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The central component of the complement cascade, C3, is involved in various biological functions, including opsonization of foreign bodies, clearance of waste material, activation of immune cells, and triggering of pathways controlling development. Given its broad role in immune responses, particularly in phagocytosis and the clearance of microbes, a deficiency in complement C3 in humans is often

Background Parathyroid surgery is an appropriate alternative for renal hyperparathyroidism (rHPT) in patients in whom medical therapy fails. European morbidity and outcome data for clearly defined cohorts, potentially reflecting contemporary clinical practice, remain scarce. Method Data were extracted from the EUROCRINE® database on all operations for secondary rHPT between 1 January 2015 and 31 D

A combination of searches for the single production of vectorlike top quarks ((Formula presented)) is presented. These analyses are based on proton-proton collisions at (Formula presented) recorded in 2015-2018 with the ATLAS detector at the Large Hadron Collider, corresponding to an integrated luminosity of (Formula presented). The (Formula presented) decay modes considered in this combination ar

High blood pressure (BP) is a frequent cause for visits to primary healthcare centers (PHCCs) in Sweden. Guidelines on methods for BP measurements for diagnosis of hypertension have recently been updated. We aimed to study adherence to diagnostic guidelines in hypertension management and evaluate whether adherence to guidelines was related to organizational or sociodemographic characteristics. Int

The humoral barrier in transplant biology is the result of preformed donor-specific antibodies (DSAs), directed either against human leukocyte antigens (HLA) or non-HLA antigens such as blood group (ABO) molecules. The term "sensitization" applies to patients carrying these antibodies. Transplantation is widely accepted as a life-saving opportunity for patients with terminal end-organ disease. How

Collective action by small-scale farmers can contribute significantly toward rural development. One important aspect that remains relatively neglected, especially in research set in Africa, is the role of farmer collectives in political processes. We study the local-level dynamics of a farmer-based organization mobilizing for agroecology and food sovereignty in Uganda. Through qualitative, collabo

Transcriptome-wide association studies (TWAS) are powerful tools for identifying gene-level associations by integrating genome-wide association studies and gene expression data. However, most TWAS methods focus on linear associations between genes and traits, ignoring the complex nonlinear relationships that may be present in biological systems. To address this limitation, we propose a novel frame

Virtual reality can be a useful research tool to investigate how people behave in different fire situations. For the results from such experiments to have good validity, i.e., to represent behaviours that can occur in a real environment, the VR environment must be perceived as a good substitute for the real environment. The project focuses on how to achieve such high-quality VR environments. Two d

Eosinophils are increasingly recognized as adaptable immune cells that exhibit diverse phenotypes and effector functions across different tissues and disease states. While they can induce pathology through degranulation and cytotoxic mediator release, eosinophils also fulfill regulatory and tissue repair roles. Advances in single-cell and spatial technologies have begun to reveal how microenvironm

Background Human papillomavirus (HPV) is associated with an increased risk for a variety of squamous cell carcinomas in the general population. The risk for subsequent squamous cell carcinomas in blood or marrow transplantation survivors that are potentially related to HPV (cervical, oropharyngeal, vulvar, vaginal, anal, and penile cancer; HPV-related squamous cell carcinomas) remains unknown. Met

Background: Left-sided pancreatic cancer is associated with worse overall survival (OS) compared with right-sided pancreatic cancer. Although neoadjuvant therapy is currently seen as not effective in patients with resectable pancreatic cancer (RPC), current randomized trials included mostly patients with right-sided RPC. The purpose of this study was to assess the association between neoadjuvant t

This article explores the intricate relation between translation and the Nobel Prize in Literature through the lens of a special case: the 1939 award to Finnish novelist Frans Eemil Sillanpää. The discussions in the Nobel committee, and the decision of the Swedish Academy to select Sillanpää for the prize, were deeply affected by the long and complicated political and cultural history of neighbors

Buildings are responsible for over one-third of global energy use and greenhouse gas emissions, with heating and cooling being major contributors. Phase change materials (PCMs) offer a promising passive solution to improve thermal regulation and reduce heating and cooling loads. This review analyses different experimental and simulation-based studies on the integration of PCMs into building struct

Summary: The relationship between rheumatoid arthritis (RA) and fracture risk was estimated in an international meta-analysis of individual-level data from 29 prospective cohorts. RA was associated with an increased fracture risk in men and women, and these data will be used to update FRAX®. Introduction: RA is a well-documented risk factor for subsequent fracture that is incorporated into the FRA

Context. Wind dynamics play a pivotal role in governing transport processes within planetary atmospheres, influencing atmospheric chemistry, cloud formation, and the overall energy budget. Understanding the strength and patterns of winds is crucial for comprehensive insights into the physics of ultra-hot-Jupiter atmospheres. Current research has proposed different mechanisms that limit wind speeds

Importance: Depressive symptoms are associated with cognitive decline in older individuals. Uncertainty about underlying mechanisms hampers diagnostic and therapeutic efforts. This large-scale study aimed to elucidate the association between depressive symptoms and amyloid pathology. Objective: To examine the association between depressive symptoms and amyloid pathology and its dependency on age,