topics cover
These European Resuscitation Council Guidelines 2025 on epidemiology of resuscitation provides key information about incidence, patients’ characteristics, system organisation and outcomes for both out-of-hospital and in-hospital cardiac arrest in Europe and beyond. Information regarding patients’ post survival experience and causes of cardiac arrest, including genetic factors, are also reported. R
Adaptive network dynamical systems describe the co-evolution of dynamical quantities on the nodes and the dynamics of the network connections themselves. For dense networks of many nodes, the resulting dynamics are typically high-dimensional. Here, we consider adaptive dynamical systems subject to constraints on network adaptation: Asymptotically, the adaptive dynamics of network connections evolv
This paper presents the results from a qualitative study with Swedish researchers in the social sciences and the humanities. The aim of the study was to explore researchers’ perceptions of ethical review (i.e. the pros and cons of the system) and to what extent the system of ethical review could possibly be reformed to better accommodate research in the social sciences and the humanities. To this
Diabetic kidney disease (DKD) is a health burden that lacks specific and early diagnostic biomarkers. For their discovery, we sequenced urinary extracellular vesicle miRNAs in a type 1 diabetes cohort of males with and without DKD. The results were replicated by sequencing or qPCR in two independent cohorts and six published datasets, including type 1 and 2 diabetes, and both sexes. We also valida
Climate warming is expected to influence the prevalence of vector-transmitted parasites. Understanding the extent to which this is ongoing, or has already occurred, requires empirical data from populations monitored over long periods of time, but these studies are sparse. Further, vector-disease research involving human health is often influenced by disease control efforts that supersede natural t
The efficient computation of color-summed QCD amplitudes at high parton multiplicities remains a central challenge for precision collider predictions. Existing approaches using trace, color-flow, or adjoint bases suffer from non-orthogonality, which complicates the color algebra and scales poorly with multiplicity. In this work, we present an off-shell recursive framework for computing all-gluon t
This paper reports on the educational model undertaken in two specialized summer schools in Denmark (2022) and Poland (2023) on daylighting in buildings. As a part of a European educational initiative, these schools aimed to deepen participants' understanding of the impact of daylight on building design. The programme, a collaborative effort between universities, companies, associations, professio
Resilience is a critical issue for water resource systems. Over the past few decades, these systems have been significantly disrupted by natural disasters and human activities, resulting in substantial economic losses. This study develops a resilience evaluation framework based on a comprehensive literature review and applies it to assess the resilience of the Yangtze River Basin (YRB). The result
The proportionality between crime and punishment is made, and the way it is made makes for a certain kind of criminal law. By analyzing how punitive measures are justified in Swedish criminal law and crime policy through appeals to proportionality, the Article demonstrates how proportionality has been made and remade to legitimize an increasingly punitive crime policy, obscuring the reasons for thThe proportionality between crime and punishment is made, and the way it is made makes for a certain kind of criminal law. By analyzing how punitive measures are justified in Swedish criminal law and crime policy through appeals to proportionality, the Article demonstrates how proportionality has been made and remade to legitimize an increasingly punitive crime policy, obscuring the reasons for th
Climate change calls for adaptive strategies to manage land system across governance levels, as differing multi-level policies distinctly shape land system and long-term ecosystem resilience. This study proposes an iterative approach for optimizing land-use pathways that balance competing policy objectives across national, provincial, and local levels without compromising ecosystem integrity in a
BACKGROUND AND OBJECTIVES: The association between dairy intake and dementia risk remains uncertain, especially for dairy products with varying fat contents. The aim of this study was to investigate the association between high-fat and low-fat dairy intake and dementia risk.METHODS: This study used data from a prospective cohort in Sweden, the Malmö Diet and Cancer cohort, which consisted of commu
